Patents by Inventor Karl O. Voss
Karl O. Voss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20190064108Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: April 24, 2018Publication date: February 28, 2019Applicant: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N.K. Lau
-
Patent number: 9964517Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: GrantFiled: March 7, 2017Date of Patent: May 8, 2018Assignee: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N. K. Lau
-
Publication number: 20170269031Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: March 7, 2017Publication date: September 21, 2017Applicant: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N.K. Lau
-
Patent number: 9625416Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: GrantFiled: October 23, 2015Date of Patent: April 18, 2017Assignee: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N. K. Lau
-
Patent number: 9400277Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: GrantFiled: November 19, 2010Date of Patent: July 26, 2016Assignee: ProteinSimpleInventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
-
Publication number: 20160103097Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: October 23, 2015Publication date: April 14, 2016Inventors: Karl O. Voss, Aldrich N.K. Lau
-
Patent number: 9304133Abstract: Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.Type: GrantFiled: April 22, 2011Date of Patent: April 5, 2016Assignee: ProteinSimpleInventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
-
Patent number: 8734630Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: GrantFiled: September 13, 2012Date of Patent: May 27, 2014Assignee: Applied Biosystems, LLC.Inventors: Karl O. Voss, Aldrich N. K. Lau
-
Publication number: 20140106372Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: September 27, 2013Publication date: April 17, 2014Applicant: PROTEINSIMPLEInventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
-
Publication number: 20140090980Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: August 23, 2013Publication date: April 3, 2014Applicant: Applied Biosystems, LLCInventors: Karl O. VOSS, Aldrich N.K. LAU
-
Patent number: 8512537Abstract: Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS and/or TAPSO, and, optionally, a chelating agent, such as EDTA. Methods of separating samples containing bio-molecules, such as DNA or RNA, are also described.Type: GrantFiled: January 28, 2011Date of Patent: August 20, 2013Assignee: Applied Biosystems, LLCInventors: Kevin J. Hacker, Karl O. Voss
-
Publication number: 20130105314Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: September 12, 2012Publication date: May 2, 2013Applicant: APPLIED BIOSYSTEMS, LLCInventors: Karl O. VOSS, Aldrich N. LAU
-
Publication number: 20130105315Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: September 13, 2012Publication date: May 2, 2013Applicant: APPLIED BIOSYSTEMS, LLC.Inventors: Karl O. VOSS, Aldrich N.K. Lau
-
Patent number: 8366900Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: GrantFiled: March 16, 2010Date of Patent: February 5, 2013Assignee: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N. K. Lau
-
Patent number: 8221607Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: GrantFiled: March 5, 2004Date of Patent: July 17, 2012Assignee: Applied Biosystems, LLCInventors: Karl O. Voss, Aldrich N. K. Lau
-
Publication number: 20110195527Abstract: Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.Type: ApplicationFiled: April 22, 2011Publication date: August 11, 2011Applicant: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
-
Publication number: 20110186432Abstract: Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS and/or TAPSO, and, optionally, a chelating agent, such as EDTA. Methods of separating samples containing bio-molecules, such as DNA or RNA, are also described.Type: ApplicationFiled: January 28, 2011Publication date: August 4, 2011Applicant: APPLIED BIOSYSTEMS, LLCInventors: Kevin J. Hacker, Karl O. Voss
-
Publication number: 20110132761Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: November 19, 2010Publication date: June 9, 2011Applicant: Cell Biosciences, Inc.Inventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
-
Patent number: 7935479Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are described herein. In some embodiments a method includes resolving one or more analytes in a fluid path, such as, for example, a capillary. After the one or more analytes are resolved, the one or more analytes are bound to the fluid path upon activation of one or more triggerable agents disposed within the fluid path. The one or more analytes that are bound to the fluid path are detected within the fluid path.Type: GrantFiled: March 19, 2007Date of Patent: May 3, 2011Assignee: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
-
Publication number: 20110000787Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.Type: ApplicationFiled: March 16, 2010Publication date: January 6, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Karl O. VOSS, Aldrich N. Lau