Abstract: Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity.

Abstract: Compositions and methods for detection and diagnosis of pancreatic cancer are disclosed. An engineered anti-thymocyte differentiation antigen 1 (Thy1) single-chain antibody and bioconjugates thereof can be used for detecting and diagnosing pancreatic adenocarcinoma. The anti-Thy1 single-chain antibody selectively binds to the Thy1 antigen, which is overexpressed on pancreatic tumor neovasculature and precancerous lesions, and is capable of detecting pancreatic cancer even at the earliest stages of the disease. Thy1-targeted diagnostic agents can be produced by conjugation of the anti-Thy1 single-chain antibody to various diagnostic agents, such as contrast agents, photoactive agents, or detectable labels that are useful for detection and medical imaging of pancreatic tumors.

Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.

Abstract: Compositions and methods for detection and diagnosis of breast cancer are disclosed. In particular, the invention relates to the use of B7-H3-targeted imaging agents for molecular imaging of breast cancer. Vascular expression of B7-H3 is selectively and significantly higher in breast cancer tissues. Detection of B7-H3 can be used to distinguish between benign and malignant lesions with high diagnostic accuracy. B7-H3-targeted imaging agents can be produced by conjugation of a B7-H3-binding antibody, aptamer, or other ligand to various diagnostic agents, such as contrast agents, photoactive agents, or detectable labels that are useful for detection and medical imaging of breast cancer tumors.

Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.

Abstract: The present invention provides reagents and methods for detecting cancer precancerous lesions in a patient.

Abstract: A method and apparatus for influencing thermo-chemical reactions by means of an electric field, in which the ions formed by the reaction itself are directed by the application of the electric field in order to control the further reaction progress.

Abstract: An atomization system for internal combustion engines for atomizing fuel in an air stream, which includes an atomization space separate from the combustion or working space of the internal combustion engine and traversed at least in part by the combustion air; the electrically conductive fuel supply includes a large number of small capillary tubes projecting into the atomization space from the mounting support thereof while a counter-electrode is provided with a large surface facing the discharge openings of the capillary tubes; additionally, means are provided for guiding the air in such a direction and at such a velocity that the forces exerted on the atomized and electrically charged fuel droplets by the flowing air predominate the electrostatic attracting forces exerted on the droplets by the counter-electrode and thus keep the droplets from the counter-electrode.

Abstract: Apparatus for the conveyance and atomization of a liquid including at least one nozzle directed toward an atomizing chamber, a pressure source or reservoir providing a conveying pressure for the liquid, a fluid-dynamic connection connecting the nozzle and the pressure source or reservoir, and an electrode disposed a predetermined distance in front of the nozzle. At least a portion of the nozzle is formed of an electrically conductive material and is electrically insulated at least with respect to the electrode. A difference in potential is applied between the electrically conductive portion of the nozzle and the electrode during an atomizing period, whereby liquid discharged from the nozzle is atomized.

Abstract: An injection valve for internal combustion engines with a valve member forced against its valve seat opposite the injection direction by a spring force and adapted to be lifted off from the valve seat in the injection direction by the hydraulic pressure in the fuel liquid to be injected, and in which the fuel liquid is adapted to be sprayed off in the form of a spray cone; the valve seat is thereby arranged at the end of an electrically conductive tubular spacer member electrically conductively connected with the valve housing and projecting from the valve housing; the outer diameter of the tubular spacer member is thereby considerably smaller than a characteristic valve housing dimension within the area of the connecting place of the spacer member with the valve housing while an annular electrode is arranged at a spacing about the discharge place of the valve which is electrically insulated with respect to the valve housing and the spacer member; the front end edge of the annular electrode, as viewed in the

Abstract: An installation for producing an air/fuel mixture for a mixture-aspirating internal combustion engine, which includes a fuel atomizer equipped with at least one fuel nozzle terminating in the air guide channel and traversed by the sucked-in air; certain surfaces arranged in the flow path of the mixture are thereby at different electric potentials whereby an electrode electrically insulated with respect to the fuel nozzle or nozzles is arranged in front of each of the nozzles with the potential difference applied between the electrode, on the one hand, and the fuel nozzle on the other.