Abstract: A fiber producing apparatus and method for producing fibers having at least two different dimensions or characteristics. The apparatus cuts fibers of varying length, thickness, and width by varying a cutting stroke length, using a cutting plate having different cutting blades, and applying varying pressure on a material during the cutting process. The fibers of the present invention are moldable and can be used as an implant having a structure that mimics native or natural bones. The ability to mimic natural bone improves cellular infiltration and bone growth.

Abstract: Provided herein are methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.

Abstract: This document provides methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.

Abstract: A therapeutic method is provided to arrest or prevent acute kidney failure by administration of a non-toxic pyruvate salt to a patient in need of such treatment.