Patents by Inventor Karl Dietmann
Karl Dietmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4608383Abstract: The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamide, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R.sub.5 and R.sub.6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.Type: GrantFiled: October 3, 1983Date of Patent: August 26, 1986Assignee: Boehringer Mannheim GmbHInventors: Fritz Wiedemann, deceased, Wolfgang Kampe, Karl Dietmann, deceased, Gisbert Sponer
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Patent number: 4503067Abstract: Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--;X is a valency bond, --CH.sub.2 --, oxygen or sulfur;Ar is mono- or bicyclic aryl or pyridyl;R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl;R.sub.5 and R.sub.6 together can represent methylenedioxy;and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.Type: GrantFiled: April 4, 1983Date of Patent: March 5, 1985Assignee: Boehringer Mannheim GmbHInventors: Fritz Wiedemann, Wolfgang Kampe, Max Thiel, Gisbert Sponer, Egon Roesch, Karl Dietmann
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Patent number: 4468520Abstract: The present invention provides aminopropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkanoyl or an aroyl radical, R.sub.2 is a lower alkyl radical or a radical of the general formula: ##STR2## wherein X is a valency bond, a methylene group or an oxygen or sulphur atom, Ar is a monocyclic, carbo- or heterocyclic aryl radical, R.sub.6 and R.sub.7, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.8 and R.sub.9, which can be the same or different, are hydrogen or halogen atoms, hydroxyl groups, lower alkanoyl radicals, alkenyl radicals, alkynyl radicals, alkyl radicals, lower alkoxy radicals, aralkoxy radicals, alkenyloxy radicals, alkynyloxy radicals, lower alkylthio radicals, aminocarbonyl radicals, aminosulphonyl radicals or acylamino radicals; or R.sub.2 is a 1,4-benzodioxan-2-ylmethyl radical, R'.sub.2 is a hydrogen atom or a benzyl radical, R.sub.Type: GrantFiled: July 29, 1981Date of Patent: August 28, 1984Assignee: Boehringer Mannheim GmbHInventors: Helmut Michel, Wolfgang Kampe, Roland Ofenloch, Karl Dietmann, Gisbert Sponer
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Patent number: 4438128Abstract: The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamido, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R.sub.5 and R.sub.6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.Type: GrantFiled: June 15, 1981Date of Patent: March 20, 1984Assignee: Boehringer Mannheim GmbHInventors: Fritz Wiedemann, Wolfgang Kampe, Karl Dietmann, Gisbert Sponer
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Patent number: 4378363Abstract: This invention relates to new aminopropanol compounds having beta-adrenergic activity. In addition, the invention is directed to pharmaceutical compositions containing such compounds for the treatment of cardiac and circulatory infirmities and to methods for treating such infirmities.More particularly, the invention relates to new aminopropanol compound of the formula ##STR1## wherein R.sub.1 is a low alkyl moiety, which can be substituted, if desired, by a group Z-R.sub.5 ;R.sub.2 is hydrogen or a low alkanoyl group;R.sub.3 is a mono- or bicyclic heterocyclic compound having 1 to 2 hetero atoms, which can be mono- or polysubstituted, if desired, by halogen, amino, hydroxyl, low alkoxyl, low alkyl;R.sub.4 is hydrogen, a low alkanoyl group or an aroyl group;R.sub.Type: GrantFiled: November 17, 1980Date of Patent: March 29, 1983Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Wolfgang Kampe, Wolfgang Bartsch, Gisbert Sponer, Karl Dietmann
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Patent number: 4346093Abstract: The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl, hydroxyalkyl, alkoxycarbonyl or alkanoyloxyalkyl radicals or together represent an alkylene radical, R.sub.4 is a hydrogen atom or a lower alkanoyl radical or an aroyl radical, R.sub.5 is a hydrogen atom or a lower alkyl radical or an aralkyl radical, R.sub.6 is a hydrogen atom or a lower alkyl radical, R.sub.7 is a hydrogen atom, a hydroxyl group or a lower alkyl radical, Z is a valency bond, a methylene radical or an oxygen or sulphur atom, Ar is a carbocyclic aryl radical or a pyridyl radical, R.sub.8, R.sub.9 and R.sub.Type: GrantFiled: January 31, 1980Date of Patent: August 24, 1982Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Helmut Michel, Carl H. Ross, Fritz Wiedemann, Wolfgang Bartsch, Karl Dietmann
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Patent number: 4229464Abstract: New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: September 18, 1978Date of Patent: October 21, 1980Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Kurt Stach, deceased, by Werner Plattner, administrator, Max Thiel, Wolfgang Bartsch, Karl Dietmann, Egon Roesch, Wolfgang Schaumann
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Patent number: 4224438Abstract: Adenosine-5'-carboxylic acid derivatives of the general formula: ##STR1## wherein Z is two hydrogen atoms or a divalent lower alkylidene radical, ##STR2## R is an aliphatic or arylaliphatic radical, and R.sub.1 and R.sub.2 are independently a hydrogen, hydroxyl, amino, lower alkyl, lower alkenyl, optionally N-alkylated lower aminoalkyl, cycloalkyl, hydroxyalkyl or piperidinyl radical, orR.sub.1 and R.sub.2 taken together are a divalent ethylene radical containing 4-7 carbon atoms optionally interrupted by an oxygen or sulfur atom or by an imino, alkylimino or arylimino radical or a pharmacologically compatible salt thereof.The esters surprisingly can be prepared by esterifying the acid in the presence of sulfuric acid without hydrolyzing the sugar group. While the esters have some activity, they can be used to make the amides which are characterized by marked coronary activity.Type: GrantFiled: July 9, 1971Date of Patent: September 23, 1980Assignee: Boehringer Mannheim GmbHInventors: Erich Fauland, Wolfgang Kampe, Max Thiel, Karl Dietmann, Wolfgang Juhran
