Patents by Inventor Karl F. Kovacs
Karl F. Kovacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7053193Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.Type: GrantFiled: January 25, 2002Date of Patent: May 30, 2006Assignee: Origene Technologies, Inc.Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Patent number: 6953673Abstract: The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.Type: GrantFiled: December 18, 2001Date of Patent: October 11, 2005Assignee: Origene Technologies, Inc.Inventors: Karl F. Kovacs, Gilbert Jay
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Publication number: 20040249144Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic/science and medicine, etc. The polynucleotides are differentially-regulated in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, predisposition to, etc., diseases and conditions relating to breast cancer.Type: ApplicationFiled: April 5, 2004Publication date: December 9, 2004Inventors: Zairen Sun, Xuan Li, Gilbert Jay, Karl F. Kovacs, Wufang Fan
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Patent number: 6780595Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: GrantFiled: February 26, 2002Date of Patent: August 24, 2004Assignee: Origene Technologies, Inc.Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030190625Abstract: The present invention relates to human kidins220Pc, including all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are up-regulated in prostate cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., prostate cancer. Human kidins220Pc is also involved in neurite outgrowth, making it a target for therapeutic approaches to neurodegenerative diseases, such as spinal cord injury.Type: ApplicationFiled: April 8, 2002Publication date: October 9, 2003Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030186249Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are highly in brain, pituitary, muscle, and thymus, and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, relating to such tissues. The genes and polypeptides can also be used as markers for immature T-cells.Type: ApplicationFiled: April 1, 2002Publication date: October 2, 2003Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030180728Abstract: The present invention relates to all facets of a novel polynucleotide, BCU399, the polypeptides it encodes, antibodies, and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are upregulated in breast cancer and expressed in adrenal, thyroid, brain, kidney, lung, ovary, prostate, testis and breast tissues, and are therefore useful in a variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to cancer, especially relating to breast tissue, as well as diseases and conditions such as febrile seizures, Wagner's syndrome, Usher syndrome, etc.Type: ApplicationFiled: March 22, 2002Publication date: September 25, 2003Inventors: Karl F. Kovacs, Xuan Li, Gilbert Jay, Zairen Sun, Wufang Fan
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Publication number: 20030162177Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.Type: ApplicationFiled: February 26, 2002Publication date: August 28, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030148407Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are modulated during angiogeneis and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, determining predisposition to, etc., diseases and conditions, such as abnormal, insufficient, excessive, etc.Type: ApplicationFiled: February 7, 2002Publication date: August 7, 2003Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030143546Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.Type: ApplicationFiled: January 25, 2002Publication date: July 31, 2003Inventors: Zairen Sun, Wufang Fan, Karl F. Kovacs, Xuan Li, Gilbert Jay
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Publication number: 20030113839Abstract: The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.Type: ApplicationFiled: December 18, 2001Publication date: June 19, 2003Inventors: Karl F. Kovacs, Gilbert Jay
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Publication number: 20030096271Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain and pancreas.Type: ApplicationFiled: July 15, 2002Publication date: May 22, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay
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Publication number: 20030092036Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain and pancreas.Type: ApplicationFiled: July 15, 2002Publication date: May 15, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay
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Publication number: 20030078199Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides and polypeptides are related to EphA6, and are expressed in brain, pancreas, and testes tissues and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, especially relating to brain, pancreas, and testes tissues.Type: ApplicationFiled: October 9, 2001Publication date: April 24, 2003Inventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Xuan Li, Gilbert Jay
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Patent number: 6455292Abstract: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.Type: GrantFiled: August 16, 2001Date of Patent: September 24, 2002Assignee: OriGene Technologies, IncInventors: Youmin Shu, Wufang Fan, Karl F. Kovacs, Michael Zidanic, Gilbert Jay