Abstract: The present invention provides a compound of Formula (I), or a solvate, a tautomer, a stereoisomer or a salt thereof, for use in the treatment of cancer, in particular prostate cancer. These compounds are of use in cancer immunotherapy and may be used in combination therapies with immune checkpoint inhibitors and tumour microenvironment modulators. The invention also provides compositions comprising the compounds of the invention, as well as the use of compounds of the invention as STAT3 inhibitors.

Abstract: The present invention provides a method for the treatment of a tumour in a subject, said method comprising administering (i) an autologous immature dendritic cell, or a precursor thereof, and (ii) an immune cell checkpoint inhibitor to said subject subsequent to the at least partial ablation of said tumour in said subject, wherein the administration of said autologous immature dendritic cells, or a precursor thereof, and said immune cell checkpoint inhibitor is local to the site of the ablated tumour or part thereof.

Abstract: The present disclosure is generally directed to systems and methods for executing various types of maintenance operations upon various types of printers. The maintenance operations can include preemptive actions that are taken upon a printer that is being operated in a certain environment, the preemptive actions based on evaluating operational statistics associated with a set of similar printers operated in a similar environment. The operational statistics, which are automatically accumulated over a period of time for various printers under various operating conditions, can be implemented in various ways, such as in the form of behavioral models and/or predictive models. In some embodiments, the behavioral models and/or predictive models indicate an expected-time-to-failure of a component when a printer is operated in a certain environment.

Abstract: The present disclosure is generally directed to systems and methods for executing various types of maintenance operations upon various types of printers. The maintenance operations can include preemptive actions that are taken upon a printer that is being operated in a certain environment, the preemptive actions based on evaluating operational statistics associated with a set of similar printers operated in a similar environment. The operational statistics, which are automatically accumulated over a period of time for various printers under various operating conditions, can be implemented in various ways, such as in the form of behavioral models and/or predictive models. In some embodiments, the behavioral models and/or predictive models indicate an expected-time-to-failure of a component when a printer is operated in a certain environment.

Abstract: Systems and methods for configuring the settings of a peripheral device are provided. In one implementation, a method includes a step of determining when the peripheral device is powered up and in communication with a host device. The method further includes the step of reading configuration settings associated with an operating system of the host device when the peripheral device is determined to be powered up and in communication with the host device. Also, the method includes communicating the configuration settings associated with the operating system of the host device to the peripheral device for configuring the settings of the peripheral device.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A label printing device and method include a proportional-integral-derivative controller and a variable speed printer motor. The variable speed printer motor is connected to the proportion-integral-derivative controller, and has an automatically optimized printing speed determined by a print duration history of one or more previously completed print jobs.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A label printing device and method include a proportional-integral-derivative controller and a variable speed printer motor. The variable speed printer motor is connected to the proportion-integral-derivative controller, and has an automatically optimized printing speed determined by a print duration history of one or more previously completed print jobs.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A method for evaluating an output pattern printed on a medium is described. A reference pattern is stored. The output pattern is printed on the medium based correspondingly on the stored reference pattern. A scan based instance of the output pattern is rendered, which has a set of features at least corresponding to the printed output pattern and zero or more features additional thereto. A difference image, having the zero or more features of the rendered scan instance, is computed based on a comparison of the rendered scan instance to the stored reference pattern. Upon the zero or more features including at least one feature, the computed difference image is evaluated in relation to a proximity of at least one feature to locations pixels of the reference pattern.

Abstract: A method for processing a semiconductor device, the method including; providing a first semiconductor layer including first transistors; forming interconnection layers overlying the transistors, where the interconnection layers include copper or aluminum; forming a shielding heat conducting layer overlaying the interconnection layers; forming an isolation layer overlaying the shielding heat conducting layer; forming a second semiconductor layer overlying the isolation layer, and processing the second semiconductor layer at a temperature greater than about 400° C., where the interconnection layers are kept at a temperature below about 400° C.

Abstract: Hybrid vehicles and other vehicles with one or more torque producing devices operate more effectively with proper resolution of torque requests. In one aspect of the present invention, a plurality of vehicle force and torque requests are resolved at different levels depending on the vehicle architecture. In another aspect of the present invention, torque requests are resolved into base requests and fast requests depending upon response times of torque devices satisfying these requests.

Abstract: A thernopneumatic valve comprises a fluid channel plate defining a fluid port. A diaphragm plate is attached to the fluid channel plate. The diaphragm plate includes a displaceable diaphragm to selectively obstruct the fluid port of the fluid channel plate. A thermal isolating heater is connected to the diaphragm plate. The thermal isolating heater includes a thermal isolating heater body with a heating surface, a perimeter wall defining an extended axial cavity to confine a thermopneumatic working fluid that is used to control the position of the displaceable diaphragm, and a diaphragm obstruction structure to limit the motion of the displaceable diaphragm into the extended axial cavity.

Abstract: A pressure testing device for detecting leaks in shipping vessels such as tank cars, delivery pipes, and tanker trucks. A hand-operated pump provides a source of pressure, with the pump having a hand plunger reciprocating within a pump body with handles at each end. At the end opposite the plunger handle there is a bifurcated fitting with a one-way valve in each of its two branches, with a first branch permitting only pump intake, and the second branch permitting only pump discharge. Both branches are fitted with quick-disconnect couplings which mate with a detachable flexible hose terminating in a test closure or pressure fitting having a shutoff valve and a pressure gauge. In use, the operator attaches the test closure to the vessel or pipe to be tested, attaches the hose to the proper coupling for delivery of the positive or negative pressure differential as desired, and operates the reciprocating hand plunger until the desired pressure differential is indicated on the gauge.

Abstract: A vulcanization method and press in which at time-spaced intervals of 1 to 40 seconds, temperature measurements representing increments of heat supplied to the vulcanizable body are taken of a medium used for vulcanization. A summation of the measurements continuously during the vulcanization process represents the heat supplied to the body and when the summed heat quantity equals the total heat quantity previously determined to be necessary for complete vulcanization, the process is terminated.