Patents by Inventor Karl H. Michel

Karl H. Michel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5571901
    Abstract: Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 5, 1996
    Assignee: DowElanco
    Inventors: LaVerne D. Boeck, Hang Chio, Tom E. Eaton, Otis W. Godfrey, Jr., Karl H. Michel, Walter M. Nakatsukasa, Raymond C. Yao
  • Patent number: 5496931
    Abstract: Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: March 5, 1996
    Assignee: DowElanco
    Inventors: LaVerne D. Boeck, Hang Chio, Tom E. Eaton, Otis W. Godfrey, Jr., Karl H. Michel, Walter M. Nakatsukasa, Raymond C. Yao
  • Patent number: 5362634
    Abstract: Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
    Type: Grant
    Filed: October 10, 1991
    Date of Patent: November 8, 1994
    Assignee: DowElanco
    Inventors: LaVerne D. Boeck, Hang Chio, Tom E. Eaton, Otis W. Godfrey, Jr., Karl H. Michel, Walter M. Nakatsukasa, Raymond C. Yao
  • Patent number: 5286631
    Abstract: Newly-discovered antibiotic A10255 factors B, C, E, and F are produced by submerged aerobic fermentation of previously-unknown Streptomyces gardneri strain NRRL 15922, or an A10255-producing variant, mutant or recombinant thereof. The antibiotics are active against a wide variety of pathogenic bacteria, and also enhance feed-utilization efficiency in chickens, weanling pigs and cattle.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: February 15, 1994
    Assignee: Eli Lilly and Company
    Inventors: LaVerne D. Boeck, Otis W. Godfrey, Jr., Karl H. Michel
  • Patent number: 5286648
    Abstract: Newly discovered lipoglycopeptide antibiotic A84575 complex, comprising factors A, B, C, D, E, F, G, and H, is produced by submerged aerobic fermentation of a culture selected from Streptosporangeum carneum NRRL 18437, Streptosporangeum carneum NRRL 18505 or an A84575-producing mutant thereof. The antibiotics are active against Gram-positive bacteria.
    Type: Grant
    Filed: June 27, 1991
    Date of Patent: February 15, 1994
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Raymond C. Yao
  • Patent number: 5239064
    Abstract: A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.
    Type: Grant
    Filed: April 11, 1990
    Date of Patent: August 24, 1993
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hoehn, Karl H. Michel, Raymond C. Yao
  • Patent number: 5229362
    Abstract: Newly-discovered antibiotic A10255 factors B, C, E, F, G, H, and J are produced by submerged aerobic fermentation of Streptomyces gardneri NRRL 15537 and NRRL 18260 or an A10255-producing variant or mutant thereof. The antibiotics are active against a wide variety of pathogenic bacteria, and also enhance feed-utilization efficiency in chickens, weanling pigs, cattle and sheep. The antibiotics can also be used to detect the thiostrepton-resistance gene in Streptomyces species.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: July 20, 1993
    Assignee: Eli Lilly and Company
    Inventors: Herbert A. Kirst, Karl H. Michel
  • Patent number: 4880735
    Abstract: Improved fermentation process for producing the Gram-positive antibiotic A47934 which comprises cultivating a new strain of Streptomyces toyocaensis, NRRL 18112, and a biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 24, 1986
    Date of Patent: November 14, 1989
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Michael D. Jones, Karl H. Michel, Raymond C. Yao, Milton J. Zmijewski
  • Patent number: 4713331
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: December 15, 1987
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4663282
    Abstract: New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: May 2, 1985
    Date of Patent: May 5, 1987
    Assignee: Eli Lilly and Company
    Inventors: LaVerne D. Boeck, Gladys M. Clem, Charles L. Hershberger, Marie T. Anderson, Karl H. Michel
  • Patent number: 4604239
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: August 5, 1986
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4563442
    Abstract: New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B.sub.1, B.sub.2, B.sub.3, C.sub.1, C.sub.2, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N, O and actaplanin .psi.aglycone, and salts thereof, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: January 7, 1986
    Assignee: Eli Lilly and Company
    Inventors: Gladys M. Clem, LaVerne D. Boeck, Marie T. Anderson, Karl H. Michel
  • Patent number: 4559323
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: December 17, 1985
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4548924
    Abstract: Antibiotics M43B and M43C, new glycopeptide antibiotics of the vancomycin class, are produced by Nocardia orientalis NRRL 2452. M43B and M43C have antibacterial activity.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 22, 1985
    Assignee: Eli Lilly and Company
    Inventor: Karl H. Michel
  • Patent number: 4537770
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antiobiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4537777
    Abstract: New A52688 factors A, C, D, E, F, G, H, J and K which have the common general formula: ##STR1## are antibacterial and antineoplastic agents. Methods of preparing the antibiotics by culturing a strain of Mycoleptodiscus terrestris are provided.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: Marie T. Anderson, Karl H. Michel, Thomas H. Sands
  • Patent number: 4537715
    Abstract: New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: LaVerne D. Boeck, Gladys M. Clem, Charles L. Hershberger, Marie T. Anderson, Karl H. Michel
  • Patent number: 4492650
    Abstract: Antibiotic A54556, a complex of 8 individual factors, produced by submerged, aerobic fermentation of new Streptomyces hawaiiensis NRRL 15010. The complex and the individual, separated factors are active against Staphylococcus and Streptococcus which are penicillin resistant.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: January 8, 1985
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4431809
    Abstract: Antibiotic A-33853 is produced by submerged, aerobic fermentation of a new Streptomyces sp. NRRL 12068. The antibiotic and the diacetyl and triacetyl derivatives thereof disclosed herein have shown antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic and its tetraacetyl derivative have shown antiviral and antitrichomonal activity in vitro.
    Type: Grant
    Filed: May 7, 1982
    Date of Patent: February 14, 1984
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hoehn, Karl H. Michel
  • Patent number: 4400510
    Abstract: Antibiotic A-32256 which is produced by submerged, aerobic fermentation of a Streptomyces sp. NRRL 12067. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus and various anaerobic species. In addition, the antibiotic has shown antitrichomonas activity in vitro, as well as activity for improving ruminant feed efficency and as a mosquito larvacide.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: August 23, 1983
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Marvin M. Hoehn