Patents by Inventor Karl Andreas Karlsson

Karl Andreas Karlsson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
    Patent number: 9133168
    Abstract: The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: September 15, 2015
    Assignee: SANOFI
    Inventors: Maurice Brollo, Jean-Christophe Carry, Victor Certal, Eric Didier, Gilles Doerflinger, Youssef El Ahmad, Frank Halley, Karl Andreas Karlsson
  • (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
    Patent number: 8993565
    Abstract: The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: March 31, 2015
    Assignee: Sanofi
    Inventors: Jean-Christophe Carry, Victor Certal, Frank Halley, Karl Andreas Karlsson, Laurent Schio, Fabienne Thompson
  • NOVEL (6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL)AMIDE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS
    Publication number: 20140303156
    Abstract: The invention relates to the novel materials of formula (I), where: R1 is an optionally substituted aryl or heteroaryl; R is an H or, when formed with R1, a 5- or 6-member ring fused with an aryl or heretoaryl group optionally containing one or more of O, S, N, NH, and Nalk, being optionally substituted; R2 and R3 are, independently, an H, Hal, or alkyl optionally substituted by one or more Hal; R4 is H; and R5 is an H or alkyl optionally substituted by one or more halogen atoms. Said materials being in any isomeric form and the salts thereof, and are intended for drugs, particularly AKT(PKB) phosphorylation inhibitors.
    Type: Application
    Filed: June 23, 2014
    Publication date: October 9, 2014
    Inventors: Jean-Christophe CARRY, Victor CERTAL, Frank HALLEY, Karl Andreas KARLSSON, Laurent SCHIO, Fabienne THOMPSON
  • 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
    Patent number: 8846670
    Abstract: The invention relates to compounds of the formula: or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: September 30, 2014
    Assignee: Sanofi
    Inventors: Eric Bacque, Maurice Brollo, Annie Clauss, Youssef El Ahmad, Bruno Filoche-Romme, Frank Halley, Karl Andreas Karlsson, Gilbert Marciniak, Baptiste Ronan, Laurent Schio, Bertrand Vivet, Fabrice Viviani, Andre Zimmermann
  • 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
    Patent number: 8828997
    Abstract: The invention relates to a product of formula (I) where R1, R2, R3, and R4 are as defined herein, the therapeutic use of the product, a process to make the product, and a pharmaceutical composition comprising the product.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: September 9, 2014
    Assignee: Sanofi
    Inventors: Maurice Brollo, Annie Clauss, Youssef El Ahmad, Bruno Filoche-Romme, Frank Halley, Karl Andreas Karlsson, Gilbert Marciniak, Baptiste Ronan, Laurent Schio, Bertrand Vivet, Fabrice Viviani, Andre Zimmermann
  • (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
    Patent number: 8791255
    Abstract: The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: July 29, 2014
    Assignee: Sanofi
    Inventors: Jean-Christophe Carry, Victor Certal, Frank Halley, Karl Andreas Karlsson, Laurent Schio, Fabienne Thompson
  • NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS
    Publication number: 20130274253
    Abstract: The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 17, 2013
    Applicant: SANOFI
    Inventors: Maurice Brollo, Jean-Christophe Carry, Victor Certal, Eric Didier, Gilles Doerflinger, Youssef EL Ahmad, Bruno Filoche-Romme, Frank Halley, Karl Andreas Karlsson, Laurent Schio, Fabienne Thompson
  • 1H-pyrimidin-2-one derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of AKT (PKB) phosphorylation
    Patent number: 8507483
    Abstract: The invention relates to the novel products of formula (I): in which Z represents —O—, —NH or Nalk; n represents 0 to 4; R1 represents Hal, hydroxyl, alkyl or alkoxy; the alkyl and alkoxy radicals being optionally substituted; R2 and R3 represent H, Hal or alkyl optionally substituted with one or more halogen atoms; R4 represents H; these products being in all the isomer forms and the salts, as medicaments, in particular as inhibitors of AKT(PKB) phosphorylation.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 13, 2013
    Assignee: Sanofi
    Inventors: Victor Certal, Bruno Filoche-Rommé, Frank Halley, Karl Andreas Karlsson, Fabienne Thompson
  • NOVEL (6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL)AMIDE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS
    Publication number: 20120270867
    Abstract: The invention relates to the novel materials of formula (I), where: R1 is an optionally substituted aryl or heteroaryl; R is an H or, when formed with R1, a 5- or 6-member ring fused with an aryl or heretoaryl group optionally containing one or more of O, S, N, NH, and Nalk, being optionally substituted; R2 and R3 are, independently, an H, Hal, or alkyl optionally substituted by one or more Hal; R4 is H; and R5 is an H or alkyl optionally substituted by one or more halogen atoms. Said materials being in any isomeric form and the salts thereof, and are intended for drugs, particularly AKT(PKB) phosphorylation inhibitors.
