Patents by Inventor Karl H. Pegel

Karl H. Pegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5166194
    Abstract: The invention relates to novel transdermally applicable pharmaceutical preparations containing glycosides; a solvent selected from the group consisting of ethoxylated sterols and ethoxylated alcohols with 12 to 30 carbon atoms; and lipophilic ointment base.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: November 24, 1992
    Assignee: Roecar Holdings
    Inventors: Hans Walker, Karl H. Pegel
  • Patent number: 5128324
    Abstract: The invention relates to novel, transdermally applicable pharmaceutical preparations including sterolines or spiroketalines, a solvent selected from the group consisting of ethoxylated sterols and C12-C30 alcohols, and lipophilic ointment base. Methods of treatment using same.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: July 7, 1992
    Assignee: Roecar Holdings
    Inventors: Hans Walker, Karl H. Pegel
  • Patent number: 5008471
    Abstract: As a process for preparing a compound of the formula ##STR1## in which both Rs are H or --OH comprising the steps: a. of treating the ethyl ester of caffeic acid with a trialkylsilyl chloride at ambient conditions in equimolar proportions in the presence of a base;b. of reduction of the resulting product with an aluminium hydride reagent at sub-zero temperature and equimolar proportions to yield the corresponding allylic alcohol;c. of halogenation of this allylic alcohol with thionyl chloride or a phosphorus trihalide to yield the corresponding allyl halide;d. of coupling this allyl halide with the silyl ether of compound of the formula ##STR2## in refluxing ether solutions; and e. of hydrolysis of this coupled product with tetra alkyl ammonium flouride at ambient conditions and of equimolar proportions.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: April 16, 1991
    Assignee: Rooperol (N.A.)
    Inventors: George L. Wenteler, Karl H. Pegel, Siegfried Drews, Hans Kundig
  • Patent number: 4929603
    Abstract: The invention relates to the use of phytosteryl glycoside or their esters for the treatment of conditions caused by increased endogenous epoxycholesterol levels in human organs and organ fluids especially those with glandular function; and to compositions and method for treating such conditions.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: May 29, 1990
    Assignee: Rooperal (NA) NV
    Inventors: Karl H. Pegel, Hans Walker
  • Patent number: 4265886
    Abstract: The present invention provides a pharmaceutical composition, primarily for the treatment of inflammatory conditions, including benign prostata hypertrophy, the composition containing a spiroketalin such as diosgenyl-.beta.-D-glycoside or hecogenyl-.beta.-D-glycoside. A unit dosage form is provided which contains between 0,3 and 0,75 mgm of the spiroketalin.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: May 5, 1981
    Assignee: Roecar Holdings (Netherlands Antilles (NV)
    Inventor: Karl H. Pegel
  • Patent number: 4260603
    Abstract: Medicaments are prepared having activity as prostaglandin synthetase inhibitor comprising certain sterol glycosides, a fatty acid ester thereof or a spiroketal-steroid glucoside or fatty acid ester thereof in an amount sufficient to inhibit a prostaglandin synthetase.
    Type: Grant
    Filed: January 2, 1979
    Date of Patent: April 7, 1981
    Inventors: Karl H. Pegel, Hans Walker
  • Patent number: 4254111
    Abstract: The invention is concerned with new chemical compounds being the hemiesters of steryl glycosides, methods of preparing these hemiesters, and pharmaceutically, particularly anti-inflammatory, compositions containing the new hemiesters.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: March 3, 1981
    Assignee: Roecar Holdings (Netherlands Antilles) NV
    Inventors: Karl H. Pegel, Colin B. Rogers
  • Patent number: 4198401
    Abstract: Plant material derived from the family Hypoxidaceae is heated at a temperature of at least 60.degree. C. for a sufficient period to ensure enzyme destruction and is then extracted at a temperature of 0.degree.-30.degree. C. with aqueous alcohol containing 30-75 volume percent ethanol for about 1 to 15 days to obtain a pharmaceutically active material.
    Type: Grant
    Filed: March 1, 1979
    Date of Patent: April 15, 1980
    Inventor: Karl H. Pegel
  • Patent number: 4188379
    Abstract: Sterol glycosides and esters thereof with monocarboxylic acids of natural or synthetic origin are used to combat human and animal illness in dosages of not over 10 mg per day.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: February 12, 1980
    Assignee: Roecar Holdings (Netherlands Antilles) N.V.
    Inventor: Karl H. Pegel
  • Patent number: 4160860
    Abstract: Plant material derived from the family Hypoxidaceae is heated at a temperature of at least 60.degree. C. for a sufficient period to ensure enzyme destruction and is then extracted at a temperature of 0.degree.-30.degree. C. with aqueous alcohol containing 30-75 volume percent ethanol for about 1 to 15 days to obtain a pharmaceutically active material.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: July 10, 1979
    Assignee: Roecar Holdings (Netherlands Antilles) N.V.
    Inventor: Karl H. Pegel