Abstract: The invention relates to a process for the preparation of an injectable chondroitin polysulfate, which is characterized in thatA crude chondroitin polysulfate is depolymerized oxidatively,B the depolymerized chondroitin polysulfate is bleached, if necessary, with peracetic acid,C the product obtained after A or B is subjected once or twice to precipitation with methanol and/or ultrafiltration for fractionation with respect to molecular weight,D the product obtained after C is demineralized, if necessary, with cation exchangers, andE the product obtained after C or D is decolorized, if necessary, with active charcoal.The invention furthermore relates to a chondroitin polysulfate which can be prepared by the above process. The invention also relates to a chondroitin polysulfate with an acute toxicity (LD.sub.50), on intravenous administration, of >3,500 mg/kg in NMRI mice, of >3,000 mg/kg in Wistar rats, of >1,000 mg/kg in cats and of >1,000 mg/kg in dogs.