Abstract: Method for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Via the microcatheter, only embolic solution is injected into the vessel. Aspirated fluid representing only a portion of the injected embolic solution present in the vessel is aspirated into the microcatheter to prevent the injected embolic solution present in the vessel from proximally migrating in the vessel. Alternatively, the injected embolic solution is prevented from proximal migration by occluding the vessel with the distal end of the microcatheter.

Abstract: Method and system for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Embolic solution is injected into the vessel. Proximal migration in the vessel of the injected embolic solution is prevented by injecting into the vessel a glucose solution.

Abstract: Cyclic aspiration system including an aspiration catheter and a cyclic aspiration source connected in fluid communication thereto, wherein the cyclic aspiration pressure source produces a cyclic aspiration pressure waveform of intermittently cycling intervals of a vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system further including a non-powered internal structural impediment disposed within the lumen of the aspiration catheter and configured to engage with a clot capturable therein during resulting movement between the clot and the non-powered internal structural impediment while subject to the cyclic aspiration pressure waveform to assist in capture of the clot. The non-powered internal structural impediment may be permanently attached to the aspiration catheter or a separate component or device independently slidable within the lumen of the aspiration catheter.

Abstract: A clot removal assembly for removing a clot from a vessel that includes a delivery catheter, a clot retrieval device, and a valve assembly is presented herein. In some examples, the clot retrieval device can include a cage structure and a shaft, and the cage structure can be configured to pinch a clot. A portion of the shaft extends through the delivery catheter. In some examples, the valve assembly can include a distal valve, a main body portion, a distal body portion, and a moveable head shell. The distal valve can be configured to engage the proximal region of the delivery catheter. In some examples, the distal body portion can include a plurality of grooves, and the moveable head can be configured to ratchet proximally over the plurality of grooves to thereby maintain tension on the shaft.

Abstract: A retrograde blood flow occlusion flushing device includes a first catheter, and a second catheter. The second catheter is axially movable with respect to the first catheter. The second catheter has an inflatable balloon connected to an outer circumferential surface of the second catheter at the distal end of the second catheter. The balloon is movable between a collapsed state and an inflated state. The second catheter has a port in the sidewall between the proximal end of the balloon and the distal end of the balloon. The balloon has at least one port proximate the proximal end of the balloon. In the inflated state, fluid is deliverable through the lumen of the second catheter, through the port in the sidewall of the second catheter to inflate the balloon and at least some of the fluid exits the inflated balloon in the proximal direction through the port in the balloon.

Abstract: A catheter including a distal tip section disposed on or adjacent the distal end of the catheter, the distal tip section being invertible about a transition between a catheter body and the distal tip section between a first configuration and a second configuration. Retracting the distal tip section causes the distal tip section to invert about the transition from the first to the second configuration, the second configuration comprising an expansile tip with an open funnel-like distal mouth comprising a larger diameter than a diameter of the transition.

Abstract: A clot retrieval catheter can have a tailored, highly flexible body section capable of navigating tortuous routes and an expandable tip for local flow restriction/arrest. The body can be a support tube of struts with a plurality of ribs and one or more axial spines. The support tube can also be a tubular section with a pattern of radial slots to increase flexibility while inhibiting kinking and binding. The ribs and spines can have strut widths which vary along the length of the support tube or can have curves with a non-planar cross section. The ribs can be formed such that they can move when subjected to the loads of a thrombectomy procedure. The structure of the support tube can also be a braided or woven pattern of strands. The support tube can also have a polymer jacket or membrane disposed around at least a portion of the structure.

Abstract: A clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable to a diameter larger than the outer sheath through which it is delivered is described herein. The shaft can have a plurality of supporting braids fixed distally to a radiopaque marker band. The tip can have another plurality of supporting braids fixed proximally to the marker band and a decreasing braid angle distally so that the tip can be heat set to an expanded funnel shape. The wires of the tip braids can follow one spiral direction distally and then invert proximally back on themselves to form the other spiral direction of the braid. This inversion of the wires results in atraumatic distal hoops at the distal termination of the braid. Designs can further have spines capable of resisting elongation of the catheter shaft during a procedure.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable to a diameter larger than the outer sheath through which it is delivered. The shaft can have a plurality of supporting braids fixed distally to a radiopaque marker band. The tip can have another plurality of supporting braids fixed proximally to the marker band and a decreasing braid angle distally so that the tip can be heat set to an expanded funnel shape. The wires of the tip braids can follow one spiral direction distally and then invert proximally back on themselves to form the other spiral direction of the braid. This inversion of the wires results in atraumatic distal hoops at the distal termination of the braid. Designs can further have spines capable of resisting elongation of the catheter shaft during a procedure.

