Abstract: The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

Abstract: The present disclosure relates to compounds according to Formulae (I), (II) and (VIII), useful for treating diseases.

Abstract: The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

Abstract: The present disclosure relates to compounds according to Formulae (I), (II) and (VIII), useful for treating diseases.

Abstract: The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

Abstract: The subject invention provides a mixture of Crystalline Laquinimod sodium particles, wherein (i) ?90% of the total amount by volume of the laquinimod sodium particles have a size of ?40 ?m or (ii) ?50% of the total amount by volume of the laquinimod sodium particles have a size of ?15 ?m and wherein: a) the mixture has a bulk density of 0.2-0.4 g/mL; b) the mixture has a tapped density of 0.40-0.7 g/mL; c) an amount of heavy metal in the mixture is no more than 20 ppm relative to the amount by weight of laquinimod sodium; d) an amount of MCQ in the mixture is no more than 0.15% relative to the amount of laquinimod sodium as measured by HPLC; e) an amount of MCQCA in the mixture is no more than 0.15% relative to the amount of laquinimod sodium as measured by HPLC; or f) an amount of MCQME in the mixture is no more than 0.12% relative to the amount of laquinimod sodium as measured by HPLC.

Abstract: A method for preparing a compound of formula (I) by reacting the appropriate alkyl ester and an aniline derivative, in a refluxing mixture containing an aliphatic solvent or a mixture of aliphatic solvents having a boiling point in the range of 68-191° C.; condensing vapors of the refluxing mixture; treating the condensed vapors with an alcohol scavenging agent or a mixture of alcohol scavenging agents; and returning the condensed vapors back to the reaction mixture.

Abstract: A method for preparing a compound of formula (I) by reacting the appropriate alkyl ester and an aniline derivative, in a refluxing mixture containing an aliphatic solvent or a mixture of aliphatic solvents having a boiling point in the range of 68-191° C.; condensing vapors of the refluxing mixture; treating the condensed vapors with an alcohol scavenging agent or a mixture of alcohol scavenging agents; and returning the condensed vapors back to the reaction mixture.

Abstract: The present invention relates to a system and to an arrangement for evaluating in a defined space or area a delimited area (7) in which there is a degree of urgency greater than the degree of urgency in respect of the remainder of said space (1), wherein there is disposed within said space or area (1) a plurality of sensors which can evaluate the current or ongoing degree of urgency on the basis of one or more criteria. Selected sensors (2, 3, 4) shall be connected to computer equipment (50) which includes storage elements (52, 53, 54) adapted for storing current criteria-related values in a chosen time order, and wherein a calculating circuit (51) included in or connected to said computer equipment (50) is adapted for evaluation of a calculated degree of urgency on the basis of time-dependent changes in the evaluated current values, and determining and establishing the local orientation or geographic location of the delimited area through the medium of the calculating circuit.

Abstract: The present invention relates to a system and to an arrangement for evaluating in a defined space or area a delimited area (7) in which there is a degree of urgency greater than the degree of urgency in respect of the remainder of said space (1), wherein there is disposed within said space or area (1) a plurality of sensors which can evaluate the momentary degree of urgency on the basis of one or more criteria. Selected sensors (2, 3, 4) shall be connected to computer equipment (50) which includes storage elements (52, 53, 54) adapted for storing momentary criteria-related values in a chosen time order, and wherein a calculating circuit (51) included in or connected to said computer equipment (50) is adapted for evaluation of a calculated degree of urgency on the basis of time-dependent changes in the evaluated momentary values.

Abstract: The invention comprises a detector arrangement adjustable for inclusion in a preventive protective system for a process plant comprising at least two sensor units (10, 10′), a unit (16a, 16b) for evaluating the output signal of each sensor unit and a calculation unit (17) capable of co-operating with the evaluating units (16a, 16b), the output signals of which calculation unit can cause an activating unit (18) to pass from a first position to a second position. One or more of a first category of sensor units (10) is designed, via its circuit (16a) for evaluating output signals, to be able to determine the energy content of a particle present. One or more of a second category of sensor units (10′) is designed, via its circuit (16b) for evaluating output signals, to be able to determine the fire tendency or tendency to some other damage of the particle surroundings.

Abstract: The present invention relates to a system and to an arrangement for evaluating in a defined space or area a delimited area (7) in which there is a degree of urgency greater than the degree of urgency in respect of the remainder of said space (1), wherein there is disposed within said space or area (1) a plurality of sensors which can evaluate the current or ongoing degree of urgency on the basis of one or more criteria. Selected sensors (2, 3, 4) shall be connected to computer equipment (50) which includes storage elements (52, 53, 54) adapted for storing current criteria-related values in a chosen time order, and wherein a calculating circuit (51) included in or connected to said computer equipment (50) is adapted for evaluation of a calculated degree of urgency on the basis of time-dependent changes in the evaluated current values, and determining and establishing the local orientation or geographic location of the delimited area through the medium of the calculating circuit.

Abstract: The present invention relates to a system and to an arrangement for evaluating in a defined space or area a delimited area (7) in which there is a degree of urgency greater than the degree of urgency in respect of the remainder of said space (1), wherein there is disposed within said space or area (1) a plurality of sensors which can evaluate the momentary degree of urgency on the basis of one or more criteria. Selected sensors (2, 3, 4) shall be connected to computer equipment (50) which includes storage elements (52, 53, 54) adapted for storing momentary criteria-related values in a chosen time order, and wherein a calculating circuit (51) included in or connected to said computer equipment (50) is adapted for evaluation of a calculated degree of urgency on the basis of time-dependent changes in the evaluated momentary values.