Abstract: Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I Also the production and use of such compounds in pharmaceutical formulations and related methods of treatment.

Abstract: A method for replacing a damaged spinal disc between first and second vertebrae of a spinal column includes connecting a first mounting member with the first vertebra of the spinal column. An artificial disc is moved between the first and second vertebrae and into engagement with the first mounting member to guide the artificial disc into position between the first and second vertebrae. The artificial disc includes a resilient core having a first surface and a second surface, a first retaining member connected to the first surface of the resilient core, and a second retaining member connected to the second surface of the resilient core. The first retaining member has an outer surface engageable with a first vertebra of the spinal column and an inner surface facing the first surface of the resilient core. The second retaining member has an outer surface engageable with the second vertebra of the spinal column and an inner surface facing the second surface of the resilient core.

Abstract: Cyclic substituted aminomethyl compounds of general formula IA and IB, methods for production thereof, intermediates in said production methods, a medicament containing at least one of said cyclic substituted aminomethyl compounds, the use of said cyclic substituted aminomethyl compounds for the production of a medicament, pharmaceutical compositions containing said compounds, and methods for the treatment of pain, incontinence, pruritis, tinnitus aurium and/or diarrhea using said pharmaceutical compositions.

Abstract: Cyclic substituted aminomethyl compounds of general formula IA and IB, methods for production thereof, intermediates in said production methods, a medicament containing at least one of said cyclic substituted aminomethyl compounds, the use of said cyclic substituted aminomethyl compounds for the production of a medicament, pharmaceutical compositions containing said compounds, and methods for the treatment of pain, incontinence, pruritis, tinnitus aurium and/or diarrhea using said pharmaceutical compositions.

Abstract: A weight training apparatus that allows the user to safely perform free-bar type bench press exercises, both in the standard fashion and in the more effective eccentric contraction fashion is described. The weight bar is attached to a cable system that incorporates a safety stop to prevent the weight bar from crushing the chest of the user in case of accident and especially features a guided sled proximal the user's feet and connected to the weight bar by the same cable system and whereby the user may, at his option at any time during the exercise, partially support or lift the weight bar by engaging the guided sled with his feet and pushing it using his leg muscles.