Patents by Inventor Karl Jacobs
Karl Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11945863Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.Type: GrantFiled: December 1, 2017Date of Patent: April 2, 2024Assignee: Friedrich-Alexander-Universität Erlangen-NürnbergInventors: Georg H. Fey, Todd Braciak, Claudia C. Roskopf, Ingo Schubert, Karl-Peter Hopfner, Nadja Fenn, Sarah Wildenhain, Uwe Jacob
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Patent number: 11919866Abstract: A process for producing a cyclic alkylene urea product of Formula I: in which a compound of Formula II and/or Formula III is contacted in a reaction zone with a compound of Formula IV and/or Formula V and in the presence of one or more carbonyl delivering compounds; wherein the compound of Formula II and/or the compound of Formula III are added to a reaction zone comprising compound of Formula IV and/or compound of Formula (V) continuously or semi-continuously over a period of time, or in two or more batches.Type: GrantFiled: August 7, 2018Date of Patent: March 5, 2024Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.Inventors: Antoon Jacob Berend Ten Kate, Karl Fredrik Lake, Michiel Jozef Thomas Raaijmakers, Rolf Krister Edvinsson, Jenny Valborg Therese Adrian Meredith, Rens Veneman, Hendrik Van Dam, Eike Nicolas Kantzer, Ina Ehlers, Slavisa Jovic
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Publication number: 20230307110Abstract: Clinical supply packs may be provided with electronic paper labels displaying information updated based on internal sensors and inputs of the clinical supply pack or communications with an external communication device, where the communication device is in communication with a central system. Display information may include multilingual data provided to supply packs after they are sealed for distribution, and may include updated dosing regimens and clinical trial updates provided after dispensing.Type: ApplicationFiled: August 27, 2021Publication date: September 28, 2023Inventors: Roger LAUWERS, Karl JACOBS
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Publication number: 20210046563Abstract: The invention relates to a saw blade 1 comprising a circular disc 2 having curved recesses 3 around its circumference. Each recess has a notch 5; a series of teeth 4 fitted within the recesses. Each tooth has a cutting bit 7 and a shank 6 separate from one another until installed. Each cutting bit 7 has a base with an aperture 14 therein; and a plurality of fixing members 13, The arrangement is characterised in that for each tooth 4, one of the fixing members 13 is engaged with the aperture 14 and extends from the cutting bit 7 to also engage a corresponding one of the notches 5 to restrain the tooth 4 from becoming dislodged from the recess 3 it is in.Type: ApplicationFiled: August 14, 2020Publication date: February 18, 2021Inventor: Karl Jacob PETERSON
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Publication number: 20210023733Abstract: Referring to FIG. 1), a sawmill has a pair of spaced end frames (1), (2), (4), a support beam (17) spanning the end frames and a saw carriage (56) moveable along the beam to carry a saw towards one end frame and then towards the other end frame. Each end frame has a ground engaging cross bar (1), a movable horizontal member (2) mounted on the cross bar (1) and an upright post (4). For each end frame the horizontal member (2) can run along the cross bar (1) to move the post (4) and consequently the beam (17) in adjustable increments towards one side of the sawmill and then towards the other side of the sawmill. The posts (4) support the beam (17) in a vertically adjustable elevated disposition.Type: ApplicationFiled: September 28, 2020Publication date: January 28, 2021Inventors: CARL JAMES PETERSON, KARL JACOB PETERSON
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Patent number: 10293511Abstract: A sawmill 1 has an operator end 6, a pair of end frames 2, a track 3 elevated by and extending from at least one end frame to the other, a carriage moveable 4 to carry a saw 5 along at least part of the track, flip elements able to move the saw from a horizontal cutting orientation to a vertical cutting orientation, and a relocatable stopper 13 associated with the track. The carriage 4 can be driven away from the operator end 16 with the saw 5 in the horizontal cutting orientation to contact the stopper 13 when the carriage, this resulting in the flip elements automatically moving the saw 4 into the vertical cutting orientation.Type: GrantFiled: October 13, 2015Date of Patent: May 21, 2019Inventor: Karl Jacob Peterson
