Patents by Inventor Karl Groke

Karl Groke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7855191
    Abstract: Disclosed is an agent which has a destructive effect on malignant tumors and contains alpha-ketoglutaric acid, N-acetyl-seleno-L-methionine, N-acetyl-L-methionine, and a compound that is capable of forming azomethine and is selected among the group 5-hydroxymethylfurfural, dehydroascorbic acid, maltol, and vanillin as an active substance, 5-hydroxymethylfurfural being preferred. The inventive agent can be used in the form of an infusion, in an oral or rectal form of administration, or as an irrigation in cancer therapy.
    Type: Grant
    Filed: October 13, 2003
    Date of Patent: December 21, 2010
    Assignees: C.Y.L. Pharmazeutika GmbH
    Inventors: Karl Groke, Ilse Groke, legal representative, Veronika Groke, legal representative, Paul Groke, legal representative, Ralf Herwig, Peter Ferdinand
  • Publication number: 20060292218
    Abstract: Disclosed is an agent which has a destructive effect on malignant tumors and contains alpha-ketoglutaric acid, N-acetyl-seleno-L-methionine, N-acetyl-L-methionine, and a compound that is capable of forming azomethine and is selected among the group 5-hydroxymethylfurfural, dehydroascorbic acid, maltol, and vanillin as an active substance, 5-hydroxymethylfurfural being preferred. The inventive agent can be used in the form of an infusion, in an oral or rectal form of administration, or as an irrigation in cancer therapy.
    Type: Application
    Filed: October 13, 2003
    Publication date: December 28, 2006
    Inventors: Karl Groke, Ilse Groke, Veronika Groke, Paul Groke, Ralf Herwig, Peter Ferdinand
  • Publication number: 20050274391
    Abstract: The invention relates to a means for weaning people off smoking or alcohol, said means containing alpha-Ketoglutaric acid and 5-hydroxymethylfurfural, preferably in a mass ratio of between 2:1 and 12:1. Preferably, said means is in the form of a drink containing the following constituents per litre: between 4 and 8 g of alpha-Keloglutaric acid; between 0.2 and 0.6 g of 5-hydroxymethylfurfural; between 20 and 40 g of saccharose; between 2.5 and 5 g of sodium carbonate; between 0.3 and 0.8 g of sorbic acid; and optionally up to 0.5 g of citric acid. The pH value is equal to between 4 and 5.
    Type: Application
    Filed: May 15, 2003
    Publication date: December 15, 2005
    Inventors: Karl Groke, Ernst Kager, Christian Bucher
  • Patent number: 5554618
    Abstract: An intravenously administrable, aqueous solution of a water-soluble, physiologically tolerable salt of sulfametrole and of trimethoprim, in which malic acid, L-serine and/or L-threonine are present as solubilizers, and which has a pH of of 6.5-7.0 is disclosed.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: September 10, 1996
    Assignee: Hafslund Nycomed Pharma Aktiengesellschaft
    Inventor: Karl Groke
  • Patent number: 5006551
    Abstract: An agent having a destructive effect on malignant tumors and containing as active substances alpha-ketoglutaric acid and 5-hydroxymethylfurfural is described. The agent can be used in cancer therapy both in the form of an infusion solution and as a form for oral or rectal administration or as a douche or ointment.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: April 9, 1991
    Assignee: Leopold & Co., Chem. Pharm. Fabrik Aktiengesellschaft
    Inventors: Karl Groke, Hans Miggitsch, Horst Musil, Josef Polzer
  • Patent number: 4960108
    Abstract: Improved laser-induced shockwave lithotripsy in which pulsed laser radiation situated in the infrared region is concentrated by means of an optical wave guide at a concrement to be destroyed which is surrounded with an aqueous rinsing liquid. The concrement is destroyed mechanically by laser-induced breakdown of the rinsing liquid, giving rise to shockwave and cavitation. The improvement resides in the presence in the rinsing liquid of a metal compound selected from the group consisting of water-soluble salts of metals of the ferrous group of the periodic table, complex compounds of said metals of the ferrous group of the periodic table, water-soluble salts of magnesium and water-soluble salts of calcium, the metal compounds being present in a concentration not exceeding 50 mmol/l, relative to their metal content. The presence of the metal compounds lowers the energy required for said breakdown.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: October 2, 1990
    Assignee: Leopold & Co. Chem. Pharm. Fabrik Gesellschaft M.B.H.
    Inventors: Erich Reichel, Heinz Schmidt-Kloiber, Karl Groke
  • Patent number: 4434160
    Abstract: A nutrient solution for complete parenteral feeding and for increased energy production, for administration to patients in the post-aggression phase, which contains, in aqueous solution, per 25 parts by weight of an aminoacid mixture, at most 50 parts by weight of glucose or glucose substitutes or both, and 0.8-1.2 parts by weight of L-carnitine in the form of one of its salts. Preferably, the solution also contains electrolytes.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: February 28, 1984
    Assignee: Leopold & Co. Chem. Pharm. Fabrik Gesellschaft m.b.H.
    Inventors: Stojan Jeretin, Karl Groke, Horst E. Musil
  • Patent number: 4327084
    Abstract: Clear aqueous solution capable for intravenous administration comprising 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine as a sulphonamide potentiator, a water-soluble medicinally-acceptable salt of 3-methoxy-4-(4'-aminobenzol-sulphonamido)-1,2,5-thiadiazole and from about 5 to about 40% by weight of a compound selected from the group consisting of sugar-alcohols having 5 or 6 carbon atoms, glucose and fructose, which solution has a pH-value within the range of 6 to 8.
    Type: Grant
    Filed: October 26, 1979
    Date of Patent: April 27, 1982
    Assignee: Chemie Linz Aktiengesellschaft
    Inventor: Karl Groke