Patents by Inventor Karl-Heinz LEHR

Karl-Heinz LEHR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them
    Patent number: 8586612
    Abstract: The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of formula I, in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of formula I are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: November 19, 2013
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Stephanie Hachtel, Heinrich Christian Englert, Uwe Gerlach, Heinz Goegelein, Holger Heitsch, Karl-Heinz Lehr, Stefania Pfeiffer-Marek
  • Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them
    Publication number: 20080033016
    Abstract: The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of formula I, in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of formula I are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
    Type: Application
    Filed: June 12, 2007
    Publication date: February 7, 2008
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Stephanie HACHTEL, Heinrich ENGLERT, Uwe GERLACH, Heinz GOEGELEIN, Holger HEITSCH, Karl-Heinz LEHR, Stefania PFEIFFER-MAREK