Patents by Inventor Karl Brenner

Karl Brenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10822388
    Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: November 3, 2020
    Assignee: University Health Network
    Inventors: Michael W. Tusche, Tak W. Mak, Pamela S. Ohashi, Philipp Lang, Karl Lang, Dirk Brenner, Gloria Lin
  • Patent number: 5319111
    Abstract: A process for the preparation of tetrahydrofuran or tetrahydrofuran and .gamma.-butyrolactone from the product of the hydrogenation of maleic acid, succinic acid, maleic anhydride, succinic anhydride and/or fumaric acid, by treating the crude hydrogenation product, without prior work-up, at from 100.degree. to 300.degree. C. with a protic acid, and isolating pure tetrahydrofuran and .gamma.-butyrolactone from the resultant reaction mixture by distillation.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: June 7, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Zimmermann, Karl Brenner, Hans-Juergen Scheiper, Wolfgang Sauer, Horst Hartmann
  • Patent number: 5268913
    Abstract: The invention is directed to a frequency-doubling solid state laser having pump light sources at opposite ends thereof. A folding and out-coupling mirror is antireflection coated on both sides with respect to the wavelength of the light generated by the pump light sources. The pump light sources include a total of four laser diodes with each laser diode generating 3 Watts of light power. An output power at 532 nm is obtained using a Nd:YAG laser rod and a frequency-doubling crystal made of potassium titanyl phosphate. The folding angle defined by the folding and out-coupling mirror is in the range of 10.degree. to 60.degree. and is typically 50.degree..
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: December 7, 1993
    Assignee: Carl-Zeiss-Stiftung
    Inventors: Harald Sakowski, Karl Brenner, Peter Greve
  • Patent number: 5149884
    Abstract: In a tube bundle reactor for carrying out catalytic organic reactions in the gas phase, comprising reaction tubes (A) arranged between tubesheets (B), the reaction tubes have an inside diameter ranging from 0.5 to 3 cm, the ratio of reaction tube length to inside diameter ranges from 2 to 10, and the reaction tubes (A) are surrounded by a fluid heat transport medium flowing in the crosswise direction; said tube bundle reactor is useful in particular in exothermic organic reactions.
    Type: Grant
    Filed: April 1, 1991
    Date of Patent: September 22, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl Brenner, Wilhelm Ruppel, Otto Woerz, Klaus Halbritter, Hans-Juergen Scheiper, Werner Aquila, Hartwig Fuchs
  • Patent number: 5120880
    Abstract: Muscone of the formula I ##STR1## is prepared by a process in which an open-chain 2,15-diketone of the general formula IICH.sub.3 --CO--X--CO--CH.sub.3 (II)whereX is one of the radicals--(--CH.sub.2 --).sub.12 -- (a)--CH.dbd.CH--(--CH.sub.2 --).sub.8 --CH.dbd.CH-- (b)--CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.6 --CH.dbd.CH--CH.sub.2 --(c)--CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.4 --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- (d)or--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (e)is brought into contact, at from 300.degree. to 400.degree. C. in the presence of from 5 to 15% by weight, based on the amount of catalyst, of water, in the gas phase, with a fixed-bed catalyst containing TiO.sub.2, CeO.sub.2 or ThO.sub.2 as the catalytically active compound and the unsaturated cyclic ketone formed by intramolecular aldol condensation is subjected to catalytic hydrogenation.
