Abstract: Methods, apparatus, systems, and articles of manufacture to extend brake life cycle are disclosed herein. An example vehicle includes a first brake associated with a first wheel of the vehicle, a second brake associated with a second wheel of the vehicle, memory, and a brake controller to execute instructions to detect a first parking event, determine, via a first sensor, a condition of the vehicle, access, from the memory, a record of a second parking event including an activation of the first brake, the second parking event preceding the first parking event, and in response to determining the condition satisfies a threshold, engage the second brake without engaging the first brake.

Abstract: The present invention relates to an anti-CD47 antibody or an antigen-binding fragment thereof, comprising variable heavy chain complementarity determining regions 1 to 3 (CDRH1, CDRH2, CDRH3) and variable light chain complementarity determining regions 1 to 3 (CDRL1, CDRL2, CDRL3). The anti-CD47 antibody or an antigen-binding fragment thereof is capable of blocking the interaction of CD47 with signal regulatory protein alpha (SIRPalpha). Further envisaged is an anti-CD47 antibody or antigen-binding fragment combined to a further functional component.

Abstract: The invention relates to a hydraulic circuit for colter pressure and blower rotational speed adjustment at an agricultural spreading machine, with a first line region, which is configured to be connected to at least one colter pressure adjustment cylinder and to specify a hydraulic pressure to the colter pressure adjustment cylinder, a second line region which is configured to be connected to a hydraulically drivable blower and to specify a hydraulic pressure to the blower, and a hydraulic valve for adjusting the hydraulic pressure in the first line region and the hydraulic pressure in the second line region.

Abstract: The invention relates to a hydraulic circuit for colter pressure adjustment at an agricultural spreading machine, with a first line region which is configured to be connected to a first colter pressure adjustment cylinder and to specify a hydraulic pressure to the first colter pressure adjustment cylinder, a first pressure limitation valve which is configured to limit the hydraulic pressure in the first line region to a first maximum pressure, a second line region which is configured to be connected to a second colter pressure adjustment cylinder and to specify a hydraulic pressure to the second colter pressure adjustment cylinder, and a second pressure limitation valve which is configured to limit the hydraulic pressure in the second line region to a second maximum pressure.

Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.

Abstract: Aspects of the present disclosure relate to image data verification. In examples, a discrete cosine transform (DCT) is performed on image data and used to generate a set of DCT coefficients. In some instances, multiple block sizes are used when processing the image data, such that a set of DCT coefficients is generated for each block size. The resulting sets of DCT coefficients for the plurality of block sizes may be processed according to an expected distribution to determine whether the content of the image data is likely to be authentic or likely to be altered, such that an indication may be provided in association with the image data accordingly.

Abstract: Methods and apparatus are disclosed for efficient factor analysis of a large population of data records, using factors that are categorical variables. Computation is balanced between extracting key factors by training a machine learning classifier on a reduced sample of data records, for computational efficiency, and scoring the categorical values of the key factors on the entire population, for accuracy of results. A joint factor is constructed by combining all proposed root factors, and the sample is generated by stratified sampling on the joint factor. The key factors are selected from candidate factors which can be combinations of the root factors. Original variables of a dataset, whether categorical or not, can be binned to obtain new categorical factors. Variations and user interfaces are also disclosed.

Abstract: A device for manual application of a liquid. The device may be used for painting, marking, drawing, writing and/or applying make-up to keratinous surfaces. The device includes a capillary store for the liquid, the capillary store having a filing level, and a measuring device for measuring the filing level of the capillary store.

Abstract: The invention relates to a medical device comprising a printable electrical component (1), the printable electrical component (1) comprising a plastic substrate (L1) wherein at least electrical component (E) is applied to the plastic substrate, wherein the electrical component (E) comprises a dried conductive ink, wherein the plastic substrate is selected from the group comprising polycarbonate, cycloolefin copolymers, polymethylacrylate, polypropylene and wherein the dried conductive ink comprise silver and/or gold, wherein the electrical component (E) comprises feather-like and/or meander-like and/or spiral-shaped sections, whereby the medical device further comprises a fluid line, wherein the printable electrical component is located on the outside of the fluid line.

Abstract: A braking system for a motor vehicle includes a hydraulic service brake for braking the motor vehicle in driving operation, an electric parking brake for holding the motor vehicle at a standstill, and an electronic control system for automatically controlling the parking brake and the service brake. The electronic control system may be adapted to activate the parking brake, with the service brake activated, after the motor vehicle has been braked to the standstill via the activated service brake, and to at least partly deactivate the activated service brake after the parking brake has been activated. The electronic control system may also be adapted to deactivate the activated parking brake following operation of an accelerator pedal of the motor vehicle.

Abstract: In one example in accordance with the present disclosure, a method is described. The example method determining parameters for a pulsed laser to generate a melt pool pattern in a three-dimensional (3D) object to produce different phases in the 3D object that vary according to the melt pool pattern. The example method also includes controlling the pulsed laser to form the 3D object in an additive manufacturing process based on the determined parameters and the melt pool pattern.

