Patents by Inventor Karl-Heinz Schlemmer

Karl-Heinz Schlemmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE
    Publication number: 20180263981
    Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: May 16, 2018
    Publication date: September 20, 2018
    Applicant: ADVERIO PHARMA GMBH
    Inventors: Markus FOLLMANN, Johannes-Peter STASCH, Gorden REDLICH, Jens ACKERSTAFF, Nils GRIEBENOW, Walter KROH, Andreas KNORR, Eva-Maria BECKER, Frank WUNDER, Volkhart Min-Jian LI, Elke HARTMANN, Joachim MITTENDORF, Karl-Heinz SCHLEMMER, Rolf JAUTELAT, Donald BIERER
  • Substituted oxopyridine derivatives
    Patent number: 10077265
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: September 18, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Alexander Hillisch, Julia Straβburger, Stefan Heitmeier, Martina Victoria Schmidt, Karl-Heinz Schlemmer, Adrian Tersteegen, Anja Buchmüller, Christoph Gerdes, Martina Schäfer, Henrik Teller, Eloisa Jiménez Núnez, Hartmut Schirok, Jürgen Klar, Mario Lobell
  • Substituted oxopyridine derivatives
    Patent number: 10071995
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: September 11, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Eloisa Jimenez Núnez, Karl-Heinz Schlemmer, Adrian Tersteegen, Henrik Teller, Alexander Hillisch, Stefan Heitmeier, Martina Victoria Schmidt, Jan Stampfuß
  • Branched 3-phenylpropionic acid derivatives and their use
    Patent number: 10023528
    Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: July 17, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Michael Hahn, Thomas Lampe, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Volkhart Min-Jian Li, Eva-Maria Becker-Pelster, Friederike Stoll, Andreas Knorr, Elisabeth Woltering
  • Substituted 5-flouro-1H-pyrazolopyridines and their use
    Patent number: 9993476
    Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: June 12, 2018
    Assignee: ADVERIO PHARMA GMBH
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Walter Kroh, Andreas Knorr, Eva-Maria Becker, Frank Wunder, Volkhart Min-Jian Li, Elke Hartmann, Joachim Mittendorf, Karl-Heinz Schlemmer, Rolf Jautelat, Donald Bierer
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES
    Publication number: 20180127401
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 22, 2015
    Publication date: May 10, 2018
    Inventors: Susanne RÖHRIG, Eloisa JIMÉNEZ NÚNEZ, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Henrik TELLER, Alexander HILLISCH, Stefan HEITMEIER, Martina Victoria SCHMIDT, Jan STAMPFUß
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS
    Publication number: 20180086742
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: October 17, 2017
    Publication date: March 29, 2018
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRASSBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Anja BUCHMÜLLER, Christoph GERDES, Martina SCHÄFER, Tom KINZEL, Henrik TELLER, Harmut SCHIROK, Jürgen KLAR, Eloisa Jimenez NUNEZ
  • Substituted oxopyridine derivatives and use thereof as factor XIa/plasma
    Patent number: 9918969
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: March 20, 2018
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Susanne Röhrig, Alexander Hillisch, Julia Straβburger, Stefan Heitmeier, Martina Victoria Schmidt, Karl-Heinz Schlemmer, Anja Buchmüller, Christoph Gerdes, Henrik Teller, Martina Schäfer, Adrian Tersteegen
  • PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE
    Publication number: 20170334917
    Abstract: The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 23, 2017
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Manuel ELLERMANN, Gaelle VALOT, Yolanda CANCHO GRANDE, Jorma HAßFELD, Tom KINZEL, Johannes KÖBBERLING, Kristin BEYER, Susanne RÖHRIG, Michael SPERZEL, Jan STAMPFUß, Imke MEYER, Maria KÖLLNBERGER, Nils BURKHARDT, Karl-Heinz SCHLEMMER, Christian STEGMANN, Joachim SCHUHMACHER, Matthias WERNER, Jörg HEIERMANN, Willem Jan HENGEVELD
  • Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
    Patent number: 9822102
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 4, 2016
    Date of Patent: November 21, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Alexander Hillisch, Julia Strassburger, Stefan Heitmeier, Martina Victoria Schmidt, Karl-Heinz Schlemmer, Adrian Tersteegen, Anja Buchmüller, Christoph Gerdes, Martina Schäfer, Tom Kinzel, Henrik Teller, Hartmut Schirok, Jürgen Klar, Eloisa Jimenez Nunez
