Patents by Inventor Karl J. Simin

Karl J. Simin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-tumor properties of Dickkopf 3b
    Patent number: 11421008
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: August 23, 2022
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Deborah M. Leonard, Karl J. Simin
  • Anti-cancer and anti-inflammatory therapeutics and methods thereof
    Patent number: 11116851
    Abstract: The invention relates to the discovery of a vital new component of the Wnt pathway that regulates trafficking of ?-catenin to the cell nucleus and novel therapeutic approaches to cancer treatment. Disclosed herein is a previously unknown, essential component of the Wnt/?-catenin signaling pathway that governs the quantity of ?-catenin delivered to the cell nucleus. This intracellular inhibitor of ?-catenin signaling (IBS) is transcribed from a second transcriptional start site adjacent to exon 3 of the Dkk3 gene and is required for early mouse development. IBS captures ?-catenin destined for the nucleus in a complex with ?-TrCP that is bound to the actin cytoskeleton and unavailable for nuclear translocation.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: September 14, 2021
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Karl J. Simin, Deborah M. Leonard
  • Anti-Tumor Properties of Dickkopf 3b
    Publication number: 20200109180
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Application
    Filed: September 6, 2019
    Publication date: April 9, 2020
    Inventors: Jack L. Leonard, Deborah M. Leonard, Karl J. Simin
  • Anti-tumor properties of Dickkopf 3b
    Patent number: 10407478
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: September 10, 2019
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Deborah M. Leonard, Karl J. Simin
  • ANTI-CANCER AND ANTI-INFLAMMATORY THERAPEUTICS AND METHODS THEREOF
    Publication number: 20180272001
    Abstract: The invention relates to the discovery of a vital new component of the Wnt pathway that regulates trafficking of ?-catenin to the cell nucleus and novel therapeutic approaches to cancer treatment. Disclosed herein is a previously unknown, essential component of the Wnt/?-catenin signaling pathway that governs the quantity of ?-catenin delivered to the cell nucleus. This intracellular inhibitor of ?-catenin signaling (IBS) is transcribed from a second transcriptional start site adjacent to exon 3 of the Dkk3 gene and is required for early mouse development. IBS captures ?-catenin destined for the nucleus in a complex with ?-TrCP that is bound to the actin cytoskeleton and unavailable for nuclear translocation.
    Type: Application
    Filed: October 18, 2016
    Publication date: September 27, 2018
    Inventors: Jack L. Leonard, Karl J. Simin, Deborah M. Leonard
  • Anti-tumor properties of Dickkopf 3b
    Patent number: 9856301
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: January 2, 2018
    Assignee: University of Massachusetts
    Inventors: Jack L. Leonard, Deborah M. Leonard, Karl J. Simin
  • ANTI-TUMOR PROPERTIES OF DICKKOPF 3b
    Publication number: 20160326225
    Abstract: The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
    Type: Application
    Filed: May 17, 2016
    Publication date: November 10, 2016
    Inventors: Jack L. LEONARD, Deborah M. LEONARD, Karl J. Simin