Patents by Inventor Karl Petzoldt

Karl Petzoldt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-Hydroxy steroids, a process for the production thereof, and pharmaceutical preparations containing them
    Patent number: 4307088
    Abstract: 1-Hydroxy steroids of formula I ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen or alkanoyl of 1-8 carbon atoms are distinguished by strong progestational activity and only very minor androgenic side effects.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: December 22, 1981
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Rudolf Wiechert, Hermann Steinbeck, Walter Elger
  • Process for the preparation of 19-hydroxy steroids of the androstane and pregnane series
    Patent number: 4284720
    Abstract: 10-Methyl steroids of the androstane or pregnane series are converted to the corresponding 19-hydroxy steroid by fermentation with a fungal culture of the genus Nigrospora.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: August 18, 1981
    Assignee: Schering, A.G.
    Inventor: Karl Petzoldt
  • Novel corticoids
    Patent number: 4196203
    Abstract: Compounds of the formula ##STR1## wherein X is .beta.-CH.sub.2 OH or CO and R.sub.2 is F, Cl or CH.sub.3, and their physiologically acceptable 21-esters are useful for the treatment of allergic diseases of the respiratory tract and for the treatment of topical and systemic inflammatory conditions.
    Type: Grant
    Filed: December 9, 1977
    Date of Patent: April 1, 1980
    Assignee: Schering Aktiengesellschaft
    Inventors: Joachim-Friedrich Kapp, Klaus Kieslich, Henry Laurent, Karl Petzoldt
  • Hydroxylated 1 alpha, 2 alpha-methylene steroids
    Patent number: 4196204
    Abstract: Steroids of the formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each is hydrogen or the residue of an organic or inorganic acid,and for the esters (R.sub.1 or R.sub.2 is not H) capable of salt formation, the salts thereof, possess valuable pharmacological properties, e.g., good antiandrogenic activity with low progestational activity.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: April 1, 1980
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Hermann Steinbeck, Walter Elger
  • Novel .alpha.-hydroxy steroids
    Patent number: 4144334
    Abstract: 1.alpha.-Oxysteroid of the formula ##STR1## wherein R.sub.1 is methyl or ethyl,R.sub.2 and R.sub.3 each are hydrogen or alkanoyl of 1-8 carbon atoms, andR.sub.4 is hydrogen or hydrocarbon of 1-4 carbon atoms,Are progestestionally active and useful in oral contraceptive and menopausal compositions.
    Type: Grant
    Filed: February 10, 1977
    Date of Patent: March 13, 1979
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Walter Elger
  • Novel agents and novel methods for inducing abortions
    Patent number: 4124708
    Abstract: Novel agents and methods for triggering abortions employ a compound of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 and R.sub.3 are hydrogen or alkanoyl of 1-8 carbon atoms, and R.sub.4 is hydrogen or ethynyl.
    Type: Grant
    Filed: March 25, 1977
    Date of Patent: November 7, 1978
    Assignee: Schering, A.G.
