Patents by Inventor Karl A. Schellenberg
Karl A. Schellenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240067851Abstract: The present invention relates to a composition, preferably for bonding together metal sheets, comprising: a. 1 part by mole of at least one linear epoxy resin with an average epoxy equivalent weight of 600 to 5,000 g/mole and an epoxy functionality of 2, b. 0.4 to 0.8 parts by mole of at least one non-linear epoxy resin having an average epoxy equivalent weight of 180 to 350 g/mole and an average epoxy functionality of at least 3, c. 0.8 to 1.3 parts by mole of at least one basic hardener comprising at least two free amine-bonded hydrogen atoms, and d. 0.9 to 1.2 parts by mole of at least one crosslinker comprising at least two blocked isocyanate groups.Type: ApplicationFiled: January 14, 2022Publication date: February 29, 2024Inventors: Mario HERKER, Johann SCHELLENBERG, Karl RAMETSTEINER, Christian BREITWIESER, Gerhard TYPPELT
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Patent number: 8796336Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: GrantFiled: July 22, 2011Date of Patent: August 5, 2014Assignee: Eastern Virginia Medical SchoolInventors: Karl A. Schellenberg, Frank A. Lattanzio, James Shaeffer
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Publication number: 20120016030Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: ApplicationFiled: July 22, 2011Publication date: January 19, 2012Applicant: EASTERN VIRGINIA MEDICAL SCHOOLInventors: Karl A. SCHELLENBERG, Frank A. LATTANZIO, James SHAEFFER
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Patent number: 8008347Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: GrantFiled: February 14, 2007Date of Patent: August 30, 2011Assignee: Eastern Virginia Medical SchoolInventors: Karl A. Schellenberg, Frank A. Lattanzio, James Shaeffer
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Publication number: 20090306205Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: ApplicationFiled: February 14, 2007Publication date: December 10, 2009Applicant: Eastern Virginia Medical SchoolInventors: Karl A. Schellenberg, Frank A. Lattanzio, James Shaeffer
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Patent number: 7388028Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: GrantFiled: February 14, 2007Date of Patent: June 17, 2008Assignee: Eastern Virginia Medical SchoolInventors: Karl A. Schellenberg, Frank A. Lattanzio, James Shaefer
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Publication number: 20080039524Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.Type: ApplicationFiled: February 14, 2007Publication date: February 14, 2008Applicant: Eastern Virginia Medical SchoolInventors: Karl Schellenberg, Frank Lattanzio, James Shaeffer
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Patent number: 6020373Abstract: Derivatives useful in the protection of living organisms against damage due to free radical reactions derived from methoxypolyethylene glycols (MPEG), which are modified by chemically attaching chelating groups in an amide or amine linkage to the nonmethyl end of the polymer. Such chelating groups include ethylene-diamine tetraacetic acid (EDTA), diethylene triamine pentaacetic acid (DTPA), and ethylene glycol aminoethyl ether tetraacetic acid (EGTA), and pharmacologically acceptable salts or esters thereof.Type: GrantFiled: April 21, 1997Date of Patent: February 1, 2000Assignee: Eastern Virginia Medical SchoolInventors: Karl A. Schellenberg, James Shaeffer, Frank A. Lattanzio, Jr.
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Patent number: 4676979Abstract: There is disclosed a method of protecting animals including humans against ionizing radiation by injecting the animals with a polymer having the approximate formula H(OCH.sub.2 CH.sub.2).sub.n OH, where n varies between 4 and 13. Particularly, it is found that polyethylene glycol (molecular weight between 200 and 600), polyethyleneglycolmonoethylether (molecular weight between 200 and 600), and polyvinylpyrrolidone (molecular weight up to 10,000) when injected into standard experimental animals, such as mice, protects them from the lethal effect of ionizing radiation.Type: GrantFiled: October 24, 1985Date of Patent: June 30, 1987Assignee: Eastern Virginia Medical Authority/Med. Ctr. Hosp.Inventors: Karl A. Schellenberg, James Shaeffer
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Patent number: 4562158Abstract: A solid phase scintillation counting method is provided wherein a scintillating material is added to an inert carrier and a radioactive substance is caused to contact the carrier either before or after the scintillating material has been applied. The treated carrier is then counted in the solid state in a liquid scintillation counter without the necessity of dissolving the radioactive substance in a liquid solution containing a scintillator. The invention provides a highly efficient and very convenient method for counting low energy radioactive isotopes such as .sup.14 C and .sup.3 H.Type: GrantFiled: July 27, 1981Date of Patent: December 31, 1985Assignee: Eastern Virginia Medical AuthorityInventor: Karl A. Schellenberg