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES
    Publication number: 20170298052
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 22, 2015
    Publication date: October 19, 2017
    Inventors: Susanne RÖHRIG, Eloisa JIMENEZ NUNEZ, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Henrik TELLER, Alexander HILLISCH, Stefan HEITMEIER, Martina Victoria SCHMIDT, Jan STAMPFUß
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES
    Publication number: 20170291892
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 22, 2015
    Publication date: October 12, 2017
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne RÖHRIG, Eloisa JIMENEZ-NUNEZ, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Henrik TELLER, Alexander HILLISCH, Stefan HEITMEIER, Martina Victoria SCHMIDT, Jens ACKERSTAFF, Jan STAMPFUß
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES
    Publication number: 20170283412
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 22, 2015
    Publication date: October 5, 2017
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRAßBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Anja BUCHMÜLLER, Christoph GERDES, Martina SCHÄFER, Henrik TELLER, Eloisa JIMÉNEZ NÚNEZ, Hartmut SCHIROK, Jürgen KLAR, Mario LOBELL
  • FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES
    Publication number: 20170275282
    Abstract: The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 22, 2015
    Publication date: September 28, 2017
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Martina SCHÄFER, Henrik TELLER, Eloisa JIMÈNEZ NÙNEZ
  • SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE
    Publication number: 20170273977
    Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: November 10, 2016
    Publication date: September 28, 2017
    Applicant: ADVERIO PHARMA GMBH
    Inventors: Markus FOLLMANN, Johannes-Peter STASCH, Gorden REDLICH, Jens ACKERSTAFF, Nils GRIEBENOW, Walter KROH, Andreas KNORR, Eva-Maria BECKER, Frank WUNDER, Volkhart Min-Jian LI, Elke HARTMANN, Joachim MITTENDORF, Karl-Heinz SCHLEMMER, Rolf JAUTELAT, Donald BIERER
  • Substituted oxopyridine derivatives
    Patent number: 9765070
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: September 19, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Alexander Hillisch, Julia Strassburger, Stefan Heitmeier, Martina Victoria Schmidt, Karl-Heinz Schlemmer, Adrian Tersteegen, Anja Buchmüller, Christoph Gerdes, Martina Schäfer, Henrik Teller, Eloisa Jimenez Nunez, Hartmut Schirok, Jürgen Klar
  • (AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AND THEIR USE
    Publication number: 20170239251
    Abstract: The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
    Type: Application
    Filed: January 26, 2017
    Publication date: August 24, 2017
    Inventors: Jorma HAßFELD, Tom KINZEL, Johannes KÖBBERLING, Yolanda CANCHO-GRANDE, Kristin BEYER, Susanne RÖHRIG, Maria KÖLLNBERGER, Michael SPERZEL, Nils BURKHARDT, Karl-Heinz SCHLEMMER, Christian STEGMANN, Joachim SCHUHMACHER, Matthias WERNER, Manuel ELLERMANN
  • (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
    Patent number: 9598417
    Abstract: The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 21, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Jorma Haβfeld, Tom Kinzel, Johannes Köbberling, Yolanda Cancho Grande, Kristin Beyer, Susanne Röhrig, Maria Köllnberger, Michael Sperzel, Nils Burkhardt, Karl-Heinz Schlemmer, Christian Stegmann, Joachim Schuhmacher, Matthias Werner, Manuel Ellermann
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF AS FACTOR XIA/PLASMA
    Publication number: 20170035739
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: October 24, 2016
    Publication date: February 9, 2017
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRASSBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Anja BUCHMÜLLER, Christoph GERDES, Henrik TELLER, Martina SCHÄFER, Adrian TERSTEEGEN
  • SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS
    Publication number: 20160368903
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Application
    Filed: September 4, 2016
    Publication date: December 22, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Susanne RÖHRIG, Alexander HILLISCH, Julia STRASSBURGER, Stefan HEITMEIER, Martina Victoria SCHMIDT, Karl-Heinz SCHLEMMER, Adrian TERSTEEGEN, Anja BUCHMÜLLER, Christoph GERDES, Martina SCHÄFER, Tom KINZEL, Henrik TELLER, Hartmut SCHIROK, Jürgen KLAR, Eloisa Jimenez NUNEZ