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Publication number: 20190063270Abstract: A camshaft phaser includes an input member; an output member defining an advance chamber and a retard chamber with the input member; a supply passage; a vent passage; and a valve spool within the output member which is moveable between a first and second position. The first position prevents communication between the advance chamber and the vent passage, prevents communication between the retard chamber and the vent passage, and allows oil to flow from one of the advance chamber and the retard chamber to the other of the advance chamber and the retard chamber. The second position provides communication between the vent passage and one of the advance chamber and the retard chamber, prevents communication between the vent passage and the other of the advance chamber and the retard chamber, and provides communication between the supply passage and the other of the advance chamber and the retard chamber.Type: ApplicationFiled: June 26, 2018Publication date: February 28, 2019Inventors: Karl Jacob Haltiner, JR., Devin C. Prescott
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Patent number: 9437880Abstract: A method of manufacturing a solid oxide fuel cell stack having an electrically conductive interconnect, including the steps of: (a) providing a first fuel cell and a second fuel cell, (b) providing a substrate having an iron-chromium alloy, (c) depositing a layer of metallic cobalt over a portion of substrate surface, (d) subjecting the layer of metallic cobalt to reducing conditions, (e) then exposing the remaining portion of the layer of metallic cobalt to oxidizing conditions for a predetermined time and temperature, such that the surface portion of the layer of metallic cobalt is oxidized to cobalt oxide, thereby forming the electrically conductive interconnect having a layer of metallic cobalt sandwiched between a surface layer of cobalt oxide and the layer of cobalt-iron-chromium alloy, and (f) sandwiching the substrate between the first and second fuel cells.Type: GrantFiled: September 20, 2012Date of Patent: September 6, 2016Assignees: Delphi Technologies, Inc., Battelle Memorial InstituteInventors: Subhasish Mukerjee, Karl Jacob Haltiner, Jr., Kerry D. Meinhardt, Jin Yong Kim, Eric S. Mast, Vincent L. Sprenkle
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Publication number: 20160214270Abstract: A sawmill 1 has an operator end 6, a pair of end frames 2, a track 3 elevated by and extending from at least one end frame to the other, a carriage moveable 4 to carry a saw 5 along at least part of the track, flip elements able to move the saw from a horizontal cutting orientation to a vertical cutting orientation, and a relocatable stopper 13 associated with the track. The carriage 4 can be driven away from the operator end 16 with the saw 5 in the horizontal cutting orientation to contact the stopper 13 when the carriage, this resulting in the flip elements automatically moving the saw 4 into the vertical cutting orientation.Type: ApplicationFiled: October 13, 2015Publication date: July 28, 2016Inventor: Karl Jacob PETERSON
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Publication number: 20150303490Abstract: A method of manufacturing a solid oxide fuel cell stack having an electrically conductive interconnect, including the steps of: (a) providing a first fuel cell and a second fuel cell, (b) providing a substrate having an iron-chromium alloy, (c) depositing a layer of metallic cobalt over a portion of substrate surface, (d) subjecting the layer of metallic cobalt to reducing conditions, (e) then exposing the remaining portion of the layer of metallic cobalt to oxidizing conditions for a predetermined time and temperature, such that the surface portion of the layer of metallic cobalt is oxidized to cobalt oxide, thereby forming the electrically conductive interconnect having a layer of metallic cobalt sandwiched between a surface layer of cobalt oxide and the layer of cobalt-iron-chromium alloy, and (f) sandwiching the substrate between the first and second fuel cells.Type: ApplicationFiled: September 20, 2012Publication date: October 22, 2015Applicant: DELPHI TECHNOLOGIES, INC.Inventors: SUBHASISH MUKERJEE, KARL JACOB HALTINER, Jr., KERRY D. MEINHARDT, JIN YONG KIM, ERIC S. MAST, VINCENT L. SPRENKLE
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Patent number: 9153834Abstract: A fuel cell stack assembly includes a fuel cell stack wherein a plurality of fuel cell cassettes is coupled together by a joining material. A spring strap is coupled to the fuel cell stack in a manner effective to apply a first compressive force to the fuel cell stack. A first load distribution plate is located intermediate the fuel cell stack and the spring strap. The first load distribution plate is configured to distribute the first compressive force over the fuel cell stack in a manner effective to normalize the first compressive force on the joining material. A diaphragm is configured to define a cavity and is configured to apply a second compressive force to the fuel cell stack dependent on a cavity pressure of oxidant within the cavity. The cavity pressure is dependent upon an oxidant pressure of oxidant provided to the fuel cell stack.Type: GrantFiled: November 21, 2011Date of Patent: October 6, 2015Assignee: Delphi Technologies, Inc.Inventors: Karl Jacob Haltiner, Jr., Charles Joseph Badura
