Patents by Inventor Karl Thierauch

Karl Thierauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkynylpyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
    Patent number: 8642611
    Abstract: The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: February 4, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ingo Hartung, Ulrich Bothe, Georg Kettschau, Ulrich Luecking, Anne Mengel, Martin Krueger, Karl Thierauch, Philip Lienau, Ulf Boemer
  • Alkynylpyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
    Patent number: 8524724
    Abstract: The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: September 3, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ingo Hartung, Ulrich Bothe, Georg Kettschau, Ulrich Luecking, Anne Mengel, Martin Krueger, Karl Thierauch, Philip Lienau, Ulf Boemer
  • Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridones
    Publication number: 20070135489
    Abstract: Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected.
    Type: Application
    Filed: January 18, 2007
    Publication date: June 14, 2007
    Inventors: Andreas Huth, Martin Krueger, Ludwig Zorn, Stuart Ince, Rolf Bohlmann, Karl Thierauch, Andreas Menrad, Martin Haberey, Holger Hess-Stumpp
  • VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
    Publication number: 20050054654
    Abstract: VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as intermediate products for the production of the compounds are described. The compounds according to the invention can be used as or in the case of tumor or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as, e.g.
    Type: Application
    Filed: June 18, 2004
    Publication date: March 10, 2005
    Inventors: Andreas Huth, Ludwig Zorn, Martin Krueger, Stuart Ince, Karl Thierauch, Andreas Menrad, Martin Haberey, Holger Hess-Stumpp
  • VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
    Publication number: 20050049281
    Abstract: Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected.
    Type: Application
    Filed: June 14, 2004
    Publication date: March 3, 2005
    Inventors: Andreas Huth, Martin Krueger, Ludwig Zorn, Stuart Ince, Rolf Bohlmann, Karl Thierauch, Andreas Menrad, Martin Haberey, Holger Hess-Stumpp
  • 9-substituted bicyclo[3.3.0]octane derivatives, process for their production and their pharmaceutical use
    Patent number: 5405988
    Abstract: The invention relates to 9-substituted bicyclo[3.3.0]octane derivatives of formula I, ##STR1## and their salts with physiologically compatible bases, as well as the .alpha.-, .beta.- or .gamma.-cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: April 11, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Helmut Vorbruggen, Hartmut Rehwinkel, Karl Thierauch, Peter Verhallen