Patents by Inventor Karl-Werner Quirin

Karl-Werner Quirin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10568925
    Abstract: The invention concerns carbon dioxide extracts of Curcuma amada (mango ginger), including supercritical carbon dioxide extracts of C. amada; methods for their production; compositions comprising the extracts; methods for treating or delaying the onset of conditions such as cell proliferation disorder (e.g., cancer), inflammation, infection, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, platelet hyper-aggregation, immune disorder such as autoimmune disorder, or neurodegenerative condition; and methods for inhibiting expression of Bcl-2, Bak, and p53 genes; inhibiting expression of the COX-2 and NF-kB genes, inhibiting production of phosphorylated target of rapamycin (TOR), modulating AMP-activated protein kinase (AMPK), inhibiting protein kinase B (AKT) signaling, modulating the Ras/Raf/MEK/ERK signaling pathway, and modulating the Ras/PI3K/PTEN/Akt/mTOR signaling pathway.
    Type: Grant
    Filed: January 31, 2016
    Date of Patent: February 25, 2020
    Assignees: DHARMA BIOMEDICAL, LLC, FLAVEX NATUREXTRAKTE GMBH
    Inventors: Steven J. Melnick, Karl-Werner Quirin, Cheppail Ramachandran, Melvin Rothberg
  • Patent number: 9913870
    Abstract: The subject invention pertains to supercritical carbon dioxide extracts of Commiphora mukul resin (guggul), which can be modified or not modified by some ethanol addition; methods for their production; and methods of use, such as inhibiting HMG-CoA reductase, inhibiting transformation of pre-adipocytes to adipocytes, inhibiting triglyceride storage, promoting insulin sensitivity in adipocytes, treatment of disorders (for example, hypercholesterolemia, hyperlipidemia, hyperglycemia, obesity, metabolic syndrome, cardiovascular disease, atherosclerotic heart disease, autoimmune disorder, insulin resistance, leptin resistance, arthritis, cell proliferation disorder, such as cancer and atherosclerosis; damaged skin, sores, cuts, rashes, bruises, dryness, burns, sunburn, radiation burn, and infection), and regulating or suppressing appetite.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: March 13, 2018
    Assignees: DHARMA BIOMEDICAL, LLC, FLAVEX NATUREXTRAKTE GMBH
    Inventors: Steven J. Melnick, Karl-Werner Quirin, Cheppail Ramachandran, Melvin Rothberg
  • Publication number: 20160220627
    Abstract: The invention concerns carbon dioxide extracts of Curcuma amada (mango ginger), including supercritical carbon dioxide extracts of C. amada; methods for their production; compositions comprising the extracts; methods for treating or delaying the onset of conditions such as cell proliferation disorder (e.g., cancer), inflammation, infection, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, platelet hyper-aggregation, immune disorder such as autoimmune disorder, or neurodegenerative condition; and methods for inhibiting expression of Bcl-2, Bak, and p53 genes; inhibiting expression of the COX-2 and NF-kB genes, inhibiting production of phosphorylated target of rapamycin (TOR), modulating AMP-activated protein kinase (AMPK), inhibiting protein kinase B (AKT) signaling, modulating the Ras/Raf/MEK/ERK signaling pathway, and modulating the Ras/PI3K/PTEN/Akt/mTOR signaling pathway.
    Type: Application
    Filed: January 31, 2016
    Publication date: August 4, 2016
    Inventors: STEVEN J. MELNICK, KARL-WERNER QUIRIN, CHEPPAIL RAMACHANDRAN, MELVIN ROTHBERG
  • Publication number: 20150010615
    Abstract: The subject invention pertains to supercritical carbon dioxide extracts of Commiphora mukul resin (guggul), which can be modified or not modified by some ethanol addition; methods for their production; and methods of use, such as inhibiting HMG-CoA reductase, inhibiting transformation of pre-adipocytes to adipocytes, inhibiting triglyceride storage, promoting insulin sensitivity in adipocytes, treatment of disorders (for example, hypercholesterolemia, hyperlipidemia, hyperglycemia, obesity, metabolic syndrome, cardiovascular disease, atherosclerotic heart disease, autoimmune disorder, insulin resistance, leptin resistance, arthritis, cell proliferation disorder, such as cancer and atherosclerosis; damaged skin, sores, cuts, rashes, bruises, dryness, burns, sunburn, radiation burn, and infection), and regulating or suppressing appetite.
    Type: Application
    Filed: January 11, 2013
    Publication date: January 8, 2015
    Applicants: DHARMA BIOMEDICAL, LLC, FLAVEX NATUREXTRAKTE GMBH
    Inventors: Steven J. Melnick, Karl-Werner Quirin, Cheppail Ramachandran, Melvin Rothberg
  • Publication number: 20080207932
    Abstract: A process of producing kiwifruit seed oil involves first sterilizing the picked and selected ripe kiwifruit by flame, chlorine wash, or ozone impregnated water wash, followed by a fresh water rinse. The fruit is then cut using a water laser to minimize seed damage. Next the skin is separated from the fruit. Then the pulp is gently separated from the seed ensuring minimal seed coat damage. The resulting seed is cleaned whilst ensuring minimal seed coat damage. Then seed is then dried using cool temperature drying. The seed is stored at a cool temperature until it is needed for oil extraction. Crushing of the seed takes place immediately prior to the super critical extraction process. Super critical extraction using liquid carbon dioxide extracts the kiwifruit oil from the crushed seeds. The oil is the stabilized using a natural antioxidant such as rosemary oil.
    Type: Application
    Filed: May 1, 2006
    Publication date: August 28, 2008
    Applicant: VITAL FOOD PROCESSORS LIMITED
    Inventors: Bruce William Donaldson, Karl-Werner Quirin
  • Patent number: 4548755
    Abstract: Process for the extractive production of valuable, natural waxes from fossil and/or freshly grown vegetable and/or animal starting material by extraction of the starting material in an extraction stage with a physiologically unobjectionable gas at supercritical pressure and temperature conditions, separation of the extract-containing gas in a separator part by pressure reduction and/or temperature change, periodical or continuous withdrawal of the extract and return of the separated gas to the extraction stage.
    Type: Grant
    Filed: February 24, 1983
    Date of Patent: October 22, 1985
    Assignee: SKW Trostberg Aktiengesellschaft
    Inventors: Egon Stahl, Karl-Werner Quirin