Patents by Inventor Karl Patrick Gilbert

Karl Patrick Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11497833
    Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: November 15, 2022
    Assignee: 3-D Matrix, Ltd.
    Inventors: Eun Seok Gil, Marika Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
  • Publication number: 20220160939
    Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 26, 2022
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
  • Publication number: 20220001047
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Application
    Filed: July 10, 2021
    Publication date: January 6, 2022
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Patent number: 11090398
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 17, 2021
    Assignee: 3-D Matrix, Ltd.
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Publication number: 20210170073
    Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
    Type: Application
    Filed: May 4, 2020
    Publication date: June 10, 2021
    Inventors: Eun Seok Gil, Marc Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
  • Patent number: 10961274
    Abstract: Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 30, 2021
    Assignee: 3-D Matrix, Ltd.
    Inventors: Eun Seok Gil, Marc Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
  • Publication number: 20200190144
    Abstract: Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 18, 2020
    Inventors: Eun Seok Gil, Marc Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
  • Patent number: 10369237
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 6, 2019
    Assignee: 3-D Matrix, LTD.
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Publication number: 20190111165
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Application
    Filed: October 26, 2018
    Publication date: April 18, 2019
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Publication number: 20180023049
    Abstract: Synthetic peptide hydrogel solutions having a pH level of about 3.5 or less and a tonicity within an isotonic osmolality range for use in cell culture experimentation. Related kits and cell culture methods are also disclosed.
    Type: Application
    Filed: February 25, 2016
    Publication date: January 25, 2018
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Publication number: 20170360990
    Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising or consisting essentially of serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 21, 2017
    Inventors: Eun Seok Gil, Marc Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
  • Publication number: 20170202986
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Application
    Filed: March 10, 2015
    Publication date: July 20, 2017
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Publication number: 20170173105
    Abstract: Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.
    Type: Application
    Filed: March 10, 2015
    Publication date: June 22, 2017
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
  • Publication number: 20170173221
    Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
    Type: Application
    Filed: March 10, 2015
    Publication date: June 22, 2017
    Applicant: 3-D MATRIX, LTD.
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
  • Publication number: 20170072008
    Abstract: Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
    Type: Application
    Filed: March 10, 2015
    Publication date: March 16, 2017
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
  • Publication number: 20160362451
    Abstract: The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).
    Type: Application
    Filed: March 10, 2015
    Publication date: December 15, 2016
    Inventors: Eun Seok Gil, Karl Patrick Gilbert, Manav Mehta