Patents by Inventor Karl-Siegfried Boos

Karl-Siegfried Boos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7608189
    Abstract: A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: October 27, 2009
    Assignee: B. Braun Medizintechnologie GmbH
    Inventors: Dietrich Seidel, Karl-Siegfried Boos
  • Publication number: 20090211976
    Abstract: A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.
    Type: Application
    Filed: May 6, 2009
    Publication date: August 27, 2009
    Inventors: Dietrich SEIDEL, Karl-Siegfried BOOS
  • Patent number: 7553482
    Abstract: The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: June 30, 2009
    Assignee: Novartis International Pharmaceutical Ltd
    Inventors: Dietrich Seidel, Karl-Siegfried Boos
  • Publication number: 20090123566
    Abstract: The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.
    Type: Application
    Filed: January 12, 2009
    Publication date: May 14, 2009
    Inventors: Dietrich Seidel, Karl-Siegfried Boos
  • Publication number: 20050217994
    Abstract: The use of a support material for capillary electrochromatography is disclosed, wherein the support material, which is based on a base material containing hydroxy groups, has reversed phases which are limited to the inner surfaces of porous particles, said reversed phases consisting of fatty acid residues. Further, separating capillaries suitable for such a use are disclosed.
    Type: Application
    Filed: May 23, 2005
    Publication date: October 6, 2005
    Inventors: Klaus Unger, Karl-Siegfried Boos, Angelika Muscate-Magnussen, Dieter Lubda
  • Publication number: 20050009001
    Abstract: A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 13, 2005
    Inventors: Dietrich Seidel, Karl-Siegfried Boos
  • Publication number: 20040186073
    Abstract: The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 23, 2004
    Inventors: Dietrich Seidel, Karl-Siegfried Boos
  • Publication number: 20030080056
    Abstract: The invention relates to a process for the obtainment of biological components from body fluids, in particular from blood, blood plasma or serum. The biological components are obtained in native and biologically active form and can be employed, for example, for therapeutic purposes and for the preparation of control samples or standards for diagnostic tests.
    Type: Application
    Filed: October 22, 2002
    Publication date: May 1, 2003
    Inventors: Karl-Siegfried Boos, Seidel Dietrich
  • Patent number: 6103126
    Abstract: The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: August 15, 2000
    Assignee: SeBo GmbH
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Klaus Spengler, Gudrun Henke, Andreas Rauh
  • Patent number: 6074555
    Abstract: The invention relates to improved chromatographic support materials, to the preparation thereof and to the use thereof as sorbent for chromatography. The particles of these materials have hydrophobic surfaces consisting of fatty acid esters in the pores and hydrophilic outer surfaces. The materials according to the invention permit direct separation of protein-containing samples by means of reverse phase methods.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: June 13, 2000
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Karl Siegfried Boos, Andreas Walfort, Friedhelm Eisenbeiss, Dieter Lubda
  • Patent number: 5846426
    Abstract: The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: December 8, 1998
    Assignee: B. Braun Melsungen AG
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Klaus Spengler, Gudrun Henke, Andreas Rauh
  • Patent number: 5795786
    Abstract: A process and a reagent for the specific and direct determination of the LDL-fraction in the presence of other serum lipoproteins by adding a polymeric LDL-aggregating agent, followed by direct turbidimetric measurement of the LDL aggregate. Preferred are polymers which have a comb or brush type structure with the side groups having acid character, such as branched alkane sulfonic acids.
    Type: Grant
    Filed: August 6, 1996
    Date of Patent: August 18, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Wolf-Dieter Engel, Angelika Kurrle-Weittenhiller
  • Patent number: 5679775
    Abstract: In order to remove tumor necrosis factor .alpha. (TNF.alpha.) or/and bacterial lipopolysaccharides (LPS, endotoxin) extracorporeally from whole blood or/and blood plasma in an extracorporeal perfusion system, the blood or plasma is passed over a cation exchanger and an anion exchanger material. A device according to the invention for the extracorporeal treatment of patient's blood or plasma therefore contains a cation exchanger material and an anion exchanger material wherein these materials are contained in at least one compartment of an extracorporeal perfusion system.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: October 21, 1997
    Assignee: B. Braun Melsungen AG.
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Annette Trautwein, Gerold Morsch
  • Patent number: 5679260
    Abstract: Disclosed is a process to remove tumour necrosis factor .alpha. (TNF.alpha.) or/and bacterial lipopolysaccharides (LPS) from an aqueous liquid, in particular blood, blood plasma or serum, in an extracorporeal perfusion system after removing corpuscular blood components if necessary, wherein(a) the pH value of the body fluid is adjusted to pH<6,(b) a precipitation reagent in the form of a polyanion is added,(c) precipitated substances are removed by filtration or/and centrifugation and(d) the resulting liquid is passed over an anion exchanger.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: October 21, 1997
    Assignee: B. Braun Melsungen AG
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Annette Trautwein, Gerold Morsch
  • Patent number: 5514281
    Abstract: The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: May 7, 1996
    Assignee: B. Braun Melsungen AG
    Inventors: Karl-Siegfried Boos, Dietrich Seidel, Klaus Spengler, Gudrun Henke, Andreas Rauh
  • Patent number: 5403917
    Abstract: For the quantitative selective removal or/and preparative isolation of tumour necrosis factor (TNF) or/and lipopolysaccharides from aqueous liquids, in particular blood, plasma or serum, the aqueous liquid is passed over an adsorption material which consists of a porous supporting material to which functional groups made of synthetic or/and semisynthetic or/and natural polyanion chains and namely in a linear or branched form, are covalently bound and if desired, the molecules chromatographically separated in this way are eluted from the adsorption material using a saline solution.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: April 4, 1995
    Assignee: B. Braun Melsungen, AG
    Inventors: Karl-Siegfried Boos, Dietrich Siedel, Friedrich von der Haar