Abstract: A navigation tool including a proximal portion, an enlarged portion, a distal portion, and a lumen. The proximal portion, enlarged portion, and distal portion can have a first outer diameter, second outer diameter, and third outer diameter, respectively. The first outer diameter can be smaller than the second outer diameter. The third outer diameter can be smaller than the first outer diameter. The lumen, passing through the proximal portion, enlarged portion, and distal portion, can have an inner diameter smaller than the third outer diameter. The enlarged portion can be configured to not anchor the navigation tool to vasculature within a patient. The distal portion can be configured to navigate the vasculature within the patient aided at least in part by the enlarged portion. At least a portion of the enlarged portion and distal portion can be disposed within vasculature of the patient.

Abstract: A vascular filter device (1) has a support frame (2) and filter elements (4). The filter elements (4) extend from the support frame towards filter element ends forming an on-axis apex (5) at which they are interconnected by a holder (6). The filter elements (4) are biased such that if unconnected the filter element ends are located between the support frame and said central axis when the vascular filter device is unconstrained. The filter element unconnected positions are provided by the filter element shapes and the angles at which they extend from the support frame, and in one example this is achieved by laser cutting tubing and heat setting the material.

Abstract: A balloon guide catheter system including a balloon guide catheter having a catheter shaft that includes: (i) a main lumen; (ii) an inflation lumen; and (iii) an exhaust lumen. The terminating distal end of the inflation lumen and the terminating distal end of the exhaust lumen being in localized fluid communication with one another underneath the balloon while in a non-inflated state. A balloon is disposed about a distal region of an outer surface of the catheter shaft. The exhaust lumen is configured to purge the residual air in a proximal direction and out from a proximal region of the balloon guide catheter.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter with a large bore shaft and a distal braid-supported tip that is expandable to a diameter larger than the outer sheath through which it is delivered.

Abstract: A clot capture catheter that includes an elongate tubular shaft and a distal tip section that extends distally from the elongate tubular shaft. The elongate tubular shaft includes a proximal end, a distal end, a lumen, and a tubular support which includes an inner layer comprising a polymer material disposed within the tubular support and an outer layer comprising an elastomeric material disposed over the tubular support. The distal tip section includes a first layer and a third layer comprising an elastomeric material, and a second layer comprising a polymer material.

Abstract: A vascular filter device (1) has a support frame (2) and filter elements (4). The filter elements (4) extend from the support frame towards filter element ends forming an on-axis apex (5) at which they are interconnected by a holder (6). The filter elements (4) are biased such that if unconnected the filter element ends are located between the support frame and said central axis when the vascular filter device is unconstrained. The filter element unconnected positions are provided by the filter element shapes and the angles at which they extend from the support frame, and in one example this is achieved by laser cutting tubing and heat setting the material.

Abstract: The disclosed technology can include a catheter braid that can comprise a first region, which can comprise a plurality of wire segments arranged in a first weave pattern, and a second region, which can have a plurality of wire segments arranged in a second weave pattern. The first weave pattern can transition to the second weave pattern at a first transitional point, which can be disposed at an intersection of the first region and the second region. The first transitional point can be where at least one wire of the plurality of wires of the first region can be removed from the second region. The catheter braid can comprise a uniform cross section area across a majority of the first region and a majority of the second region.

Abstract: Cyclic aspiration system including an aspiration catheter and a cyclic aspiration source connected in fluid communication thereto, wherein the cyclic aspiration pressure source produces a cyclic aspiration pressure waveform of intermittently cycling intervals of a vacuum pressure below atmospheric pressure and a positive pressure higher than the vacuum pressure. The system further including a non-powered internal structural impediment disposed within the lumen of the aspiration catheter and configured to engage with a clot capturable therein during resulting movement between the clot and the non-powered internal structural impediment while subject to the cyclic aspiration pressure waveform to assist in capture of the clot. The non-powered internal structural impediment may be permanently attached to the aspiration catheter or a separate component or device independently slidable within the lumen of the aspiration catheter.

Abstract: An aspiration catheter including a body having a proximal end and an opposite distal tip with a lumen extending in a longitudinal direction therethrough from the proximal end to the distal tip. The aspiration catheter further includes a stabilizing structural member stabilizing the body relative to the inner wall of the vessel to minimize movement and/or radial expansion of the distal tip of the body while subject to aspiration that otherwise may potentially damage the inner wall of the vessel.

Abstract: A catheter system that is actuatable to a deployed state and includes a catheter body and a dilator positioned at least partially within the lumen of the catheter. A distal end of the dilator can be releasably connected to a distal tip of the catheter body. The dilator can be retractable to expand and invert the distal tip and form a funnel shape in the deployed state.

Abstract: Devices described herein include an actuated clot retrieval catheter system. The system includes a catheter having a frame disposed proximate the distal end of the catheter. The frame expands to form a seal with the inner wall of a vessel. In some examples, the frame also captures a clot for removal from the vessel. The frame is manufactured from a shape memory material that can be heat set into a predetermined shape. An electrical connection to an electronic circuit causes a current to run through the frame. The electrical resistance of the shape memory material causes the frame to heat and transition from a martensite to an austenite phase. When the frame is heat set into an expanded configuration, the current causes the frame heat and expand. When the frame is heat set into a closed configuration, the current causes the frame heat and collapse upon a clot.