Abstract: The invention relates to a method for dynamic load simulation, wherein loads are specified by target signals and applied to a test object by a parallel kinematic excitation unit via an end effector, including the following operations: measuring loads at a contact point (200), comparing the measured loads with the target signals (300), and determining target pressures (400) for individual actuators of the parallel kinematic excitation unit for applying the target signals by use of a control algorithm (Fq,ref). This provides a method for dynamic load simulation that reduces the time and cost expenditure compared to previously known methods and at the same time enables hardware-in-the-loop simulations to be used.

Abstract: Methods, apparatus, systems, and articles of manufacture to extend brake life cycle are disclosed herein. An example vehicle includes a first brake associated with a first wheel of the vehicle, a second brake associated with a second wheel of the vehicle, memory, and a brake controller to execute instructions to detect a first parking event, determine, via a first sensor, a condition of the vehicle, access, from the memory, a record of a second parking event including an activation of the first brake, the second parking event preceding the first parking event, and in response to determining the condition satisfies a threshold, engage the second brake without engaging the first brake.

Abstract: In some embodiments the disclosure is directed to a closed-loop piston engine system using a recirculating carbon dioxide (CO2) system with supercritical carbon dioxide (scCO2) as a working fluid. The closed-loop piston engine system may include a scCO2 injector; a superheating nozzle region; a first valve; a second valve; a piston moving in the cylinder and coupled with a crankshaft, the piston being driven toward a centerline of the crankshaft during a power stroke using a connecting rod and causing the crankshaft to rotate thereby causing one power stroke per piston per crankshaft rotation and thereby producing two power strokes for every single power stroke that a similar engine would produce if run as a hydrocarbon fuel powered internal combustion engine. The recirculating CO2 system recirculates the used carbon dioxide and there are no carbon dioxide emissions from the system.

Abstract: The invention relates to a medical device comprising a printable electrical component (1), the printable electrical component (1) comprising a plastic substrate (L1) wherein at least electrical component (E) is applied to the plastic substrate, wherein the electrical component (E) comprises a dried conductive ink, wherein the plastic substrate is selected from the group comprising polycarbonate, cycloolefin copolymers, polymethylacrylate, polypropylene and wherein the dried conductive ink comprise silver and/or gold, wherein the electrical component (E) comprises feather-like and/or meander-like and/or spiral-shaped sections, whereby the medical device further comprises a fluid line, wherein the printable electrical component is located on the outside of the fluid line.

Abstract: Embodiments of the present invention provide for systems and methods for dynamically synthesizing audio files on a mobile device. Embodiments of the present invention are directed to an exemplary audio file recorder with unique music-related features, such as synchronization of multiple pieces of content by the beats per minute, with functionality for content creation, editing, layering of multiple tracks, and sharing. Further, embodiments of the present invention are also related to an exemplary computer software platform which allows users to record any audio into their mobile device and organize the audio files in a manner that allows the files to be easily retrieved and shared.

Abstract: A pen comprising a shaft, a gripping zone, and a measuring device having a sensor configured to measure a force acting on the gripping zone. The pen further comprises a cover in the area of the gripping zone, the cover configured to cover the measuring device.

Abstract: The invention relates to Electronic pen (100) with pen position detection, comprising at least a writing lead, at least one electric voltage source, at least one digital processing unit, at least one data transfer module, and an inertial position detection sensor system for determining the location and movement of the electronic pen (100), wherein the electronic pen (100) is configured for an initial specification of a writing coordinate system with two axes X, Y (107, 108) being orthogonal to each other on a two-dimensional writing substrate (106) and with an axis Z being perpendicular to the two-dimensional writing substrate, characterized in that the inertial position detection sensor system is configured for the determination of accelerations and acceleration profiles of the electronic pen along the X-axis (107) and along the Y-axis (108) for a plurality of pairs of different axis orientations of the X-axis and Y-axis on the writing substrate (106), whereby for each pair of axis orientations, the axis ori

Abstract: A sowing machine has row units, where each of the row units includes tillage tools and a hydraulic cylinder which applies a coulter pressure upon the tillage tools that is adjustable by a pressure valve. Further, a sensor arrangement includes at least two sensors for producing an electrical signal in connection with a total pressure acting upon the tillage tools of each row unit. In addition, an open-loop or closed-loop control device is connected to the pressure valves and the sensor arrangement and configured to adjust the coulter pressure of each row unit individually and to adapt it on the basis of the electrical signals of the sensor arrangement. In order to create a sowing machine with individual coulter pressure control that is inexpensive to manufacture, a reduced number of sensors is advantageously employed by using a functional relationship.

Abstract: The invention relates to a load simulation test stand having at least one hydraulic test cylinder (1) which comprises at least one cylinder chamber (1a, 1b) which can be charged with hydraulic fluid, preferably two cylinder chambers (1a, 1b) which can be charged with hydraulic fluid and which act counter to one another, in the case of which load simulation test stand the at least one test cylinder (1), in particular each of multiple provided test cylinders (1), comprises at least one capacity element (5, 6, 7), preferably a capacity element (5, 6, 7) which is exchangeable or which is adjustable in terms of hydraulic capacity, by means of which the hydraulic overall capacity of the at least one cylinder chamber (1a, 1b) can be adjusted.