Patents by Inventor Karl Deisseroth

Karl Deisseroth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS
    Publication number: 20160331995
    Abstract: Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.
    Type: Application
    Filed: August 4, 2016
    Publication date: November 17, 2016
    Inventors: Karl Deisseroth, Feng Zhang, Edward Boyden
  • STABILIZED STEP FUNCTION OPSIN PROTEINS AND METHODS OF USING THE SAME
    Publication number: 20160316730
    Abstract: Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno
  • UPCONVERSION OF LIGHT FOR USE IN OPTOGENETIC METHODS
    Publication number: 20160317658
    Abstract: Provided herein are compositions comprising lanthanide-doped nanoparticles which upconvert electromagnetic radiation from infrared or near infrared wavelengths into the visible light spectrum. Also provided herein are methods activating light-responsive opsin proteins expressed on plasma membranes of neurons and selectively altering the membrane polarization state of the neurons using the light delivered by the lanthanide-doped nanoparticles.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Inventors: Karl Deisseroth, Polina Anikeeva
  • CONTROL AND CHARACTERIZATION OF PSYCHOTIC STATES
    Publication number: 20160316732
    Abstract: Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Inventors: Karl Deisseroth, Vikaas Sohal, Lisa Gunaydin
  • Optical Tissue Interface Method and Apparatus For Stimulating Cells
    Publication number: 20160303396
    Abstract: In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
    Type: Application
    Filed: March 20, 2013
    Publication date: October 20, 2016
    Inventors: Karl Deisseroth, Alexander Aravanis, Feng Zhang, M. Bret Schneider, Jaimie M. Henderson
  • OPTICALLY-CONTROLLED CNS DYSFUNCTION
    Publication number: 20160303192
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Application
    Filed: June 27, 2016
    Publication date: October 20, 2016
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • Functional Targeted Brain Endoskeletonization
    Publication number: 20160290899
    Abstract: Compositions and methods are provided for TEMPEST (Target-Element Modification by Physical and Enduring Structural Transmutation), a method for creating durable structures in vivo in a cell-type and/or circuit specific manner via the use of insoluble polymers. TEMPEST provides a way to functionally remove cells while preserving their “shadow” for easy post-experiment detection and classification. The method of the invention are of particular interest for modifying neurons, which may be central nervous system or peripheral nervous system cells, however the approach may be applied to other cellular systems as well, either in culture system models or in animals.
    Type: Application
    Filed: April 4, 2016
    Publication date: October 6, 2016
    Inventors: Karl A. Deisseroth, Viviana Gradinaru
  • LIGHT-SENSITIVE ION-PASSING MOLECULES
    Publication number: 20160287895
    Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
    Type: Application
    Filed: May 12, 2016
    Publication date: October 6, 2016
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • Optically-based stimulation of target cells and modifications thereto
    Patent number: 9458208
    Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: October 4, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lisa Gunaydin, Peter Hegemann, Andre Berndt
  • OPTICAL TISSUE INTERFACE METHOD AND APPARATUS FOR STIMULATING CELLS
    Publication number: 20160279267
    Abstract: In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
    Type: Application
    Filed: May 16, 2016
    Publication date: September 29, 2016
    Inventors: Karl Deisseroth, Alexander Aravanis, Feng Zhang, M. Bret Schneider, Jaimie M. Henderson
  • Cell line, system and method for optical control of secondary messengers
    Patent number: 9453215
    Abstract: A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, Beta2)}. The light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: September 27, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Raag D. Airan
  • OPTOGENETIC MAGNETIC RESONANCE IMAGING
    Publication number: 20160270723
    Abstract: Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
    Type: Application
    Filed: January 27, 2016
    Publication date: September 22, 2016
    Inventors: Karl Deisseroth, Jin Hyung Lee
  • CELL LINE, SYSTEM AND METHOD FOR OPTICAL-BASED SCREENING OF ION-CHANNEL MODULATORS
    Publication number: 20160258929
    Abstract: A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
    Type: Application
    Filed: May 12, 2016
    Publication date: September 8, 2016
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru, M. Bret Schneider
  • LIGHT-ACTIVATED CATION CHANNEL AND USES THEREOF
    Publication number: 20160252524
    Abstract: The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 1, 2016
    Inventors: Karl Deisseroth, Edward S. Boyden
  • Optically controlled CNS dysfunction
    Patent number: 9421258
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: August 23, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
    Publication number: 20160237126
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 18, 2016
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • OPSIN POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20160222073
    Abstract: The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are useful in therapeutic and screening applications, which are also provided.
    Type: Application
    Filed: April 13, 2016
    Publication date: August 4, 2016
    Inventors: Karl Deisseroth, Feng Zhang
  • Methods for treating parkinson's disease by optically stimulating target cells
    Patent number: 9394347
    Abstract: Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: July 19, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • COMPOSITIONS AND METHODS FOR CONTROLLING PAIN
    Publication number: 20160199663
    Abstract: The present disclosure provides compositions and methods for controlling pain. The present disclosure provides methods for identifying agents that control pain.
    Type: Application
    Filed: August 13, 2014
    Publication date: July 14, 2016
    Inventors: Shrivats Mohan Iyer, Scott L. Delp, Kathryn L. Montgomery, Karl A. Deisseroth, Christopher Towne
  • SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS
    Publication number: 20160194624
    Abstract: Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.
    Type: Application
    Filed: October 19, 2015
    Publication date: July 7, 2016
    Inventors: Karl Deisseroth, Feng Zhang, Edward Boyden