    Type: Application
    Filed: December 27, 2011
    Publication date: October 25, 2012
    Applicant: SANOFI
    Inventors: Jean-Christophe CARRY, Victor CERTAL, Frank HALLEY, Karl Andreas KARLSSON, Laurent SCHIO, Fabienne THOMPSON
  • NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO(1,2-A)PYRIMIDIN-6-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF
    Publication number: 20120208810
    Abstract: The invention relates to the novel materials of formula (I), where: R1 is an optionally substituted L-aryl or L-heteroaryl, such that L is a single bond, alkyl, CO, or CO-alk, or L-X, with L? being an alkyl and X being O or S; R2 is H or alkyl; R3 is an alkyl optionally substituted by Hal; and R4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.
    Type: Application
    Filed: July 1, 2010
    Publication date: August 16, 2012
    Applicant: SANOFI
    Inventors: Eric Bacque, Maurice Brollo, Annie Clauss, Youssef El Ahmad, Bruno Filoche-Romme, Frank Halley, Karl Andreas Karlsson, Gilbert Marciniak, Baptiste Ronan, Laurent Schio, Bertrand Vivet, Fabrice Viviani, Andre Zimmermann
  • NOVEL 1H-PYRIMIDIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS INHIBITORS OF AKT (PKB) PHOSPHORYLATION
    Publication number: 20120172360
    Abstract: The invention relates to the novel products of formula (I): in which Z represents —O—, —NH or Nalk; n represents 0 to 4; R1 represents Hal, hydroxyl, alkyl or alkoxy; the alkyl and alkoxy radicals being optionally substituted; R2 and R3 represent H, Hal or alkyl optionally substituted with one or more halogen atoms; R4 represents H; these products being in all the isomer forms and the salts, as medicaments, in particular as inhibitors of AKT(PKB) phosphorylation.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 5, 2012
    Applicant: SANOFI
    Inventors: Victor CERTAL, Bruno FILOCHE-ROMME, Frank HALLEY, Karl Andreas KARLSSON, Fabienne THOMPSON
  • NOVEL 2,3-DIHYDRO-1H-IMIDAZO(1,2-A)PYRIMIDIN-5-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF
    Publication number: 20120142679
    Abstract: The invention relates to the novel materials of formula (I), where R1 is an optionally substituted L-aryl or -heteroaryl, such that L is: an alkyl or CO, or LX, with Lbeing an alkyl and X being O or S; R2 is H or an alkyl; R3 is an alkyl optionally substituted by Hal; and R4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.
    Type: Application
    Filed: July 1, 2010
    Publication date: June 7, 2012
    Applicant: SANOFI
    Inventors: Maurice Brolio, Annie Clauss, Youssef El Ahmad, Bruno Filoche-Romme, Frank Halley, Karl Andreas Karlsson, Gilbert Marciniak, Baptiste Ronan, Laurent Schio, Bertrand Vivet, Fabrice Viviani, Andre Zimmermann