Patents by Inventor Karl Willmann

Karl Willmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210340257
    Abstract: Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity.
    Type: Application
    Filed: August 22, 2019
    Publication date: November 4, 2021
    Inventors: Lotfi Abou-Elkacem, Juergen Karl Willmann, Benjamin J. Hackel, Lawrence Arthur Stern, Patrick Samuel Lown, Amelie Margarete Marianne Lutz, Rakesh Kumar Bam
  • Publication number: 20210054068
    Abstract: Compositions and methods for detection and diagnosis of pancreatic cancer are disclosed. An engineered anti-thymocyte differentiation antigen 1 (Thy1) single-chain antibody and bioconjugates thereof can be used for detecting and diagnosing pancreatic adenocarcinoma. The anti-Thy1 single-chain antibody selectively binds to the Thy1 antigen, which is overexpressed on pancreatic tumor neovasculature and precancerous lesions, and is capable of detecting pancreatic cancer even at the earliest stages of the disease. Thy1-targeted diagnostic agents can be produced by conjugation of the anti-Thy1 single-chain antibody to various diagnostic agents, such as contrast agents, photoactive agents, or detectable labels that are useful for detection and medical imaging of pancreatic tumors.
    Type: Application
    Filed: June 5, 2017
    Publication date: February 25, 2021
    Inventors: Lotfi Abou-Elkacem, Juergen Karl Willmann
  • Patent number: 10857244
    Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: December 8, 2020
    Assignees: University of Washington Through Its Center for Communication, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Teresa A. Brentnall, Juergen Karl Willmann, Sheng Pan
  • Publication number: 20200254118
    Abstract: Compositions and methods for detection and diagnosis of breast cancer are disclosed. In particular, the invention relates to the use of B7-H3-targeted imaging agents for molecular imaging of breast cancer. Vascular expression of B7-H3 is selectively and significantly higher in breast cancer tissues. Detection of B7-H3 can be used to distinguish between benign and malignant lesions with high diagnostic accuracy. B7-H3-targeted imaging agents can be produced by conjugation of a B7-H3-binding antibody, aptamer, or other ligand to various diagnostic agents, such as contrast agents, photoactive agents, or detectable labels that are useful for detection and medical imaging of breast cancer tumors.
    Type: Application
    Filed: December 2, 2016
    Publication date: August 13, 2020
    Inventors: Sunitha Bachawal, Juergen Karl Willmann
  • Publication number: 20180289844
    Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 11, 2018
    Inventors: Teresa A. Brentnall, Juergen Karl Willmann, Sheng Pan
  • Publication number: 20150079003
    Abstract: The present invention provides reagents and methods for detecting cancer precancerous lesions in a patient.
    Type: Application
    Filed: May 1, 2013
    Publication date: March 19, 2015
    Inventors: Teri Brentnall, Juergen Karl Willmann, Sheng Pang
  • Patent number: 4091779
    Abstract: A method and apparatus for influencing thermo-chemical reactions by means of an electric field, in which the ions formed by the reaction itself are directed by the application of the electric field in order to control the further reaction progress.
    Type: Grant
    Filed: November 28, 1975
    Date of Patent: May 30, 1978
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Helmut Saufferer, Karl Willmann
  • Patent number: 4085717
    Abstract: An atomization system for internal combustion engines for atomizing fuel in an air stream, which includes an atomization space separate from the combustion or working space of the internal combustion engine and traversed at least in part by the combustion air; the electrically conductive fuel supply includes a large number of small capillary tubes projecting into the atomization space from the mounting support thereof while a counter-electrode is provided with a large surface facing the discharge openings of the capillary tubes; additionally, means are provided for guiding the air in such a direction and at such a velocity that the forces exerted on the atomized and electrically charged fuel droplets by the flowing air predominate the electrostatic attracting forces exerted on the droplets by the counter-electrode and thus keep the droplets from the counter-electrode.
    Type: Grant
    Filed: May 7, 1976
    Date of Patent: April 25, 1978
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Karl Willmann, Helmut Saufferer
  • Patent number: 4082070
    Abstract: Apparatus for the conveyance and atomization of a liquid including at least one nozzle directed toward an atomizing chamber, a pressure source or reservoir providing a conveying pressure for the liquid, a fluid-dynamic connection connecting the nozzle and the pressure source or reservoir, and an electrode disposed a predetermined distance in front of the nozzle. At least a portion of the nozzle is formed of an electrically conductive material and is electrically insulated at least with respect to the electrode. A difference in potential is applied between the electrically conductive portion of the nozzle and the electrode during an atomizing period, whereby liquid discharged from the nozzle is atomized.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: April 4, 1978
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Helmut Saufferer, Karl Willmann
  • Patent number: 4077374
    Abstract: An injection valve for internal combustion engines with a valve member forced against its valve seat opposite the injection direction by a spring force and adapted to be lifted off from the valve seat in the injection direction by the hydraulic pressure in the fuel liquid to be injected, and in which the fuel liquid is adapted to be sprayed off in the form of a spray cone; the valve seat is thereby arranged at the end of an electrically conductive tubular spacer member electrically conductively connected with the valve housing and projecting from the valve housing; the outer diameter of the tubular spacer member is thereby considerably smaller than a characteristic valve housing dimension within the area of the connecting place of the spacer member with the valve housing while an annular electrode is arranged at a spacing about the discharge place of the valve which is electrically insulated with respect to the valve housing and the spacer member; the front end edge of the annular electrode, as viewed in the
    Type: Grant
    Filed: April 16, 1976
    Date of Patent: March 7, 1978
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Karl Willmann, Helmut Saufferer
  • Patent number: 4034728
    Abstract: An installation for producing an air/fuel mixture for a mixture-aspirating internal combustion engine, which includes a fuel atomizer equipped with at least one fuel nozzle terminating in the air guide channel and traversed by the sucked-in air; certain surfaces arranged in the flow path of the mixture are thereby at different electric potentials whereby an electrode electrically insulated with respect to the fuel nozzle or nozzles is arranged in front of each of the nozzles with the potential difference applied between the electrode, on the one hand, and the fuel nozzle on the other.
    Type: Grant
    Filed: January 9, 1975
    Date of Patent: July 12, 1977
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Helmut Saufferer, Karl Willmann