Abstract: A tubing assembly for use with an electronic catheter guidance systems is provided and includes a catheter and a stimulation electrode assembly, and an electrical connection for delivering a stimulation waveform to the stimulation electrode assembly. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The stimulation electrode assembly is configured to deliver an electrical stimulation to tissue. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

Abstract: A tubing assembly for use with an electronic catheter guidance systems is provided and includes a catheter and a stimulation electrode assembly, and an electrical connection for delivering a stimulation waveform to the stimulation electrode assembly. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The stimulation electrode assembly is configured to deliver an electrical stimulation to tissue. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

Abstract: A tubing assembly for use with electronic catheter guidance systems is provided and includes a catheter, an ultrasound transducer disposed within the catheter, and an optional additional external ultrasound transducer. The catheter extends in a longitudinal direction and has a proximal end and a distal end defining a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract or respiratory tract. The ultrasound transducer can be located within the catheter's lumen, and the optional external ultrasound transducer can be located on or outside the patient's body. Both ultrasound transducers can transmit ultrasound signals as directed by a processor and can communicate with the processor to deliver ultrasound data to a display device. The attenuation of the ultrasound energy at a selected frequency can indicate placement of the catheter in the digestive tract or respiratory tract. A catheter guidance system and method of use are also provided.

Abstract: A medical device position guidance system includes at least one reference transmitter, a receiver system comprising at least two sensors configured to receive signals from the at least one reference transmitter and move relative to the at least one reference transmitter, and a processor. The at least one reference transmitter is configured to maintain a fixed position relative to a subject. The at least two sensors are enclosed in a unitary receiver housing. The at least one reference transmitter and the receiver system are operatively coupled to the processor. The system also includes a memory device storing instructions which when executed by the processor, cause the processor to receive signals relating to a location and orientation of the receiver system relative to the at least one reference transmitter and using the received signals, create an anatomical coordinate system.

Abstract: A tubing assembly for electronic catheter guidance systems is provided and can include a catheter, an internal acoustic transducer and an external acoustic transducer. The catheter extends in a longitudinal direction and has proximal and distal ends that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive or respiratory tract. The internal acoustic transducer can be located within the catheter's lumen, and the external acoustic transducer can be located on or outside the patient's body. The transducers can transmit and/or receive acoustic signals as directed by a processor and communicate with the processor to deliver sound data to a display device. The frequency response and/or attenuation of the signals can indicate placement of the catheter in the digestive tract compared to the respiratory tract. A catheter guidance system and method for accurately placing a catheter in the digestive or respiratory tract are also provided.

Abstract: A beverage production system is provided that includes a turntable assembly comprising a central axis. The turntable assembly further includes an inner turntable and an outer turntable disposed circumferentially about the inner turntable. The beverage production system also includes a cup dispensing station configured to dispense cups onto one of the inner or outer turntables. The beverage production system also includes a beverage dispensing station configured to dispense a beverage into the cups.

Abstract: A medical device position guidance system is provided. The system includes at least one reference transmitter and a receiver system configured to receive signals from the at least one reference transmitter. The reference transmitter is configured to maintain a static position on a subject. The system further includes a processor configured to (i) receive signals relating to the location and orientation of each sensor of the receiver system relative to the at least one reference transmitter; and (ii) using the received signals, create an anatomical coordinate system. The system may further include an inserted transmitter configured to be attached to a medical device. The inserted transmitter is adapted to establish the location and orientation of the medical device within the anatomical coordinate system. A method for medical device position guidance is also provided.

Abstract: A beverage production system is provided that includes a cup dispensing station configured to dispense cups and a beverage dispensing station configured to dispense a beverage. The beverage production system also includes a turntable assembly having a central axis, an inner turntable including a row of cup receptacles, and an outer turntable disposed circumferentially about the inner turntable. The inner turntable configured to rotate about the central axis to align the cup receptacles of the row with the cup dispensing station and the beverage dispensing station. The turntable assembly configured to align an opening in the turntable assembly with a cup receptacle in the row, the opening adjacent the outer turntable. The beverage production system also having an actuator configured to move a cup positioned in the cup receptacle in the row onto the outer turntable.