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Patent number: 8970900Abstract: Systems and methods for providing automated layouts and designs for recording text and images on any of a plurality of disparate three-dimensional objects. Server-based processing engine for automatically imposing designs and text onto consumer electronic devices and method for delivering the same to consumers.Type: GrantFiled: October 14, 2013Date of Patent: March 3, 2015Assignee: Coveroo, Inc.Inventors: Karl Jacob, Mark Halstead
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Publication number: 20140230625Abstract: Referring to FIG. (1), a sawmill has a pair of spaced end frames (1), (2), (4), a support beam (17) spanning the end frames and a saw carriage (56) moveable along the beam to carry a saw towards one end frame and then towards the other end frame. Each end frame has a ground engaging cross bar (1), a movable horizontal member (2) mounted on the cross bar (1) and an upright post (4). For each end frame the horizontal member (2) can run along the cross bar (1) to move the post (4) and consequently the beam (17) in adjustable increments towards one side of the sawmill and then towards the other side of the sawmill. The posts (4) support the beam (17) in a vertically adjustable elevated disposition.Type: ApplicationFiled: August 22, 2008Publication date: August 21, 2014Inventors: Carl James Peterson, Karl Jacob Peterson
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Publication number: 20140049787Abstract: Systems and methods for providing automated layouts and designs for recording text and images on any of a plurality of disparate three-dimensional objects. Server-based processing engine for automatically imposing designs and text onto consumer electronic devices and method for delivering the same to consumers.Type: ApplicationFiled: October 14, 2013Publication date: February 20, 2014Inventors: Karl JACOB, Mark HALSTEAD
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Publication number: 20130302709Abstract: A method is provided for adding sulfur to a solid oxide fuel cell (SOFC) stack having a Ni—YSZ anode to prolong the life of the SOFC stack. The method includes the steps of providing a reformate stream essentially free of sulfur compounds, feeding the reformate stream to the SOFC stack, and adding a predetermined amount of a sulfur compound into the reformate stream upstream of the SOFC stack. The predetermined amount of the sulfur compound is effective to prolong the life of the Ni—YSZ anode by retarding the formation of carbon onto the Ni—YSZ anode and the coarsening of the granular microstructure of the Ni—YSZ anode, while minimizing the degradation of power output of the SOFC stack within a predetermined limit.Type: ApplicationFiled: July 10, 2013Publication date: November 14, 2013Inventors: SUBHASISH MUKERJEE, KARL JACOB HALTINER,, JR., JEFFREY G. WIESSMAN
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Patent number: 8559052Abstract: Systems and methods for providing automated layouts and designs for recording text and images on any of a plurality of disparate three-dimensional objects. Server-based processing engine for automatically imposing designs and text onto consumer electronic devices and method for delivering the same to consumers.Type: GrantFiled: October 22, 2010Date of Patent: October 15, 2013Assignee: Coveroo, Inc.Inventors: Karl Jacob, Mark Halstead
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Publication number: 20130196253Abstract: A solid oxide fuel cell (SOFC) stack having a glass seal sandwiched between the sealing surfaces of adjacent cassettes, in which at least one cassette includes means for interlocking the glass seal onto the sealing surface of the cassette for improved adhesion and durability of the glass seal. The at least one cassette includes a plurality of perforations configured to receive and lock onto a portion of the glass seal. At least one of the perforations includes a through-hole having an exterior opening on the sealing surface and an interior opening on the interior surface of the cassette. A portion of the glass seal is received in the perforation forming a glass column in the through-hole and a flared glass end on the interior surface surrounding the interior opening. The flared glass end cooperates with the glass column to interlock the glass seal onto the cassette's sealing surface.Type: ApplicationFiled: January 31, 2012Publication date: August 1, 2013Applicant: DELPHI TECHNOLOGIES, INC.Inventors: ANTHONY J. DE ROSE, SUBHASISH MUKERJEE, RAY BASSETT, KARL JACOB HALTINER, JR.
