Patents by Inventor Karl-Heinz Koelker

Karl-Heinz Koelker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200261006
    Abstract: A method for manufacturing a sensor for detecting an analyte in a body fluid is disclosed. In the inventive method a membrane layer is provided, and at least one first electrically conductive material is directly or indirectly deposited onto the membrane layer. At least one electrically insulating material is directly or indirectly deposited onto the at least one membrane layer and the at least one first electrically conductive material, and at least one second electrically conductive material is deposited directly or indirectly onto the electrically insulating material. An associated sensor is also disclosed.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Inventors: Karl-Heinz Koelker, Thilo Reschke, Sebastian Kuebler, David Kaspar Siebel
  • Patent number: 10422765
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in vivo conditions, where the systems includes an electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. Methods of making and using the system also are disclosed.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: September 24, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
  • Publication number: 20190254574
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 10349878
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: July 16, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 10330627
    Abstract: Biosensors and biosensor systems are disclosed that have manganese (III) oxide (Mn2O3)-based electrodes that can attenuate interference of a detection signal resulting from an analyte-relevant reaction caused by undesired reaction of interferents in a sample. Methods are also disclosed for making and using the same.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: June 25, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Karl-Heinz Koelker, Arnulf Staib
  • Publication number: 20190029577
    Abstract: Disclosed is an analyte measuring patch for invasive measuring a concentration of an analyte, in particular glucose. The analyte measuring patch includes a sensor with a working electrode (101), a counter electrode (103) and a reference electrode 102). The patch further includes an electronics unit with a microcontroller (1200) and a current measurement unit. The microcontroller (1200) includes a control output (DAC), a first analogue input (ADC-1) and a second analogue input (ADC-2). The control output (DAC) is operatively coupled with a control electrode, the control electrode being either of the working electrode or (101) or the counter electrode (103). The first analogue input (ADC-2) is operatively coupled with a measurement electrode via the current measurement unit, the measurement electrode being either of the working electrode (101) or the counter electrode (103). The second analogue input (ADC-1) is operatively coupled with the reference electrode (102).
    Type: Application
    Filed: March 9, 2017
    Publication date: January 31, 2019
    Applicant: Roche Diabetes Care, Inc.
    Inventors: Karl-Heinz Koelker, Frederic Wehowski
  • Publication number: 20170367628
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 28, 2017
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 9757060
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: September 12, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 9709520
    Abstract: The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, between an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: July 18, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Gregor Ocvirk, Karl-Heinz Kölker
  • Publication number: 20160077036
    Abstract: The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, between an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Inventors: Gregor Ocvirk, Karl-Heinz Kölker
  • Patent number: 9220451
    Abstract: The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, beween an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: December 29, 2015
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Gregor Ocvirk, Karl-Heinz Kölker
  • Publication number: 20150320345
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Application
    Filed: July 20, 2015
    Publication date: November 12, 2015
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Patent number: 9084570
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: July 21, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger
  • Publication number: 20150005605
    Abstract: An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. The electrode system also can include a spacer membrane that includes a hydrophilic copolymer of acrylic and/or methacrylic monomers.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
  • Publication number: 20140251826
    Abstract: Biosensors and biosensor systems are disclosed that have manganese (III) oxide (Mn2O3)-based electrodes that can attenuate interference of a detection signal resulting from an analyte-relevant reaction caused by undesired reaction of interferents in a sample. Methods are also disclosed for making and using the same.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Karl-Heinz Koelker, Arnulf Staib
  • Patent number: 8821413
    Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: September 2, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck
  • Publication number: 20140018653
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in vivo conditions, where the systems includes an electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. Methods of making and using the system also are disclosed.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
  • Publication number: 20130253293
    Abstract: The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, beween an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.
    Type: Application
    Filed: September 10, 2012
    Publication date: September 26, 2013
    Inventors: Gregor Ocvirk, Karl-Heinz Kölker
  • Patent number: 8388552
    Abstract: A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: March 5, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Carlo Effenhauser, Heinz-Michael Hein, Karl-Heinz Koelker, Frank Deck
  • Publication number: 20120088993
    Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Inventors: Harvey Buck, Georgeta Lica, Karl-Heinz Koelker, Ewald Rieger