Abstract: A tubing assembly for electronic catheter guidance systems is provided and can include a catheter, an internal acoustic transducer and an external acoustic transducer. The catheter extends in a longitudinal direction and has proximal and distal ends that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive or respiratory tract. The internal acoustic transducer can be located within the catheter's lumen, and the external acoustic transducer can be located on or outside the patient's body. The transducers can transmit and/or receive acoustic signals as directed by a processor and communicate with the processor to deliver sound data to a display device. The frequency response and/or attenuation of the signals can indicate placement of the catheter in the digestive tract compared to the respiratory tract. A catheter guidance system and method for accurately placing a catheter in the digestive or respiratory tract are also provided.

Abstract: A compound with the Formula (I): A-B-C??(I) wherein A is of the following formula: where X1 is N B is of formula (B-1) or (B-2) and C is selected from the group consisting of optionally substituted C6-10 carboaryl, C5-6 heteroaryl and C5-10 heterocyclyl and their use as PCSK9 inhibitors.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.

Abstract: A system for analysis of sonar data is provided comprising sonar transducer assembl(ies), processor(s), and a memory. The memory includes computer program code that is configured to, when executed, cause processor(s) to receive sonar data, where an object is represented within sonar data, and additional data from a data source other than the sonar transducer assembl(ies). The processor(s) further determine object characteristic(s) of the object using sonar data and additional data, and determine an estimated object-type for the object represented within sonar data using the object characteristic(s). The processor(s) further generate a sonar image based on sonar data, cause display of the sonar image, and cause provision of an indication of the estimated object-type so that the indication of the estimated object-type is correlated to the object representation in the sonar image.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.

Abstract: A medical device position guidance system is provided. The system includes at least one reference transmitter and a receiver system configured to receive signals from the at least one reference transmitter. The reference transmitter is configured to maintain a static position on a subject. The system further includes a processor configured to (i) receive signals relating to the location and orientation of each sensor of the receiver system relative to the at least one reference transmitter; and (ii) using the received signals, create an anatomical coordinate system. The system may further include an inserted transmitter configured to be attached to a medical device. The inserted transmitter is adapted to establish the location and orientation of the medical device within the anatomical coordinate system. A method for medical device position guidance is also provided.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.

Abstract: A medical device position guidance system is provided. The system includes at least one reference transmitter and a receiver system configured to receive signals from the at least one reference transmitter. The reference transmitter is configured to maintain a static position on a subject. The system further includes a processor configured to (i) receive signals relating to the location and orientation of each sensor of the receiver system relative to the at least one reference transmitter; and (ii) using the received signals, create an anatomical coordinate system. The system may further include an inserted transmitter configured to be attached to a medical device. The inserted transmitter is adapted to establish the location and orientation of the medical device within the anatomical coordinate system. A method for medical device position guidance is also provided.

Abstract: A configurable pathway deviation indication system for medical device placement includes one or more user-adjustable pathway boundaries and an indication activated upon reaching or breaching of any of the pathway boundaries. The system may include a medical device configured to be inserted into a patient; a location transmitter configured to transmit a signal related to a position of the medical device; and a detector device configured to receive information related to the patient's body and the location transmitter. The system may be operatively coupled to the location transmitter and the at least one detector device. The system may further include a display and a computing system comprising one or more processors and or more non-transitory computer-readable media. The system can display the position of the location transmitter; determine if the position of the location transmitter reaches any pathway boundaries; and provide the indication when the pathway boundary is breached and/or approached.

Abstract: An explosive with reduced detonation performance that includes an explosive powder that detonates with a reaction velocity of less than 5000 feet per second, a polymer resin, and an inert filler.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.