Patents by Inventor Karla A. Kirkegaard

Karla A. Kirkegaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATION BY CONTROLLING INTERFERON-GAMMA LEVELS WITH THE LONG NON-CODING RNA NeST
    Publication number: 20140056929
    Abstract: Compositions and methods of modulating an immune response by controlling levels of interferon-gamma (IFN-?) production by leukocytes are disclosed. Adjustment of IFN-? levels is achieved by increasing or decreasing the activity of NeST (nettoie Salmonella pas Theiler's [cleanup Salmonella not Theiler's]), a long non-coding RNA that induces expression of IFN-?. In particular, the invention relates to the use of NeST and inhibitors of NeST to modulate levels of IFN-? for treatment of inflammatory conditions, autoimmune diseases, infectious diseases, immunodeficiency, and cancer.
    Type: Application
    Filed: August 23, 2013
    Publication date: February 27, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karla A. Kirkegaard, Michel Brahic, J. Antonio Gomez, Howard Yuan-Hao Chang
  • Methods of identifying anti-viral agents
    Patent number: 7476499
    Abstract: The present invention provides methods of identifying candidate anti-viral agents.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: January 13, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karla A. Kirkegaard, Scott M. Crowder
  • METHODS OF IDENTIFYING ANTI-VIRAL AGENTS
    Publication number: 20080090225
    Abstract: The present invention provides methods of identifying candidate anti-viral agents.
    Type: Application
    Filed: June 13, 2007
    Publication date: April 17, 2008
    Inventors: Karla Kirkegaard, Scott Crowder
  • Viral vectors useful in induction of humoral or cellular immunity
    Patent number: 7247619
    Abstract: The invention features recombinant viral vectors that take advantage of the activity of picornaviral protein 3A in modulating cytokine secretion and antigen presentation on MHC Class I (MHC I), which in turn provides for modulation of a Th1-mediated immune response to the transfected host cell. Specifically, a recombinant viral vector comprising a sequence encoding picornaviral protein 3A provides for decreased antigen presentation on MHC I and a decreased incidence of Th1-mediated immune response, while a recombinant picornaviral vector that is deficient in protein 3A production provides for increased cytokine secretion, increased antigen presentation on MHC I and increased Th1-mediated immune response towards the transfected host cell. The invention also features methods of inducing humoral or cellular immunity using the vectors.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: July 24, 2007
    Inventors: Karla Kirkegaard, Dana A. Dodd, Stephen B. Deitz, John Doedens
  • Viral vectors useful in induction of humoral or cellular immunity
    Publication number: 20040052765
    Abstract: The invention features recombinant viral vectors that take advantage of the activity of picornaviral protein 3A in modulating cytokine secretion and antigen presentation on MHC Class (MHC I), which in turn provides for modulation of a Th1-mediated immune response to the transfected host cell. Specifically, a recombinant viral vector comprising a sequence encoding picornaviral protein 3A provides for decreased antigen presentation on MHC 1 and a decreased incidence of Th1-mediated immune response, while a recombinant picornaviral vector that is deficient in protein 3A production provides for increased cytokine secretion, increased antigen presentation on MHC and increased Th1-mediated immune response towards the transfected host cell. The invention also features methods of inducing humoral or cellular immunity using the vectors.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 18, 2004
    Inventors: Karla Kirkegaard, Dana A. Dodd, Stephen B. Deitz, John Doedens
  • Inhibitors of viral infection
    Publication number: 20020164348
    Abstract: The present invention provides a viral RNA-dependent RNA polymerase pharmacophore which is characterized by binding to a conserved interface binding surfaces of a viral RNA-dependent RNA polymerase.
    Type: Application
    Filed: May 22, 2001
    Publication date: November 7, 2002
    Inventors: Karla Kirkegaard, Kathy Richmond, John Lyle, Steve Schultz, Scott Hobson