Abstract: There is described a process for the production of theophylline derivatives of the formula ##STR1## where T is the theophyllinyl-(7)-residue, Alk is a straight or branched alkylene chain having 2 to 4 carbon atoms, R is hydrogen or a methyl group, n is 1 or 2 with the proviso that two hydroxy groups of the phenyl ring cannot be in the 3,4-positions by reacting an aminoalkyltheophylline of the formula ##STR2## with a bromoketone of the formula ##STR3## where R' is a lower alkyl group and the two --OCOR' groups of the phenyl ring cannot be in the 3,4 positions to an intermediate compound of the formula ##STR4## and subsequently hydrolytically splitting off the R'CO protective group wherein the bromoketone of formula III is produced free of dibromide by bromination of a ketone of the formula ##STR5## followed by treatment with a lower trialkyl phosphite.

Abstract: Optically active bases are prepared by reacting the racemic base with an optically active half amide of an unsaturated aliphatic dicarboxylic acid of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same of different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of R.sub.1, R.sub.2 and R.sub.3 together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or a C.sub.1 -C.sub.4 alkyl group and n is 0 or 1 and optionally splitting an optically homogeneous salt fraction into the corresponding optically active base and the added half amide.

Abstract: There are prepared compounds of the formula ##STR1## in which T is the theophyllin-7-yl group and alk is a straight or branched alkylene chain with 2 to 4 carbon atoms and salts thereof. The compounds promote circulation and produce a marked and persistent increase in renal circulation.

Abstract: There are prepared compounds corresponding to the general formulaT -- Alk -- NH -- CH.sub.2 -- CH(OH) -- CH.sub.

Abstract: There are prepared quaternary xanthinylalkylnortropine derivatives of the general formula I ##STR1## where T represents a theophyllinyl-7 radical or a theobrominyl-(1)-radical, Alk is a straight or branched chain alkylene group having 2 to 10 carbon atoms or such a group substituted by a hydroxyl group, R is an alkyl group of 1 to 4 carbon atoms and A.sup.(-) is an equivalent to an anion of a physiologically compatible mono- or polyvalent acid. The compounds are useful as medicines having a spasmolytic activity.