    Inventors: Walter Elger, Karl Petzoldt
  • D-Homo-20-ketopregnanes
    Patent number: 4045574
    Abstract: D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is oxygen, ##STR2## in which R.sub.5 is hydrogen or lower acyl; R.sub.2 is hydrogen or methyl; R.sub.3 is oxygen, ##STR3## or two hydrogen atoms; R.sub.4 is hydrogen, hydroxy or acyloxy; R.sub.6 is hydrogen or methyl; and R.sub.7 is hydrogen, acetyl, hydroxy or lower acyloxy in the .alpha.- or .beta.-position possess CNS-depressant activity, including anesthesia upon parenteral administration, and are produced by hydrogenating the corresponding steroids having double bonded C.sub.5 and/or C.sub.16 carbon atoms.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: August 30, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt, Helmut Wachtel, Dieter Palenschat, Reinhard Horowski, Gert Paschelke, Wolfgang Kehr
  • Process for the preparation of estrene-3,17-dione derivatives
    Patent number: 4036695
    Abstract: Estrene-3,17-diones of the formula ##STR1## wherein X is oxo, or ketalized oxo, preferably alkylenedioxy of 2-6 carbon atoms or o-phenylenedioxy;.DELTA. is a carbon atom linked to the adjacent carbon atoms by a double bond and two single bonds;R.sub.1 is methyl or ethyl, andR.sub.2 and R.sub.3 collectively are a carbon-to-carbon bond or methylene, useful as intermediates for the production of pharmacologically active steroids, are prepared by fermenting 18-ethyl-4-estrene-3,17-dione or 18-methyl-4-estrene-3,17-dione with a fungal culture of the genus Penicillium or Fusarium to produce the corresponding 15.alpha.-hydroxy-steroid;In either order, converting the hydroxy group of the thus-produced 15.alpha.-hydroxy steroid to a sulfonic acid ester thereof and ketalizing the 3-keto group thereof; andTreating the ketalized and esterified steroid with a base to form a .DELTA..sup.15 -compound or with dimethylsulfoxonium methylide to form a 15.beta.,16.beta.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: July 19, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Rudolf Wiechert
  • 1.alpha.-Hydroxy steroids
    Patent number: 4029779
    Abstract: 1.alpha.-Oxysteroid of the formula ##STR1## wherein R.sub.1 is methyl or ethyl,R.sub.2 and R.sub.3 each are hydrogen or alkanoyl of 1-8 carbon atoms, andR.sub.4 is hydrogen or hydrocarbon of 1-4 carbon atoms,Are progestestionally active and useful in oral contraceptive and menopausal compositions.
    Type: Grant
    Filed: October 17, 1975
    Date of Patent: June 14, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Walter Elger
  • D-homosteroids
    Patent number: 4026921
    Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. These compounds exhibit anti-inflammatory activity.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: May 31, 1977
    Inventors: Andor Furst, Marcel Muller, Leo Alig, Peter Keller, Ulrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt
  • D-homosteroids
    Patent number: 4026918
    Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. The novel D-homosteroids exhibit anti-inflammatory activity and are useful intermediates for the synthesis of anti-inflammatory D-homosteroids.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: May 31, 1977
    Inventors: Andor Furst, Marcel Muller, Leo Alig, Peter Keller, Ulrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt
  • 7-Hydroxyestradiols
    Patent number: 4011314
    Abstract: 7-Hydroxyestradiols of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, cycloalkyl, an oxygenated saturated heterocyclic group or hydrocarbylsulfonyl; R.sub.2 and R.sub.3 each are hydrogen, acyl, oxygenated saturated heterocyclic group or R.sub.2 is hydrocarbylsulfonyl and R.sub.4 is alkyl, alkenyl, chlorinated alkenyl, alkynyl or chlorinated alkynyl, are useful for treating estrogen deficiency symptoms.
    Type: Grant
    Filed: October 9, 1975
    Date of Patent: March 8, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Hans-Jorg Vidic, Klaus Prezewowsky, Yukishige Nishino, Rudolf Wiechert, Henry Laurent
  • Radioactively labeled steroid derivatives
    Patent number: 3935245
    Abstract: Steroids bearing the substituent --X-NR.sub.1 R.sub.2 wherein --NR.sub.1 R.sub.2 is a tritium of carbon-14 labeled amino or amino-acid group and --X-- is --R.sub.3 --, --OCOR.sub.3 --, =N--O--R.sub.3 -- or --NHCOR.sub.3 -- wherein R.sub.3 is --(CH.sub.2).sub.n CO-- in which n is 0-4, are useful as diagnostic agents.
    Type: Grant
    Filed: June 4, 1974
    Date of Patent: January 27, 1976
    Assignee: Schering Aktiengesellschaft
    Inventors: Otto Engelfried, Bob Nieuweboer, Karl Petzoldt, Ulrich Kerb, Klaus Lubke