Patents by Inventor Karl X. Chai

Karl X. Chai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of prostasin
    Patent number: 7666981
    Abstract: A class of proteins useful as inhibitors of prostasin and method for identifying them are provided. These proteins have the structure wherein the amino acids P1-P4 from the scissile bond are respectively leu-ile-ala-arg and the amino acids at positions P5-P15 are serpin sequences.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: February 23, 2010
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Karl X. Chai, Li-Mei Chen
  • Method of identifying and treating invasive carcinomas
    Patent number: 6864093
    Abstract: Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: March 8, 2005
    Assignee: University of Central Florida
    Inventors: Karl X. Chai, Li-Mei Chen, Lee Chao, Julie Chao
  • Method of identifying and treating invasive carcinomas
    Patent number: 6706483
    Abstract: Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line. MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: March 16, 2004
    Assignee: University of Central Florida
    Inventors: Karl X. Chai, Li-Mei Chen, Lee Chao, Julie Chao
  • Method of identifying and treating invasive carcinomas
    Patent number: 6689614
    Abstract: Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: February 10, 2004
    Assignee: University of Central Florida
    Inventors: Karl X. Chai, Li-Mei Chen, Lee Chao, Julie Chao
  • Synthetic substrates for prostasin
    Publication number: 20040018580
    Abstract: Synthetic peptide substrates of prostasin, a method for synthesizing them and a prostasin assay are provided.
    Type: Application
    Filed: May 8, 2003
    Publication date: January 29, 2004
    Inventors: Karl X. Chai, Li-Mei Chen
  • Method of identifying and treating invasive carcinomas
    Patent number: 6569684
    Abstract: Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: May 27, 2003
    Assignee: University of Central Florida
    Inventors: Karl X. Chai, Li-Mei Chen, Lee Chao, Julie Chao
  • Method of identifying and treating invasive carcinomas
    Publication number: 20020039753
    Abstract: Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU- 145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein.
    Type: Application
    Filed: January 5, 2001
    Publication date: April 4, 2002
    Inventors: Karl X. Chai, Li-Mei Chen, Lee Chao, Julie Chao