Patents by Inventor Karl Zilles

Karl Zilles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8160317
    Abstract: The invention relates to a method for the topographical presentation of structural alterations in an examined brain using volume data records. In line with the invention, this method is distinguished in that functional areas are mapped by extracting profiles, where the profiles record boundaries for two functional areas in the examined brain, in that the boundaries of the two functional areas are recorded by calculating a multivariant distance measurement, and in that a microstructure in the region of the boundaries of the two cortical areas is recorded and is compared with at least one microstructure in a boundary region of a reference brain. To increase the comparability of various areas in various brains taking into account the interindividual variability, it is expedient for the volume data records to be transformed to a target volume data record using an elastic registration method.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: April 17, 2012
    Assignee: Forschungszentrum Juelich GmbH
    Inventors: Katrin Amunts, Karl Zilles, Hartmut Mohlberg, Axel Schleicher, Lars Hömke
  • Publication number: 20080298653
    Abstract: The invention relates to a method for the topographical presentation of structural alterations in an examined brain using volume data records. In line with the invention, this method is distinguished in that functional areas are mapped by extracting profiles, where the profiles record boundaries for two functional areas in the examined brain, in that the boundaries of the two functional areas are recorded by calculating a multivariant distance measurement, and in that a microstructure in the region of the boundaries of the two cortical areas is recorded and is compared with at least one microstructure in a boundary region of a reference brain. To increase the comparability of various areas in various brains taking into account the interindividual variability, it is expedient for the volume data records to be transformed to a target volume data record using an elastic registration method.
    Type: Application
    Filed: November 29, 2006
    Publication date: December 4, 2008
    Applicant: Forschungszentrum Julich GMBH
    Inventors: Katrin Amunts, Karl Zilles, Hartmut Mohlberg, Axel Schleicher, Lars Homke
  • Patent number: 6891372
    Abstract: The invention relates to an imaging method. Layer or volume areas are selected by radiating high-frequency pulses and applying at least one magnetic potential field. Nuclear magnetic resonances are excited and are detected as measuring signals in said areas. According to the invention, the method is carried out in such a way that different layer or volume areas are successively selected and the corresponding measuring signals are detected by means of the magnetic potential field and that layer or volume images of the individual layer or volume areas are produced after the measuring signals for the different layer or volume areas have been detected.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: May 10, 2005
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Sven Steinhoff, Nadim Joni Shah, Karl Zilles
  • Patent number: 6781372
    Abstract: The present invention relates to a process for examining an object, whereby properties of the object are detected at different times within a spatial frequency space formed by spatial frequencies. The process is carried out in such a way that consecutive images are recorded in overlapping areas of the spatial frequency space and, additionally, in areas of the spatial frequency space that differ from each other.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 24, 2004
    Assignee: Forschungszentrum Jülich GmbH
    Inventors: Nadim Joni Shah, Karl Zilles
  • Patent number: 6707299
    Abstract: The invention relates to an imaging method for examining substances which contain atoms with an indirect nuclear spin-nuclear spin interaction. At least one excitation impulse produces a precession of at least several nuclear spins with an additional phase angle &Dgr;&phgr;=−&ggr;r&Dgr;Bz&tgr; in relation to an already existing precession in an outer magnetic field so that a transversal magnetization spreads out perpendicularly in relation to the outer magnetic field whereby effecting a relaxation of the transversal magnetization with relaxation times T2. The inventive method is characterized in that at least one rephasing pulse, which rephases the transversal magnetiztion, is applied after the excitation pulse and after a recording of at least one highly resolved image, and in that additional images are subsequently recorded with a lower resolution.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: March 16, 2004
    Assignee: Forschungszentrum Jülich GmbH
    Inventors: Nadim Joni Shah, Karl Zilles
  • Patent number: 6666047
    Abstract: The invention relates to a polarizer for noble gases comprising a glass sample cell and a pressure chanter in which the sample cell is located. High pressure and accompanying broadband or narrow-band lasers can be similarly provided in an optimal manner. To this end, the polarizer is operated at pressures of 30 bar and higher.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: December 23, 2003
    Assignee: Forschungszentrum Julich GmbH
    Inventors: Nadim Joni Shah, Stephan Appelt, Timur Unlu, Horst Halling, Karl Zilles
  • Publication number: 20030076098
    Abstract: The invention relates to an imaging method. Layer or volume areas are selected by radiating high-frequency pulses and applying at least one magnetic potential field. Nuclear magnetic resonances are excited and are detected as measuring signals in said areas. According to the invention, the method is carried out in such a way that different layer or volume areas are successively selected and the corresponding measuring signals are detected by means of the magnetic potential field and that layer or volume images of the individual layer or volume areas are produced after the measuring signals for the different layer or volume areas have been detected.
    Type: Application
    Filed: August 19, 2002
    Publication date: April 24, 2003
    Inventors: Sven Steinhoff, Nadim Joni Shah, Karl Zilles
  • Publication number: 20030057945
    Abstract: The invention relates to a method for analysing a sample. According to said method, the sample is irradiated by at least one excitation pulse and several rephasing pulses, in such a way that echo signals are generated and determined. The inventive method is characterised in that all echo signals are encoded with a substantially identical phase position and that the exposure sequence is then repeated at least once.
    Type: Application
    Filed: August 19, 2002
    Publication date: March 27, 2003
    Inventors: Nadim Joni Shah, Karl Zilles
  • Publication number: 20030057946
    Abstract: The invention relates to an imaging method for examining substances, wherein a precession of at least one nuclear spin having an additional phase angle &Dgr;&phgr;=−&ggr;r&Dgr;Bz&tgr; relative to an already existing precession is generated by indirect nuclear spin-nuclear spin interaction in an external magnetic field with the purpose of spreading perpendicular magnetization vertical to the magnetic field so that relaxation of perpendicular magnetization occurs within a relaxation time T2*. According to the invention, the method is characterized in that the relaxation is recorded in the form of at least one high resolution image directly after the excitation pulse using echo-planar-imaging and in that more images are recorded at lower resolution thereafter.
    Type: Application
    Filed: August 19, 2002
    Publication date: March 27, 2003
    Inventors: Nadim Joni Shah, Maxim Zaitsev, Karl Zilles
  • Publication number: 20030042904
    Abstract: The invention relates to an imaging method. Layer or volume areas are selected by radiating high-frequency pulses and applying a magnetic gradient field which is optionally composed of several individual components. Nuclear magnetic resonances are excited and detected as measured signals in said areas. According to the inventive method, the measured signals are detected in a first acquisition sequence for different echo times. Essentially similar phase positions are selected for different echo times in the acquisition sequence and the acquisition sequence is repeated at least once. The invention also relates to a device for processing image data. Said device comprises at least one memory for storing detected measured data in a kx-dimension, a t-dimension and a ky-dimension. The inventive device is characterised in that said device contains a sorter which rearranges the raw data into a sequence, wherein the data of the ky-dimension is arranged upstream in relation to the t-dimension.
    Type: Application
    Filed: August 26, 2002
    Publication date: March 6, 2003
    Inventors: Stefan Wiese, Nadim Joni Shah, Karl Zilles
  • Publication number: 20010024120
    Abstract: The invention relates to a process to examine at least one object, whereby properties of the object are detected at different times within a spatial-frequency space formed by spacial-frequencies.
    Type: Application
    Filed: December 21, 2000
    Publication date: September 27, 2001
    Inventors: Nadim Joni Shah, Karl Zilles