Patents by Inventor Karl A. Kelsey

Karl A. Kelsey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230193400
    Abstract: Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival.
    Type: Application
    Filed: September 30, 2022
    Publication date: June 22, 2023
    Inventors: Karl Kelsey, John Wiencke, Devin Koestler, Brock Christensen
  • Publication number: 20220415165
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is described. An exemplary system has a first RFID interrogator and first and second antennas. The first and second antennas direct signals to and receive signals from respective first and second interrogation zones. A first interrogation signal is transmitted to the first antenna. A first acquire window for receiving a signal from a first RFID transponder is opened after the first interrogation signal. A second interrogation signal is transmitted to the second antenna after the first interrogation signal, and a second acquire window for receiving a signal from a second RFID transponder is opened after the second interrogation signal.
    Type: Application
    Filed: August 26, 2022
    Publication date: December 29, 2022
    Applicant: AMTECH SYSTEMS, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 11450203
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is described. An exemplary system has a first RFID interrogator and first and second antennas. The first and second antennas direct signals to and receive signals from respective first and second interrogation zones. A first interrogation signal is transmitted to the first antenna. A first acquire window for receiving a signal from a first RFID transponder is opened after the first interrogation signal. A second interrogation signal is transmitted to the second antenna after the first interrogation signal, and a second acquire window for receiving a signal from a second RFID transponder is opened after the second interrogation signal.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 20, 2022
    Assignee: Amtech Systems, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 10619211
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: April 14, 2020
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, Jr., Carmen Marsit
  • Publication number: 20190284636
    Abstract: Ratio of neutrophils to lymphocytes (NLR) is here associated with immune suppression and decreased survival times in multiple solid tumors. Based on immune cell-specific DMRs and validated cell deconvolution algorithms, the NLR in blood from glioma patients was estimated and glioma patients had elevated mdNLR scores compared to controls. The patient mdNLR scores were increased in patients with grade IV tumors compared to grade II/III. High mdNLR scores were associated with shorter survival. Candidate single (myeloid-associated) gene loci that were highly correlated with the mdNLR were identified. Single myeloid differentiation loci provide a simpler and cheaper alternative to the mdNLR, which requires complex array data. Immunomethylomics are useful and more convenient than conventional cell analysis in profiling glioma risk and survival.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 19, 2019
    Applicants: BROWN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF KANSAS, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Karl Kelsey, John Wiencke, Devin Koestler, Brock Christensen
  • Publication number: 20190180611
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is described. An exemplary system has a first RFID interrogator and first and second antennas. The first and second antennas direct signals to and receive signals from respective first and second interrogation zones. A first interrogation signal is transmitted to the first antenna. A first acquire window for receiving a signal from a first RFID transponder is opened after the first interrogation signal. A second interrogation signal is transmitted to the second antenna after the first interrogation signal, and a second acquire window for receiving a signal from a second RFID transponder is opened after the second interrogation signal.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 10210752
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: February 19, 2019
    Assignee: AMTECH SYSTEMS, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Publication number: 20170186312
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Application
    Filed: March 16, 2017
    Publication date: June 29, 2017
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 9633238
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: April 25, 2017
    Assignee: AMTECH SYSTEMS, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Publication number: 20170067121
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Application
    Filed: September 21, 2016
    Publication date: March 9, 2017
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, JR., Carmen Marsit
  • Publication number: 20150109108
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Application
    Filed: December 3, 2014
    Publication date: April 23, 2015
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 8928462
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 6, 2015
    Assignee: Amtech Systems, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Publication number: 20140178348
    Abstract: Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 26, 2014
    Applicants: The Regents of the University of California, Brown University
    Inventors: Karl Kelsey, Eugene Andres Houseman, John Wiencke, William P. Accomando, JR., Carmen Marsit
  • Publication number: 20120280796
    Abstract: A method for interleaving time slots in a multi-antenna system for communication with RFID tags is disclosed. An example is shown for an eight antenna system. A first four antennas arranged side-by-side are sequentially energized to interrogate RFID transponders. A second set of four antennas arranged side-by-side, the first of which is adjacent to the last of the first set of antennas. A four-antenna sequence is performed for the first four antennas and a second four antenna sequence is performed for the second set of antennas. The first and second four antenna sequences are offset by only a marginal amount, sufficient to ensure that a transponder signal received four antennas away from an active antenna is not acknowledged because the receive window for the non-active antenna is delayed.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Applicant: AMTECH SYSTEMS, LLC
    Inventors: Kelly Gravelle, Michael Melville, Karl Kelsey
  • Patent number: 5726993
    Abstract: A loopback enabled by an instruction and address code pair transmitted with the regular data stream affords a simplified fault location scheme for a T1 repeater span. By selecting unique addresses for each repeater using a predetermined frame sequence and by testing for logic error density, erroneous enablement is avoided.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: March 10, 1998
    Assignee: Siemens Telecom Networks
    Inventors: Karl A. Kelsey, Romuald Bailey
  • Patent number: 5600656
    Abstract: A loopback enabled by an instruction and address code pair transmitted with the regular data stream affords a simplified fault location scheme for a T1 repeater span. By selecting unique addresses for each repeater using a predetermined frame sequence and by testing for logic error density, erroneous enablement is avoided.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: February 4, 1997
    Assignee: Siemens Stromberg-Carlson
    Inventors: Karl A. Kelsey, Romuald Bailey