Patents by Inventor Karl Hardman

Karl Hardman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent antigen-binding proteins
    Publication number: 20060063715
    Abstract: Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.
    Type: Application
    Filed: September 29, 2005
    Publication date: March 23, 2006
    Inventors: Marc Whitlow, James Wood, Karl Hardman, Robert Bird, David Filpula, Michele Rollence
  • Immunoaffinity purification methods using single polypeptide chain binding molecules
    Patent number: 5534621
    Abstract: The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 9, 1996
    Assignee: Enzon Labs, Inc.
    Inventors: Robert C. Ladner, Robert E. Bird, Karl Hardman
  • Immunoassay methods using single polypeptide chain binding molecules
    Patent number: 5518889
    Abstract: The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 21, 1996
    Assignee: Enzon Labs Inc.
    Inventors: Robert C. Ladner, Robert E. Bird, Karl Hardman
  • Immunotheraphy using single chain polypeptide binding molecules
    Patent number: 5455030
    Abstract: The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: October 3, 1995
    Assignee: Enzon Labs, Inc.
    Inventors: Robert C. Ladner, Robert E. Bird, Karl Hardman
  • Single polypeptide chain binding molecules
    Patent number: 5260203
    Abstract: The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: November 9, 1993
    Assignee: Enzon, Inc.
    Inventors: Robert C. Ladner, Robert E. Bird, Karl Hardman
  • Single polypeptide chain binding molecules
    Patent number: 4946778
    Abstract: The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
    Type: Grant
    Filed: January 19, 1989
    Date of Patent: August 7, 1990
    Assignee: Genex Corporation
    Inventors: Robert C. Ladner, Robert E. Bird, Karl Hardman