Patents by Inventor Karl-Heinz Budt

Karl-Heinz Budt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrug derivatives of enzyme inhibitors having hydroxyl groups, a process for preparing them, and their use
    Patent number: 5804559
    Abstract: The invention concerns prodrugs of enzyme inhibitors in which at least one OH-- group in the enzyme inhibitor has been converted into a derivative grouping of the formula III, IV or V: ##STR1## in which the groups R.sup.11 to R.sup.25 and s,l, m, o, q, and r are as defined in the description. Such prodrugs exhibit an improved solubility in water and improved pharmaco-kinetic characteristics.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: September 8, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Budt, Bernd Stowasser, Anuschirwan Peyman, Jochen Knolle, Irvin Winkler, Hans Gerd Berscheid
  • Inhibitors of retroviral proteases
    Patent number: 5712417
    Abstract: The present invention relates to compounds of the formula I ##STR1## wherein A, Y, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: January 27, 1998
    Assignee: Abbott Laboratories
    Inventors: Karl-Heinz Budt, Bernd Stowasser, Dieter Ruppert, Christoph Meichsner, Arnold Paessens, Jutta Hansen, Jochen Knolle
  • Phosphinic acid derivatives, their preparation and their use
    Patent number: 5707979
    Abstract: Compounds of the formula I, ##STR1## in which the symbols or substituents A, B, D, D*, E and E* have the meanings given in the specification, inhibit aspartyl proteases and are suitable for controlling viral diseases.
    Type: Grant
    Filed: June 28, 1995
    Date of Patent: January 13, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, Wilhelm Stahl, Karl-Heinz Budt, Dieter Ruppert, Henning Schussler, Konrad Wagner
  • Inhibitors of retroviral proteases
    Patent number: 5663139
    Abstract: The present invention relates to a compound of the formula ##STR1## in which A, Q, R.sup.2, R.sup.3 and R.sup.4, and also the corresponding, asterisked radicals, are defined as indicated in the description, to a process for their preparation, and also to their use for inhibiting retroviral proteases.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: September 2, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bernd Stowasser, Jian-Qi Li, Anuschirwan Peyman, Karl-Heinz Budt
  • Inhibitors of retroviral proteases
    Patent number: 5629431
    Abstract: The present invention relates to compounds of the formula I ##STR1## in which A, Q, R.sup.2, R.sup.3, R.sup.4 and the corresponding radicals with an * are defined as indicated in the description, a process for the preparation thereof, and the use thereof for inhibiting retroviral proteases.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 13, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Budt, Anuschirwan Peyman
  • Bis(aminomethyl)phosphinic acid derivatives and process for the preparation of bis(aminomethyl)phosphinic acid derivatives
    Patent number: 5608098
    Abstract: Novel bis(aminomethyl)phosphinic acid derivatives and process for the preparation of bis(aminomethyl)phosphinic acid derivativesCompounds of the formula VI ##STR1## can be prepared by reaction of a compound of the formula IV ##STR2## with a base to give a compound of the formula Va or Vb ##STR3## and subsequent reaction with carbon nucleophiles; alternatively the compound of the formula VI is prepared by direct reaction of the compound of the formula IV e.g. with R.sup.2 Cu(CN)Li.sub.2, the above substituents having the meanings mentioned.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: March 4, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, J org Spanig, Karl-Heinz Budt
  • Process for the preparation of derivatives of bis(amino-methyl) phosphinic acid
    Patent number: 5510504
    Abstract: A process for the preparation of .alpha.- or .alpha.,.alpha.'-substituted derivatives of the bis(aminomethyl)phosphinic acid of the formula I and their acid or basic salts, ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are defined as in the description, wherein a bis(aminomethyl)phosphinate is converted into the corresponding bisimine, which is alkylated by R.sup.2 and R.sup.3 in the .alpha.- and/or .alpha.,.alpha.'-position after reaction with a base, and is converted into a compound of the formula I by subsequent treatment with an acid.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: April 23, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, Karl-Heinz Budt, Jorg Spanig, Jian-Qi Li, Bernd Stowasser
  • Process for the preparation of penem compounds
    Patent number: 5198544
    Abstract: Compound I ##STR1## is obtained by reaction of compound II with compound III
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: March 30, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Budt, Walter Durokheimer, Gerd Fischer, Rolf Horlein, Reiner Kirrstetter, Rudolf Lattrell