Patents by Inventor Karl-Heinz Botsch

Karl-Heinz Botsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4081329
    Abstract: Carrier-bound macromolecular compounds, especially bioactive macromolecular compounds, are produced by reacting a macromolecular compound A with a coupling compound B containing at least one reactive function capable of coupling with compound A and at least one further reactive function capable of polymerization, adding to the resulting coupled reaction product AB an unswollen molecular sieve material having cross-linking sufficient to exclude penetration by compound A, and polymerizing the polymerizable group of the coupled product AB in the molecular sieve material to form a polymer body in the molecular sieve material and fix compound A on the surface of the molecular sieve material. Compound A can be, e.g., an enzyme, antibody or hormone, and coupling compound B typically contains, as the coupable function, an alkylation or acylation group such as oxirane, ethyleneimine, halide, acid halide, azide or anhydride groups, and, as the polymerizable function, a carbon-carbon or carbon-oxygen double bond.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: March 28, 1978
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dieter Jaworek, Karl-Heinz Botsch, Gunter Weimann, Michael Nelbock-Hochstetter, Helmut Determann
  • Patent number: 3969287
    Abstract: Carrier-bound proteins are prepared by reacting a protein in aqueous solution with a coupling compound having at least one group capable of acylating or alkylating proteins and at least one additional group capable of producing a bond with a carrier material, and reacting the resulting product with a carrier material, optionally forming the carrier material in situ by polymerization of a monomer or monomer mixture in the presence of said product.
    Type: Grant
    Filed: November 30, 1973
    Date of Patent: July 13, 1976
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dieter Jaworek, Michael Nelbock-Hochstetter, Klaus Beaucamp, Hans Ulrich Bergmeyer, Karl-Heinz Botsch