Patents by Inventor Karl-Christian Engel

Karl-Christian Engel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PSEUDOFAB-BASED MULTISPECIFIC BINDING PROTEINS
    Publication number: 20230391888
    Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Application
    Filed: March 17, 2023
    Publication date: December 7, 2023
    Inventors: Christian Beil, Karl-Christian Engel, Gerhard Hessler, Soraya Hoelper, Christian Lange, Thomas Langer, Cendrine Lemoine, Wulf-Dirk Leuschner, Sevim Ozgur Bruderle, Ercole Rao, Nadja Spindler, Sandra Weil
  • PseudoFab-based multispecific binding proteins
    Patent number: 11739160
    Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 29, 2023
    Assignee: SANOFI
    Inventors: Christian Beil, Karl-Christian Engel, Gerhard Hessler, Soraya Hoelper, Christian Lange, Thomas Langer, Cendrine Lemoine, Wulf-Dirk Leuschner, Sevim Ozgur Bruderle, Ercole Rao, Nadja Spindler, Sandra Weil
  • PSEUDOFAB-BASED MULTISPECIFIC BINDING PROTEINS
    Publication number: 20200255540
    Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Application
    Filed: December 23, 2019
    Publication date: August 13, 2020
    Inventors: Christian Beil, Karl-Christian Engel, Gerhard Hessler, Soraya Hoelper, Christian Lange, Thomas Langer, Cendrine Lemoine, Wulf-Dirk Leuschner, Sevim Oezguer Bruederle, Ercole Rao, Nadja Spindler, Sandra Weil
  • Phenothiazine derivative having a double bond, method for the production thereof, and use thereof as a pharmaceutical
    Patent number: 8207146
    Abstract: The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: June 26, 2012
    Assignee: Sanofi-Aventis
    Inventors: Stefanie Keil, Elisabeth Defossa, Dieter Schmoll, Axel Dietrich, Johanna Kuhlmann-Gottke, Karl-Christian Engel
  • PHENOTHIAZINE DERIVATIVE HAVING A DOUBLE BOND, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A PHARMACEUTICAL
    Publication number: 20100261643
    Abstract: The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
    Type: Application
    Filed: March 16, 2010
    Publication date: October 14, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Stefanie KEIL, Elisabeth DEFOSSA, Dieter SCHMOLL, Axel DIETRICH, Johanna KUHLMANN-GOTTKE, Karl-Christian ENGEL
  • Phenothiazin derivatives, method for the production thereof and use thereof as pharmaceuticals
    Patent number: 7732440
    Abstract: The invention relates to compounds of the formula I, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: June 8, 2010
    Assignee: Sanofi-Aventis
    Inventors: Stefanie Keil, Elisabeth Defossa, Karl Schoenafinger, Dieter Schmoll, Axel Deitrich, Johanna Kuhlmann-Gottke, Karl-Christian Engel
  • PHENOTHIAZIN DERIVATES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS PHARMACEUTICALS
    Publication number: 20090325942
    Abstract: The invention relates to compounds of the formula 1, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.
    Type: Application
    Filed: July 22, 2009
    Publication date: December 31, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Stefanie KEIL, Elisabeth DEFOSSA, Karl SCHOENAFINGER, Dieter SCHMOLL, Axel DIETRICH, Johanna KUHLMANN-GOTTKE, Karl-Christian ENGEL