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Publication number: 20130130148Abstract: A fuel cell stack assembly includes a fuel cell stack wherein a plurality of fuel cell cassettes is coupled together by a joining material. A spring strap is coupled to the fuel cell stack in a manner effective to apply a first compressive force to the fuel cell stack. A first load distribution plate is located intermediate the fuel cell stack and the spring strap. The first load distribution plate is configured to distribute the first compressive force over the fuel cell stack in a manner effective to normalize the first compressive force on the joining material. A diaphragm is configured to define a cavity and is configured to apply a second compressive force to the fuel cell stack dependent on a cavity pressure of oxidant within the cavity. The cavity pressure is dependent upon an oxidant pressure of oxidant provided to the fuel cell stack.Type: ApplicationFiled: November 21, 2011Publication date: May 23, 2013Applicant: DELPHI TECHNOLOGIES, INC.Inventors: KARL Jacob HALTINER, JR., CHARLES Joseph BADURA
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Patent number: 8420278Abstract: A solid oxide fuel cell stack having a plurality of cassettes and a glass composite seal disposed between the sealing surfaces of adjacent cassettes, thereby joining the cassettes and providing a hermetic seal therebetween. The glass composite seal includes an alkaline earth aluminosilicate (AEAS) glass disposed about a viscous glass such that the AEAS glass retains the viscous glass in a predetermined position between the first and second sealing surfaces. The AEAS glass provides geometric stability to the glass composite seal to maintain the proper distance between the adjacent cassettes while the viscous glass provides for a compliant and self-healing seal. The glass composite seal may include fibers, powders, and/or beads of zirconium oxide, aluminum oxide, yttria-stabilized zirconia (YSZ), or mixtures thereof, to enhance the desirable properties of the glass composite seal.Type: GrantFiled: December 30, 2010Date of Patent: April 16, 2013Assignee: Delphi Technologies, Inc.Inventors: Anthony J. De Rose, Subhasish Mukerjee, Karl Jacob Haltiner, Jr.
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Publication number: 20120251906Abstract: A system for adding sulfur to a reformate stream feeding a fuel cell stack, having a sulfur source for providing sulfur to the reformate stream and a metering device in fluid connection with the sulfur source and the reformate stream. The metering device injects sulfur from the sulfur source to the reformate stream at a predetermined rate, thereby providing a conditioned reformate stream to the fuel cell stack. The system provides a conditioned reformate stream having a predetermined sulfur concentration that gives an acceptable balance of minimal drop in initial power with the desired maximum stability of operation over prolonged periods for the fuel cell stack.Type: ApplicationFiled: January 25, 2012Publication date: October 4, 2012Applicant: DELPHI TECHNOLOGIES, INC.Inventors: SUBHASISH MUKERJEE, KARL JACOB HALTINER, JR., JEFFREY G. WEISSMAN