Patents by Inventor Karl G. Grozinger

Karl G. Grozinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical suspension comprising nevirapine hemihydrate
    Patent number: 6255481
    Abstract: An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: July 3, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Amale A. Hawi
  • Pharmaceutical suspension comprising nevirapine hemihydrate
    Patent number: 6172059
    Abstract: An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: January 9, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Amale A. Hawi
  • Method for the preparation of 3-amino-2-chloro-4-methylpyridines
    Patent number: 5668287
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: September 16, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • 5,11-dihyro-6H-dipyrido[3,2-B:2',3'-e][1,3]diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5620974
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: April 15, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Process for the preparation of pure enantiomers of 1-(2-pyridyl)-2-cyclohexylethylamine
    Patent number: 5616717
    Abstract: Racemic mixtures of 1-(S,R)-(2-pyridyl)-2-cyclohexylethylamine are separated into (+)-(S)-1-(2-pyridyl)-2-cyclohexylethylamine or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine by admixture with (+)- or (-)-3-bromocamphor-8-sulfonic acid. 1-(S)-(2-pyridyl)-2-cyclohexylethylamine is an intermediate in the preparation of leukotriene biosynthesis inhibitors.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: April 1, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Karl G. Grozinger
  • Pyridobenzo- and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5602113
    Abstract: Disclosed are novel pyrido[2,3,-b][1,5]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: February 11, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Pyridobenzo-and pyridiothieno-diazepines useful for the treatment of HIV infection
    Patent number: 5593979
    Abstract: Disclosed are novel pyrido[2,3-b][1,4]benzodiazepines. These compounds are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: January 14, 1997
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
    Patent number: 5571912
    Abstract: This invention relates to a novel method for preparing certain dipyrido-diazepines.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: November 5, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Dipyrido[3,2-B:2 ',3'-E][1,4]Diaqzepines and their use in the treatment of HIV infection
    Patent number: 5550117
    Abstract: Disclosed are novel dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the treatment of HIV-1 infection.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: August 27, 1996
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, Ernest Cullen, John R. Proudfoot, Karl G. Grozinger, Kollol Pal, Julian Adams
  • 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
    Patent number: 5366972
    Abstract: Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: November 22, 1994
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl D. Hargrave, John R. Proudfoot, Julian Adams, Karl G. Grozinger, Gunther Schmidt, deceased, Wolfhard Engel, Gunther Trummlitz, Wolfgang Eberlein
  • Method for preparing 3-amino-2-chloro-4-alkylpyridines
    Patent number: 5200522
    Abstract: A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of the formula: ##STR1## wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 6, 1993
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, Karl D. Hargrave, Julian Adams
  • Anti-inflammatory thienylbenzylamine compounds
    Patent number: 5030647
    Abstract: Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: July 9, 1991
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Clara K. Miao, Karl G. Grozinger, Robert Rothlein, Ronald Faanes, Genus Possanza, John P. Devlin
  • Diazine-ethenylphenyl oxamic acids and esters and salts thereof
    Patent number: 4886801
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or NHCOCOOR.sub.1 ;R.sub.3 is hydrogen or NHCOCOOR.sub.1 ;A is ##STR2## R.sub.4 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)-amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; andR.sub.5 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or NHCOCOOR.sub.1 ;and, when R.sub.1 is hydrogen, nontoxic, pharmaceutically acceptable salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders such as asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.
    Type: Grant
    Filed: September 12, 1988
    Date of Patent: December 12, 1989
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Karl G. Grozinger, James T. Oliver
  • Diazine-ethyenylphenyl oxamic acids and esters and salts thereof
    Patent number: 4788198
    Abstract: Compounds of the formula ##STR1## R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or NHCOCOOR.sub.1 ;R.sub.3 is hydrogen or NHCOCOOR.sub.1 ;A is ##STR2## R.sub.4 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)-amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; andR.sub.5 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or NHCOCOOR.sub.1 ;and, when R.sub.1 is hydrogen, nontoxic, pharmaceutically acceptable salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders such as asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: November 29, 1988
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, James T. Oliver
  • Diazine-ethenylphenyl oxamic acids and esters and salts thereof
    Patent number: 4681884
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.2 is hydrogen, methyl, hydroxyl, alkoxy of 1 to 4 carbon atoms, di(alkyl of 1 to 2 carbon atoms)amino-(alkoxy of 1 to 4 carbon atoms) or NHCOCOOR.sub.1 ;R.sub.3 is hydrogen or NHCOCOOR.sub.1 ;A is ##STR2## R.sub.4 is hydrogen, methyl, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, alkanoyloxy of 1 to 2 carbon atoms, di(alkyl of 1 to 2 carbon atoms)-amino-(alkoxy of 1 to 4 carbon atoms) or acetamido; andR.sub.5 is hydrogen, amino, alkoxy of 1 to 4 carbon atoms, halogen or NHCOCOOR.sub.1 ;and, when R.sub.1 is hydrogen, nontoxic, pharmaceutically acceptable salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders such as asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies and the like.
    Type: Grant
    Filed: May 10, 1985
    Date of Patent: July 21, 1987
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Karl G. Grozinger, James T. Oliver