Patents by Inventor Karl Yoder

Karl Yoder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190118173
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: August 31, 2018
    Publication date: April 25, 2019
    Inventors: Tanya S. KANIGAN, Steve SMITH, John LINTON, Robert HESS, Karl YODER, Colin J. H. BRENAN
  • Patent number: 10213761
    Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: February 26, 2019
    Assignee: Life Technologies Corporation
    Inventors: Colin J. H. Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya S. Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder
  • Patent number: 10065189
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 4, 2018
    Assignee: Life Technologies Corporation
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin John Herbert Brenan
  • Patent number: 9428800
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: August 30, 2016
    Assignee: Life Technologies Corporation
    Inventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Madrone, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Publication number: 20160167044
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: February 22, 2016
    Publication date: June 16, 2016
    Inventors: Tanya S. KANIGAN, Steve SMITH, John LINTON, Robert HESS, Karl YODER, Colin John Herbert BRENAN
  • Patent number: 9266108
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: February 23, 2016
    Assignee: Life Technologies Corporation
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin John Herbert Brenan
  • Publication number: 20150011436
    Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.
    Type: Application
    Filed: June 9, 2014
    Publication date: January 8, 2015
    Inventors: Colin J. H. Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya S. Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder
  • Publication number: 20140179566
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Application
    Filed: March 3, 2014
    Publication date: June 26, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: John LINTON, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Patent number: 8697452
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 15, 2014
    Assignee: Life Technologies Corporation
    Inventors: John Linton, Arrin Katz, Colin Brenan, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya Kanigan, Kristine Friesen, Thomas Morrison, Javier Garcia
  • Publication number: 20140031262
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Patent number: 8545772
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: October 1, 2013
    Assignee: Life Technologies Corporation
    Inventors: Tanya Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Publication number: 20120245038
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 27, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20120164748
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: December 23, 2011
    Publication date: June 28, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Patent number: 8105554
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 31, 2012
    Assignee: Life Technologies Corporation
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Publication number: 20110003699
    Abstract: A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume, the array including a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. A thermal cycler having at least one thermally controlled surface is adapted to thermally contact the case.
    Type: Application
    Filed: December 18, 2009
    Publication date: January 6, 2011
    Applicant: BioTrove, Inc.
    Inventors: Karl Yoder, Colin Brenan, John Linton, Leila Hasan, Robert Ellis, Arrin Katz, Tom Morrison, Jorge Fonseca
  • Patent number: 7682565
    Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: March 23, 2010
    Assignee: BioTrove, Inc.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20090062134
    Abstract: A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
    Type: Application
    Filed: October 3, 2008
    Publication date: March 5, 2009
    Applicant: BIOTROVE, INC.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20090062152
    Abstract: A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
    Type: Application
    Filed: October 1, 2008
    Publication date: March 5, 2009
    Applicant: BIOTROVE, INC.
    Inventors: John Linton, Karl Yoder, Robert Hess, Leila Hasan, Robert Ellis, Tanya S. Kanigan, Kristine Friesen, Arrin Katz, Colin Brenan, Tom Morrison, Javier Garcia
  • Publication number: 20070003448
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: March 11, 2005
    Publication date: January 4, 2007
    Inventors: Tanya Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Publication number: 20060105453
    Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.
    Type: Application
    Filed: August 4, 2005
    Publication date: May 18, 2006
    Inventors: Colin Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder