Patents by Inventor Karl-Ernst Siegler

Karl-Ernst Siegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8420321
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: April 16, 2013
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Detlef Kozian, Stefan Schaefer, Bernward Schoelkens, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20120208200
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Application
    Filed: April 27, 2012
    Publication date: August 16, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef KOZIAN, Evi KOSTENIS, Karl-Ernst SIEGLER, Martina JACOBS, Jean-Francois DELEUZE, Sylvain RICARD, Sandrine MACE
  • Patent number: 8198022
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: June 12, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Detlef Kozian, Evi Kostenis, Karl-Ernst Siegler, Martina Jacobs, Sylvain Ricard, Sandrine Mace, Jean-Francois Deleuze
  • Patent number: 8084198
    Abstract: The use of the single nucleotide polymorphism (SNP) at position ?(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: December 27, 2011
    Assignee: Sanofi-Aventis
    Inventors: Detlef Kozian, Matthias Herrmann, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20110223628
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Application
    Filed: May 17, 2011
    Publication date: September 15, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef KOZIAN, Stefan SCHAEFER, Bernward SCHOELKENS, Karl-Ernst SIEGLER, Jean-Francois DELEUZE, Sylvain RICARD, Sandrine MACE
  • Patent number: 7985562
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: July 26, 2011
    Assignee: Sanofi-Aventis Deutsckland GmbH
    Inventors: Detlef Kozian, Stefan Schaefer, Bernward Schoelkens, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20110104704
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Application
    Filed: January 14, 2011
    Publication date: May 5, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef Kozian, Evi Kostenis, Karl-Ernst Siegler, Martina Jacobs, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Patent number: 7892744
    Abstract: The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: February 22, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Detlef Kozian, Joerg Czech, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Patent number: 7888020
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: February 15, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Detlef Kozian, Evi Kostenis, Karl-Ernst Siegler, Martina Jacobs, Sylvain Ricard, Sandrine Mace, Jean-Francois Deleuze
  • Publication number: 20100221714
    Abstract: The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
    Type: Application
    Filed: September 28, 2009
    Publication date: September 2, 2010
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef KOZIAN, Joerg CZECH, Karl-Ernst SIEGLER, Jean-Francois DELEUZE, Sylvain RICARD, Sandrine MACE
  • Publication number: 20100062431
    Abstract: The use of the single nucleotide polymorphism (SNP) of the ADAMTS4 gene for the identification of cardiovascular and peripheral vascular disorders or of an increased risk for developing cardiovascular and peripheral vascular disorders in a biological sample taken from an individual to be examined; the use of ADAMTS4 for identifying substances active in preventing and/or treating cardiovascular and peripheral vascular disorders and methods for doing so.
    Type: Application
    Filed: May 9, 2007
    Publication date: March 11, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Detlef Kozian, Matthias Herrmann, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20090239237
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Application
    Filed: May 29, 2009
    Publication date: September 24, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef KOZIAN, Stefan SCHAEFER, Bernward SCHOELKENS, Karl-Ernst SIEGLER, Jean-Francois DELEUZE, Sylvain RICARD, Sandrine MACE
  • Patent number: 7560290
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: July 14, 2009
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Detlef Kozian, Stefan Schaefer, Bernward Schoelkens, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20080312098
    Abstract: The use of the single nucleotide polymorphism (SNP) at position ?(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
    Type: Application
    Filed: May 3, 2006
    Publication date: December 18, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Detlef Kozian, Matthias Herrmann, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20070292859
    Abstract: The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a sample. Moreover, probes, primers, polypeptides or polynucleotides suitable for said methods are claimed.
    Type: Application
    Filed: August 27, 2005
    Publication date: December 20, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Detlef Kozian, Heinz Goegelein, Karl-Ernst Siegler, Martina Jacobs, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Patent number: 7262273
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: August 28, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Detlef Kozian, Evi Kostenis, Karl-Ernst Siegler, Martina Jacobs, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20060040296
    Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
    Type: Application
    Filed: April 1, 2004
    Publication date: February 23, 2006
    Inventors: Detlef Kozian, Stefan Schaefer, Bernward Schoelkens, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20050019795
    Abstract: The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
    Type: Application
    Filed: April 23, 2004
    Publication date: January 27, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Detlef Kozian, Joerg Czech, Karl-Ernst Siegler, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace
  • Publication number: 20030219808
    Abstract: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
    Type: Application
    Filed: March 21, 2003
    Publication date: November 27, 2003
    Inventors: Detlef Kozian, Evi Kostenis, Karl-Ernst Siegler, Martina Jacobs, Jean-Francois Deleuze, Sylvain Ricard, Sandrine Mace