Patents by Inventor Karl Mannhardt
Karl Mannhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4855489Abstract: The present invention covers a novel series of 2-acyloxypropylamine derivatives, processes for preparing them, compositions containing them, and methods for using them. The compounds are active in the inhibition of protein kinase C and thrombocyto aggregation stimulated by diacylglycerols.Type: GrantFiled: July 15, 1987Date of Patent: August 8, 1989Assignee: Goedecke AktiengesellschaftInventors: Uwe Trostmann, Christoph Schachtele, Karl Mannhardt, Claus Rudolph, Dieter Marme
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Patent number: 4762837Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arterioschlerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.Type: GrantFiled: May 29, 1987Date of Patent: August 9, 1988Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4760081Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radicals or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carboxyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharmacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.Type: GrantFiled: January 28, 1987Date of Patent: July 26, 1988Assignee: Goedecke AktiengesellschaftInventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4751228Abstract: The present invention provides 1,6-naphthyridine derivatives of formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring or an unsubstituted or substituted condensed aromatic or heterocyclic ring system, R.sup.2 is a straight-chained or branched alkyl radical containing up to 4 carbon atoms, a benzyl radical or a straight-chained or branched, substituted or unsubstituted aminoalkyl radical containing up to 8 carbon atoms, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical, in each case containing up to 4 carbon atoms, R.sup.4 is a straight-chained or branched hydrocarbon radical containing up to 21 carbon atoms, which can also contain oxygen, sulphur, nitrogen or halogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems, or is an amino, cyano, formyl, halogenomethyl or dihalomethyl radical and R.sup.Type: GrantFiled: January 28, 1987Date of Patent: June 14, 1988Assignee: Goedecke AktiengesellschaftInventors: Jorgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Gerhard Satzinger, Dieter Muster, Wolfgang Steinbrecher, Bernd Wagner, Hartmut Osswald
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Patent number: 4720499Abstract: The present invention provides a unique series of pyrido[4,3-b][1,6]naphthyridine derivatives. The compounds are calcium antagonists and are useful for blood vessel diseases. This invention also covers processes for preparing the compounds, pharmaceutical compositions containing them, and methods for using them.Type: GrantFiled: March 9, 1987Date of Patent: January 19, 1988Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Karl Mannhardt, Bernd Wagner, Gunter Weinheimer
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Patent number: 4711901Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromtic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carbonyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharamacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.Type: GrantFiled: July 30, 1986Date of Patent: December 8, 1987Inventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4698341Abstract: New 1,6-naphthyridinone derivatives of the formula I ##STR1## are herein described wherein R.sup.1 represents an unsubstituted or substituted aromatic or heteroaromatic ring;R.sup.2 is hydrogen, a straight-chained or branched alkyl, alkoxyalkyl, or a substituted or unsubstituted aminoalkyl group with up to ten carbon atoms;R.sup.3 is hydrogen, a straight-chained or branched alkyl group, or an alkoxycarbonyl radical with up to four carbon atoms;R.sup.4 is hydrogen, or a morpholinoethyl group;R.sup.5 is a straight-chained or branched alkyl group with up to four carbon atoms, or an amino group; andR.sup.6 is a carboxyl group, or an alkyl- or alkyloxyalkyl carbonyl radical, containing up to 12 carbon atoms and optionally interrupted by an oxygen, sulphur, or nitrogen atom;as well as optionally the pharmacologically acceptable salts thereof; processes for the preparation of these derivatives and their use in the control of vascular diseases.Type: GrantFiled: July 11, 1985Date of Patent: October 6, 1987Assignee: Godecke AktiengesellschaftInventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Manfred Herrmann, Edgar Fritschi, Horst-Dietmar Tauschel, Bernd Wagner, Gunter Wolf
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Patent number: 4681882Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.Type: GrantFiled: October 16, 1985Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jorgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gonter Weinheimer, Edgar Fritschi
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Patent number: 4681881Abstract: The invention concerns new 5-alkoxy-pyrido[4,3-d]pyrimidine derivatives and pharmacologically acceptable salts thereof, as well as a chemically novel process for their preparation. The new compounds are used in the control of cerebral, cardiac or peripheral vascular diseases or of stenotic symptoms.Type: GrantFiled: January 21, 1986Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Bernd Wagner
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Patent number: 4681885Abstract: The invention concerns new 5-oxo-pyrido[4,3-d]pyrimidine derivatives and the pharmacologically acceptable salts thereof, as well as a chemically novel process for the preparation of the new compounds and their use in the control of cerebral, cardiac, or peripheral vascular diseases or of stenotic symptoms.Type: GrantFiled: January 21, 1986Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Bernd Wagner
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Patent number: 4677108Abstract: 4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation.These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.Type: GrantFiled: October 16, 1985Date of Patent: June 30, 1987Assignee: Warner-Lambert CompanyInventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4626546Abstract: The invention is concerned with partially new compounds of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group with up to four carbon atoms and R.sup.2 a substituted phenyl radical and the pharmacologically acceptable salts thereof.The compounds can be prepared according to known procedures and show surprisingly a cardiovascular efficacy. They are capable of decompensating cardiac insufficiencies to a large extent. In addition to the new compounds, claim is also made for pharmaceutical compositions which contain compounds according to the general formula and their application for controlling cardiac and vascular diseases.Type: GrantFiled: August 3, 1984Date of Patent: December 2, 1986Assignee: Warner-Lambert CompanyInventors: Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Manfred Herrmann, Edgar Fritschi, Wolfgang Steinbrecher