Patents by Inventor Karl D. Hargrave

Karl D. Hargrave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6458959
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: October 1, 2002
    Assignees: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim (Canada) Ltd.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6348477
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: February 19, 2002
    Assignees: Boehringer Ingelheim(Canada) Ltd., Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Antiherpes virus compounds and methods for their preparation and use
    Patent number: 6288091
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: September 11, 2001
    Assignees: Boehringer Ingelheim Ltd., Boehringer Ingelheim Pharm. Inc.
    Inventors: J. James Crute, Anne-Marie Faucher, Christine Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • 4-substituted beta-carbolines and analogs thereof
    Patent number: 6093723
    Abstract: This invention relates to 4-substituted .beta.-carbolines and .beta.-carboline analogs that inhibit Ca.sup.+2 influx and interleukin-2 (IL-2) production. The 4-substituted .beta.-carbolines and .beta.-carboline analogs of this invention are represented by formula (I): ##STR1## wherein Q, n, R, R', R" and R.sub.1 -R.sub.4 are as defined herein. This invention also relates to methods for producing .beta.-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: July 25, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Clara K Miao, Ian F. Potocki, Roger J. Snow, Karl D. Hargrave, Thomas P. Parks
  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6057451
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: May 2, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • 5,6-Heteroaryl-dipyrido(2,3-B:3', 2'-F) azepines and their use in the prevention or treatment of HIV infection
    Patent number: 5919779
    Abstract: "There are disclosed compounds of the formula I, II or III ##STR1## wherein A and D are carbon or nitrogen and B is oxygen, sulfur or nitrogen which are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: July 6, 1999
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: John R. Proudfoot, Karl D. Hargrave, Suresh Kapadia
  • 5,11-dihydro-6H-dipyrido?3,2-b:2',3'-e!azepine-6-ones and their use in the prevention of treatment of HIV infection
    Patent number: 5908841
    Abstract: There are disclosed compounds of the formula 1 ##STR1## wherein X is an oxygen atom or nothing and R1, R2 and R3 are as defined in the specification, useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: June 1, 1999
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: John R. Proudfoot, Karl D. Hargrave
  • 2-aryl-5,11-dihydro-6H-dipyrido?3,2-B:2',3'-E!?1, 4!diazepines and their use in the treatment of HIV infection
    Patent number: 5747488
    Abstract: Disclosed are novel 2-aryl-5,11-dihydro-6H-dipyrido?3,2-b:2',3'-e!?1,4!diazepines. These are useful in the of HIV infection. Exemplary compounds are:8-Ethyl-1-methyl-10-(4-pyrazolyl)imidazo?2',3':6,5!dipyrido?3,2-b:2',3'-e!? 1,4!diazepine;8-c-Propyl-1-methyl-10-(4-pyrazolyl)imidazo?2',3':6,5!dipyrido?3,2-b:2',3'- e!?1,4!diazepine;8-Ethyl-12-methyl-10-(4-pyrazolyl)imidazo?2',3':6,5!dipyrido?3,2-b:2',3'-e! ?1,4!diazepine; and,8-c-Propyl-12-methyl-10-(4-pyrazolyl)imidazo?2',3':6,5!dipyrido?3,2-b:2',3 '-e!?1,4!diazepine.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: May 5, 1998
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot
  • Method for the preparation of 3-amino-2-chloro-4-methylpyridines
    Patent number: 5668287
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: September 16, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • 5,11-dihyro-6H-dipyrido[3,2-B:2',3'-e][1,3]diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5620974
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 15, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5602113
    Abstract: Disclosed are novel pyrido[2,3,-b][1,5]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: February 11, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Pyridobenzo-and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5593979
    Abstract: Disclosed are novel pyrido[2,3-b][1,4]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
    Patent number: 5571912
    Abstract: This invention relates to a novel method for preparing certain dipyrido-diazepines.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Dibenz[b,f][1,4]oxazepin(and thiazepin)-11(10H)-ones and-thiones and their use in the prevention or treatment of HIV infection
    Patent number: 5571806
    Abstract: Disclosed is the use of dibenz[b,f][1,4]oxazepin (or thiazepin)-11(10H)-ones and -thiones in the prevention and treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Kurt Schromm
  • The treatment of HIV-1 infection using certain pyridodiazepines
    Patent number: 5571809
    Abstract: Disclosed are novel pyridodiazepines. These compounds, as well certain known 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-ones are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Dipyrido[3,2-B:2 ',3'-E][1,4]Diaqzepines and their use in the treatment of HIV infection
    Patent number: 5550117
    Abstract: Disclosed are novel dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the treatment of HIV-1 infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: August 27, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Pyrido[2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and thiones and their use on the treatment of HIV infection
    Patent number: 5550122
    Abstract: Disclosed are pyrido[2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones. These are useful in the prevention or treatment of AIDS.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: August 27, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased
  • Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones and their use in the prevention or treatment of HIV-1 infection
    Patent number: 5547951
    Abstract: Compounds of the class of pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones, having the following general structural formula ##STR1## wherein either X or Z is sulfur and the other substituent is oxygen or both X and Z are sulfur, which are inhibitors of HIV-1 reverse transcriptase and useful in the treatment of HIV-1 infection. An exemplary compound is 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: August 20, 1996
    Assignee: Boehringer Ingelheim Pharamceuticals, Inc.
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased
  • Alkylarylketo acids
    Patent number: 5504244
    Abstract: Disclosed are novel alkylarylketocarboxylic acids and 5-substituted tetrazoles represented by the formula ##STR1## wherein Z is aryl or an alkyl of the structure ##STR2## W is a carboxyl moiety or a tetrazole moiety bound to Z at the 5-position of the tetrazole;R.sub.1 is C.sub.4 -C.sub.12 alkyl where Z is aryl and X is oxygen or is C.sub.5 -C.sub.12 alkyl where Z is alkyl and where Z is aryl and X is a bond;R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, halogen, trihalomethyl, nitro, cyano or C.sub.1 -C.sub.4 acyl;R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl or R.sub.4 and R.sub.6 or R.sub.5 and R.sub.7 can combine to form a carbocyclic ring;X is oxygen, or a bond at the ortho or para position;m is 0, 1 or 2; andn is 0 or 1, and nontoxic, pharmaceutically acceptable addition salts and carboxylic acid esters thereof.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: April 2, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John P. Devlin
  • 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5366972
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: November 22, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein