Abstract: A method is provided for predicting a neurological outcome of a patient post-cardiac arrest. The method includes obtaining, on a processor, first data that indicates values for two or more neurological biomarkers collected from the patient during a first time period following a cardiac arrest. The method also includes obtaining, on the processor, subsequent data that indicates values for the two or more neurological biomarkers collected at a subsequent time period after the first time period following the cardiac arrest. The method also includes determining, on the processor, third data that indicates a prediction of a neurological outcome of the patient during a treatment of the patient based on the first data and the subsequent data. A system is also provided for using a composite score that is formed with the combined use of the values for two or more biomarkers making a prediction of a neurological outcome of a patient post-cardiac arrest.