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Patent number: 4152446Abstract: New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof;Are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: June 10, 1977Date of Patent: May 1, 1979Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Kurt Stach, Max Thiel, Wolfgang Bartsch, Karl Dietmann, Egon Roesch, Wolfgang Schaumann
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Patent number: 4146630Abstract: A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z,Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl,R.sub.3 is hydrogen or --O--R.sub.8,R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl,R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl,X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z,or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.Type: GrantFiled: October 27, 1977Date of Patent: March 27, 1979Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Walter-Gunar Friebe, Fritz Wiedemann, Gisbert Sponer, Wolfgang Bartsch, Karl Dietmann
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Patent number: 4120963Abstract: New aminopropanol compounds of the formula ##STR1## wherein A is alkylene;B is sulfur or a valency bond;R is a straight-chained or branched lower alkyl; and the pharmacologically compatible salts thereof; are outstandingly effective adrenergic .beta.-receptor inhibitors and useful in the treatment or prophylaxis of circulatory diseases.Type: GrantFiled: May 19, 1977Date of Patent: October 17, 1978Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Martin Senn, Max Thiel, Wolfgang Bartsch, Karl Dietmann
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Patent number: 4087520Abstract: An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula ##STR1## wherein A is an alkylene radical which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, andR is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical,Or a pharmacologically compatible salt thereof. These compounds are outstanding in lowering blood pressure.Type: GrantFiled: March 9, 1976Date of Patent: May 2, 1978Assignee: Boehringer Mannheim GmbHInventors: Franz Braun, Kurt Stach, deceased, by Werner Plattner, executor, Max Thiel, Gisbert Sponer, Karl Dietmann
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Patent number: 4076829Abstract: New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen andThe pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: October 28, 1975Date of Patent: February 28, 1978Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Kurt Stach, Max Thiel, Wolfgang Bartsch, Karl Dietmann, Egon Roesch, Wolfgang Schaumann
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Patent number: 4070373Abstract: Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.Type: GrantFiled: September 22, 1972Date of Patent: January 24, 1978Assignee: C.F. Boehringer & Soehne GmbHInventors: Werner Winter, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator, Wolfgang Schaumann, Karl Dietmann
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Patent number: 4029783Abstract: New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.Type: GrantFiled: December 8, 1975Date of Patent: June 14, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Fritz Wiedemann, Max Thiel, Kurt Stach, Karl Dietmann, Gisbert Sponer
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Patent number: 4016262Abstract: N(6)-disubstituted adenosine compounds of the formula: ##STR1## wherein R.sub.1 is alkenyl, cycloalkenyl or cycloalkenyl-alkyl; andR.sub.2 is alkenyl, cycloalkenyl, straight or branched-chain alkyl, cycloalkyl, bicycloalkyl, alkyl-cycloalkyl, or alkyl-bicycloalkyl;And the pharmacologically compatible salts thereof; exhibit outstanding anti-lipolytic, anti-hyperlipaemic and anti-hypercholesterolaemic action.Type: GrantFiled: May 30, 1975Date of Patent: April 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Fauland, Wolfgang Kampe, Kurt Stach, deceased, by Werner Plattner, executor, Harald Stork, Karl Dietmann
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Patent number: 3998810Abstract: New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.Type: GrantFiled: July 10, 1974Date of Patent: December 21, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Fritz Wiedemann, Max Thiel, Kurt Stach, Karl Dietmann, Gisbert Sponer
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Patent number: 3976779Abstract: New 1,2,3,4-tetra-hydrocarbazole derivatives of the formula: ##SPC1##Wherein R.sup.1 is straight-chained or branched alkyl, and the pharmacologically compatible salts thereof, are markedly effective as inhibitors of adrogenic .beta.-receptors and thus useful for the treatment and prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: April 16, 1975Date of Patent: August 24, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Herbert Leinert, Alfred Popelak, Kurt Stach, Wolfgang Bartsch, Karl Dietmann
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Patent number: 3968129Abstract: New amine derivatives of azidophenols having the formula: ##EQU1## wherein R is straight-chained or branched alkyl;And the pharmacologically compatible salts thereof;Inhibit adrenogenic .beta.-receptors and are suitable for the treatment and prophylaxis of cardiac and circulatory diseases.Type: GrantFiled: January 28, 1975Date of Patent: July 6, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Wolfgang Kampe, Kurt Stach, Max Thiel, Wolfgang Bartsch, Karl Dietmann
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Patent number: 3947446Abstract: 1-[3-(5,6,7,8-TETRAHYDRONAPHTH-1-YLOXY)-PROPYL]-PIPERAZINE DERIVATIVES OF THE FORMULA ##SPC1##WhereinA is hydrogen or hydroxyl;X is hydrogen or halogen or alkyl, alkoxy, alkylthio, trifluoromethyl, hydroxyl, nitro, amino, acylamino (i.e., alkanoylamino) or alkylsulfonylamino; andn is 0, 1 or 2;And the pharmacologically compatible salts thereof; exhibit outstanding blood pressure depressing activity, i.e., possess antihypertensive properties.Type: GrantFiled: June 14, 1973Date of Patent: March 30, 1976Assignee: Boehringer Mannheim GmbHInventors: Ernst-Christian Witte, Kurt Stach, Karl Dietmann, Gisbert Sponer