Abstract: Method for treatment of abnormally fast rate of cell proliferation in the epidermis, by administration of a dipeptide of the formula ##STR1## wherein R is H or CH.sub.3, the pyroglutamic acid moiety being in the L-configuration, and the C-terminal amino acid moiety being in the D-configuration when R is methyl, and the C-terminal carboxyl group may be reduced to --Ch.sub.2 --OH, or is in amide form --CO--NH.sub.2, and cation complexes and physiologically acceptable acid addition salts thereof, the complexes being selected from complexes with Zn.sup.++, Ca.sup.++, Mg.sup.++ and Mn.sup.++.

Abstract: New pentapeptide of the formula ##STR1## in which X.sup.1 and X.sup.2 are the same or different and are OH or NH.sub.2,Y is H or OH,X.sup.3 is CO or CH.sub.2,one of the groups Z.sup.1 and Z.sup.2 is H and the other is H or CH.sub.3,all the amino acid unit being in L-configuration, with the exception that the C-terminal amino acid unit is in D-configuration when Z.sup.2 is methyl,and the C-terminal carboxyl group may be reduced to --CH.sub.2 --OH or be in amide form, and cation complexes and salts thereof.The pentapeptide may be prepared by subjecting a protected derivative thereof to deprotection.The pentapeptide has cell growth regulatory activity.

Abstract: The invention relates to physiologically active compounds which are coupling products between an N-acyl aspartic acid and a biologically active amine such as dopamine or serotonin.