Abstract: Methods for providing medical conclusions and support therefore comprises measuring of quantities related to concentrations of at least three different biomarkers of control samples, sending, receiving and storing the same in an archive memory. Stored data is retrieved as a response to a sending and receiving of a request for an adapted medical conclusion model and is processed into the certainty deduction model. The adapted medical conclusion model is processed based on the certainty deduction model, and is outputted and received and medical conclusions made from measurements of samples together with the control samples is provided based on the received adapted medical conclusion model. The certainty deduction model comprises a group model, determined for all control samples, and measurement entity performance characteristics, determined for measurements related to the first measurement entity that are performed less than a predetermined time ago.

Abstract: Methods for providing certainty estimation support and certainty estimations, respectively, in medical conclusions comprises measuring of quantities related to concentrations of at least three different biomarkers of control samples, sending, receiving and storing the same in an archive memory. Stored data is retrieved as a response to a sending and receiving of a request for a certainty deduction model and is processed into the certainty deduction model. The certainty deduction model is outputted and received and a certainty estimate for medical conclusions made from measurements of samples together with the control samples is provided based on the received certainty deduction model. The certainty deduction model comprises a group model, determined for all control samples, and measurement entity performance characteristics, determined for measurements related to the first measurement entity that are performed less than a predetermined time ago.

Abstract: Methods for harmonization of test results from a biological sample in a multiplexed biochemical assay, wherein presence and/or concentration of multiple biomarkers are determined at the same time in the same sample, making test results obtained in different laboratories comparable comprise: quantifying a presence or concentration of at least two different biomarkers in a biological sample and in a harmonization standard sample, independently in each sample, by means of a defined multiplexed biochemical assay implemented in a defined type of analytical instrument; receiving the test results from the samples into a computer-based decision engine for harmonization of test results from biological samples; and transforming the test results received from the biological sample, which includes transforming the test results from the harmonization standard sample into generalized units and adjusting the test results of the biological sample into the generalized units, GE.

Abstract: Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method for estimating a risk of relapse of addictive behavior related to exposure to an addictive stimulus, the method including the steps of, at multiple points in time, requesting the individual to measure exposure to the stimulus or answering a questionnaire, measuring the individual's exposure to the stimulus and collecting the individual's questionnaire answers, transmitting a result from the measurement device to a central server unit, storing the result in the central server unit, estimating a risk of relapse based on a combination of the received result and historic results, determining a next point in time for requesting the individual to do at least one of conducting a measurement of the individual's exposure to the stimulus and answering a questionnaire, based on the estimated risk, and if the estimated risk is greater than a predefined level, transmitting a message to a third party informing about the estimated risk.

Abstract: Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.

Abstract: Method for determining characteristic parameters for the interaction between one or more species immobilized to a solid support surface and binding partners to the multispecific species in solution, using at least one solid support with only one target immobilized and at least one solid support with at least two targets immobilized. In the method, the binding curves, both for single-target and multi-target binding are represented as multidimensional fingerprints.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.

Abstract: A method for assessing if an individual or an animal has a selected condition includes: obtaining a biological sample from the individual or animal; detecting in a time-resolved manner the presence of a disease related target through use of a probe (111); calculating a multidimensional fingerprint (141) which represents the recorded binding curves (131); extracting a predefined region (151) or feature of the distribution; and using the region or feature to determine (170) if the individual or animal has the selected condition. The method is particularly advantageous for tissue slices combined with antibody probes, the antibody recognizing receptors known to be over-expressed in cancer. In even more particular, a method for the assessment of HER2 expression level in breast cancer is described.

Abstract: A method of analysis or diagnosis of solid objects is based on real-time detection of how predefined probes interact with structures present on or in the solid object combined with the calculation of how the recorded binding curves of said probes are distributed in terms of interaction properties. The interaction properties are input to a classification algorithm which automatically determines statues of the solid object. The method is particularly advantageous for solid biological objects like tissue slices combined with antibody probes, said antibody recognizing receptors known to be over-expressed in disease states on said tissue slice.

Abstract: A method of screening a plurality of fluid samples for the presence of analytes capable of specifically binding to a ligand immobilized on a sensing surface of a sensor, wherein respective response curves representing the progress of each interaction with time are produced, comprises subjecting a set of resulting response curves to an evaluation procedure comprising determining for each response curve a binder classification based on at least two binding-related features of the response curve, identifying response curves for which the binder classification deviates significantly from that of the remaining response curves as a group, and classifying these deviating response curves as representing sample analytes which are binding partners to the ligand.