Abstract: Sealing profile for motor vehicles and method of manufacture thereof. The sealing profile (1) comprises a retaining part (2) of U-shaped cross-section and sealing parts (3, 4) formed thereon. On an inner surface (13) of a bridge (5) of the retaining part (2) there is positioned an elastomeric mixture which can be vulcanized to a permanently elastic, permanently adhesive and open-cell foamed sealing strand (14). The sealing strand (14) is deformed during the fitting of the sealing profile (1) by a bodywork flange of a motor vehicle. In this way the retaining part (2) provides a reliable seal relative to the flange.