Patents by Inventor Karl Franzmann

Karl Franzmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9862691
    Abstract: A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): Each of A, N*, X, Y, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: January 9, 2018
    Assignee: University of Greenwich
    Inventors: Michael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann
  • Publication number: 20160311784
    Abstract: A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): Each of A, N*, X, Y, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
    Type: Application
    Filed: July 5, 2016
    Publication date: October 27, 2016
    Applicant: University of Greenwich
    Inventors: Michael LEACH, Laurence HARBIGE, Dieter RIDDALL, Karl FRANZMANN
  • Patent number: 9422253
    Abstract: A method of treating a disorder such as epilepsy, multiple sclerosis, glaucoma and uveitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia, or trigeminal autonomic cephalalgias. The method includes administering to a subject in need thereof substituted 1,2,4-triazine compounds of formula (I): Each of A, N*, X, Y, Z, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: August 23, 2016
    Assignee: UNIVERSITY OF GREENWICH
    Inventors: Michael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann
  • Patent number: 9000155
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system, or a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: April 7, 2015
    Assignee: University Of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Publication number: 20140243343
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system, or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: April 30, 2014
    Publication date: August 28, 2014
    Applicant: University of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Patent number: 8748600
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ?NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: June 10, 2014
    Assignee: University of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Patent number: 8748599
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula (I): in which z is a single bond or an optionally substituted linking group, R1 is a halo-alkyl group; and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system; or a salt thereof.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: June 10, 2014
    Assignee: University Of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Publication number: 20140155403
    Abstract: A method of treating a disorder. The method includes administering to a subject in need thereof a compound of formula (I): Each of A, N*, X, Y, Z, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 5, 2014
    Applicant: University of Greenwich
    Inventors: Michael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann
  • Patent number: 8691818
    Abstract: Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ?NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic infl
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: April 8, 2014
    Assignee: University Of Greenwich
    Inventors: Michael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann
  • Publication number: 20120135993
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ?NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof.
    Type: Application
    Filed: July 8, 2010
    Publication date: May 31, 2012
    Applicant: University of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Publication number: 20120135992
    Abstract: The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula (I): in which z is a single bond or an optionally substituted linking group, R1 is a halo-alkyl group; and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system; or a salt thereof.
    Type: Application
    Filed: July 8, 2010
    Publication date: May 31, 2012
    Applicant: University of Greenwich
    Inventors: Michael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
  • Publication number: 20110009413
    Abstract: Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ?NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic infl
    Type: Application
    Filed: January 16, 2009
    Publication date: January 13, 2011
    Applicant: UNIVERSITY OF GREENWICH
    Inventors: Michael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann