Patents by Inventor Karl Heller

Karl Heller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions
    Publication number: 20050214324
    Abstract: The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of primary cells may be one step in a method for the amplification of viruses, such as poxviruses. According to this latter method the primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The cells are then infected with the virus and the infected cells are cultivated in serum free medium until progeny virus is produced.
    Type: Application
    Filed: March 3, 2005
    Publication date: September 29, 2005
    Applicant: BAVARIAN NORDIC A/S
    Inventors: Ingmar Rathe, Eva Felder, Karl Heller
  • Method for virus propagation
    Patent number: 6924137
    Abstract: The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased virus propagation at the decreased temperature.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: August 2, 2005
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Karl Heller, Ingmar Räthe
  • Poxvirus containing formulations and process for preparing stable poxvirus containing compositions
    Publication number: 20050019349
    Abstract: The present invention relates to a formulation, in particular an aqueous formulation comprising (i) a poxvirus of one of the genera orthopoxvirus, avipoxvirus, parapoxvirus, capripoxvirus and suipoxvirus, (ii) a disaccharide, (iii) a pharmaceutically acceptable polymer and optionally (iv) a buffer. The aqueous formulation is particularly suitable for freeze drying processes resulting in a stable, freeze-dried, poxvirus containing composition. The invention further concerns a method for preparing a freeze-dried, pox virus containing composition and the thus obtained product.
    Type: Application
    Filed: November 28, 2002
    Publication date: January 27, 2005
    Inventors: Paul Howley, Karl Heller, Ingmar Rathe
  • Method for the recovery and purification of poxviruses from infected cells
    Publication number: 20040265986
    Abstract: The present invention relates to a method for the recovery of poxviruses, in particular modified Vaccinia virus Ankara (MVA), from infected cells. According to the present invention the virus-infected cells are subjected to a high-pressure homogenization to obtain a virus containing homogenate. The virus containing homogenate can be subjected to at least one purification step to obtain apoxvirus-enriched fraction. The invention further relates to the virus containing fraction and the virus containing homogenate obtained by the method according to the present invention.
    Type: Application
    Filed: May 10, 2004
    Publication date: December 30, 2004
    Inventors: Karl Heller, Jutta Kramer
  • Method for virus propagation
    Publication number: 20040234950
    Abstract: The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased virus propagation at the decreased temperature.
    Type: Application
    Filed: February 17, 2004
    Publication date: November 25, 2004
    Inventors: Paul Howley, Karl Heller, Ingmar Rathe