    Type: Grant
    Filed: September 10, 1991
    Date of Patent: June 9, 1992
    Assignee: BASF Atkiengesellschaft
    Inventors: Michael Huellmann, Thomas Kuekenhoehner, Karl Brenner, Rainer Becker, Matthias Irgang, Charles Schommer
  • Patent number: 5081311
    Abstract: Muscone of the formula I ##STR1## is prepared by a process in which an open-chain 2,15-diketone of the general formula IICH.sub.3 --CO--X--CO--CH.sub.3 (II)where X is one of the radicals--(--CH.sub.2 --).sub.12 -- (a)--CH.dbd.CH--(--CH.sub.2 --).sub.8 --CH.dbd.CH-- (b)--CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.6 --CH.dbd.CH--CH.sub.2 --(c)--CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.4 --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- (d) or--CH.sub.2 --CH.sub.2 CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (e)is brought into contact, at from 300.degree. to 400.degree. C. in the presence of from 5 to 15% by weight, based on the amount of catalyst, of water, in the gas phase, with a fixed-bed catalyst containing TiO.sub.2, CeO.sub.2 or the ThO.sub.2 as the catalytically active compound and the unsaturated cyclic ketone formed by intramolecular aldol condensation is subjected to catalytic hydrogenation.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: January 14, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Huellmann, Thomas Kuekenhoehner, Karl Brenner, Rainer Becker, Matthias Irgang, Charles Schommer
  • Patent number: 5031184
    Abstract: The invention is directed to a cooling arrangement for a semiconductor pump source which develops heat during operation. The cooling arrrangement includes a heat sink defining a seat for accommodating the pump source thereon and a cooling channel is formed in the heat sink for conducting a coolant therethrough to remove a major portion of the heat. A Peltier device is connected to the heat sink for finely controlling the temperature of the heat sink so as to permit the semiconductor pump source to emit radiation having a predetermined optional wavelength.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: July 9, 1991
    Assignee: Carl-Zeiss-Stiftung
    Inventors: Peter Greve, Martin Blumentritt, Harald Sakowski, Karl Brenner
  • Patent number: 4940805
    Abstract: Process for the preparation of 1,4-butanediol or tetrahydrofuran or both by the catalytic hydrogenation of maleic anhydride, succinic anhydride, maleic acid, succinic acid, fumaric acid, or the alkyl esters of these acids at temperatures of from 100.degree. C. to 350.degree. C. and pressures of from 50 bar to 350 bar over a catalyst containing cobalt as the active metal and one or both of the elements copper and phosphorus, if necessary in the presence of an aliphatic alcohol.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: July 10, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Fischer, Hans-Juergen Gosch, Wolfgang Harder, Klaus-Dieter Malsch, Manfred Eggersdorfer, Lothar Franz, Horst Zimmermann, Karl Brenner, Klaus Halbritter, Wolfgang Sauer, Hans-Juergen Scheiper
  • Patent number: 4816606
    Abstract: Aldehydes and ketones of the general formula I ##STR1## where R.sup.1 is hydrogen or an organic radical of 1 to n carbon atoms and R.sup.2 is a non-aromatic organic radical of 1 to m carbon atoms, (m+n) ranging from 2 to 24 and R.sup.1 and R.sup.2 being combinable to form a 4- to 12-membered ring, are prepared in a continuous manner by oxidizing an alcohol of the general formula II ##STR2## with oxygen or an oxygen-containing gas at elevated temperatures in the gas phase in the presence of a catalyst, by effecting the oxidation by means of a supported catalyst composed of an inert carrier having a smooth surface and from 0.1 to 20% by weight, based on the amount of carrier, of an active layer of copper, silver and/or gold in a tubular reactor or tube bundle reactor where the internal diameter D of the tube or tubes ranges from 10 to 50 mm and the largest diameter d of the coated supported catalysts is subject to the relationship d=from 0.1 to 0.2 D.
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: March 28, 1989
    Assignee: Basf Aktiengesellschaft
    Inventors: Karl Brenner, Manfred Eggersdorfer, Wilhelm Ruppel, Harald Schultheiss, Hans-Ulrich Scholz
  • Patent number: 4440960
    Abstract: A process for the continuous preparation of 3-alkyl-buten-1-als by oxidative dehydrogenation of 3-alkyl-buten-1-ols at from 320.degree. to 650.degree. C. with oxygen over a catalyst containing copper and/or silver, wherein, within one second after contact with the catalyst, the vaporous reaction mixture, which is at from 320.degree. to 650.degree. C., is brought into contact with a liquid comprising water and/or the condensed reaction mixture at from -20.degree. to 50.degree. C., and the 3-alkyl-buten-1-als are separated off from the resulting condensate.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: April 3, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Sauer, Werner Aquila, Wolfgang Hoffmann, Karl Brenner, Klaus Halbritter