Patents by Inventor Karlheinz Drauz

Karlheinz Drauz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of 2,5 -diketopiperazines,2,5-diketopiperazines , dipeptides and their use thereof
    Publication number: 20040024180
    Abstract: Process for the production of 2,5-diketopiperazines of general formula I, 1
    Type: Application
    Filed: May 28, 2003
    Publication date: February 5, 2004
    Inventors: Karlheinz Drauz, Gunter Knaup
  • Resolution of DL-racemic mixtures
    Patent number: 6673942
    Abstract: The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: January 6, 2004
    Assignees: Degussa AG, Yeda Research and Development Co., Ltd.
    Inventors: Matthias Kottenhahn, Guenter Knaup, Karlheinz Drauz, Meir Lahav, David Zbaida
  • N-arylsulfonamide and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives
    Patent number: 6664400
    Abstract: The present invention relates to a compound of Formula 3 wherein X is H, F or Cl; Y is F or Cl; R1 is C1-C3 haloalkyl, C2-C4 alkoxyalkyl; C2-C6 haloalkoxyalkyl or C2-C6 cyanoalkyl; R2 is H, C1-C4 alkyl, C1-C4 haloalkyl, C3-C4 alkenyl, C3-C4 alkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl; R3 is H or OH; and R4 is H, F or Cl; provided that when R3 is H then R4 is F or Cl and when R3 is OH then R4 is H.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: December 16, 2003
    Assignee: Degussa AG
    Inventors: Eric Deguyon Taylor, Viacheslav Alexandrovich Petrov, Matthias Schaeffer, Karlheinz Drauz, Anne Vogt, Christoph Weckbecker, Steven H. Swearingen, Balreddy Kamireddy
  • Chromatographic separation of enantiomers of bicyclic lactams
    Patent number: 6656902
    Abstract: A method for separation of enantiomers of a lactam represented by formula (I): where n and m are each, independently, 0, 1, 2, or 3; P is H or an N-protecting group; and the dotted line represents an optional double bond, by liquid chromatographing the mixture on a chiral stationary phase, where said stationary phase is derivitized with at least one sugar derivative, with an eluent which comprises acetonitrile.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: December 2, 2003
    Assignee: Degussa AG
    Inventors: Kurt Guenther, Stefan Merget, Karlheinz Drauz, Hans-Peter Krimmer
  • Process for the production of amino acids using racemase and acylase
    Patent number: 6656710
    Abstract: The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: December 2, 2003
    Assignee: Degussa AG
    Inventors: Andreas Bommarius, Karlheinz Drauz, Stefan Verseck
  • Amidase from variovorax
    Publication number: 20030186423
    Abstract: The present invention relates to an amidase enzyme, nucleic acids encoding the amidase, as well as methods of employing the nucleic acids and/or amidase to produce, for example, enantiomericallyenriched compounds such as D-amino acids.
    Type: Application
    Filed: December 4, 2002
    Publication date: October 2, 2003
    Applicant: Degussa AG
    Inventors: Stefan Verseck, Karlheinz Drauz, Andreas Bommarius, Maria-Regina Kula, Lutz Krieg, Heike Slusarczyk, Marion Ansorge-Schumacher
  • Polymeric diphosphine ligands for homogeneously soluble hydrogenation catalysts, process for the production thereof and use
    Patent number: 6624248
    Abstract: Molecular weight-enlarged, homogeneously soluble ligands are provided that are especially useful for hydrogenation catalysts, wherein the ligands contain homochiral active centers of bis(3,4-diarylphosphinyl)pyrrolidines, and their use in producing cataylsts for enantioselective reactions, as well as the catalysts thus produced.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: September 23, 2003
    Assignee: Degussa AG
    Inventors: Olaf Burkhardt, Jens Woltinger, Andreas Bommarius, Juan Jose Almena Perea, Hans Henniges, Karlheinz Drauz, Andreas Karau, Jean-Louis Philippe, Hans-Peter Krimmer, Gunther Oehme
  • Molecular weight-enlarged ligands for asymmetric, homogeneously soluble hydrogenation catalysts, process for the production thereof and use
    Patent number: 6617480
    Abstract: The present invention relates to a molecular weight-enlarged, homogeneously soluble ligand, which includes: an average molecular weight of at least 1000 g/mol; a molecular weight-enlarging polymer; optionally, a linker; and at least one homochiral active center; wherein the active center is bound to the molecular weight-enlarging polymer through the linker or is bound directly to the molecular weight-enlarging polymer, methods of preparing, catalysts containing same, and methods of using same.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: September 9, 2003
    Assignee: Degussa AG
    Inventors: Hans-Peter Krimmer, Jens Woeltinger, Olaf Burkhardt, Ingo Klement, Hans Henniges, Karlheinz Drauz, Andreas Bommarius, Jean-Louis Philippe, Andreas Karau
  • Activated rec-D-hydantoinases
    Publication number: 20030143677
    Abstract: Rec-hydantoinases which may be obtained in more active form by a the process described herein. The invention also relates, inter alia, to a rechydantoinase from the organism Arthrobacter crystallopoietes DSM20117, to nucleic acids which code for such a protein and to vectors containing said nucleic acids and to uses thereof.
    Type: Application
    Filed: June 24, 2002
    Publication date: July 31, 2003
    Applicant: DEGUSA AG
    Inventors: Oliver May, Andreas Bommarius, Karlheinz Drauz, Martin Siemann-Herzberg, Christoph Syldatk, Markus Werner, Josef Altenbuchner
  • Arthrobacter D-carbamoylase and methods of preparing enantiomerically enriched D-amino acids
    Publication number: 20030143244
    Abstract: The present invention relates to a new D-carbamoylase and the gene sequences which code for this from the organism Arthrobacter crystallopoietes DSM 20117. Plasmids, vectors, microorganisms, particular primers and specific possible uses of the enzymes according to the invention are also mentioned. The invention moreover describes a new process for the discovery of enzymes which can be employed in a process for the preparation of D-amino acids starting from 5′-substituted hydantoins.
    Type: Application
    Filed: March 26, 2002
    Publication date: July 31, 2003
    Applicant: Degussa AG
    Inventors: Karlheinz Drauz, Oliver May, Andreas Bommarius, Christoph Syldatk, Josef Altenbuchner, Markus Werner, Martin Siemann-Herzberg
  • Method of producing amino carboxylic acids
    Publication number: 20030120084
    Abstract: The present invention is directed to a method for producing amino acids by reacting halogenated carboxylic acid ester (haloacid esters) with a metal cyanate in the presence of an alcohol and by subsequent acidic saponification of the urethane carbonic acid formed. The method is characterized by the metal cyanate being placed at an elevated temperature in an organic solvent and the other reactants being continuously charged into the mixture over a defined time period.
    Type: Application
    Filed: November 25, 2002
    Publication date: June 26, 2003
    Applicant: Degussa AG
    Inventors: Oliver Meyer, Thomas Kalz, Karlheinz Drauz
  • Poly-&bgr;-amino acids, preparation and use
    Patent number: 6559283
    Abstract: Poly-&bgr;-amino acids and their use in catalytic organic reactions, especially in epoxidation procedures, are provided.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: May 6, 2003
    Assignee: Degussa AG
    Inventors: Karlheinz Drauz, Olaf Burkhardt, Stan M. Roberts, John Skidmore, Paul Coffey
  • Catalysts for the enantioselective epoxidation of C═C double bonds
    Patent number: 6538105
    Abstract: Compositions are disclosed which comprise a homopolyamino acid and stereoisomers thereof adsorbed on an insoluble support material. The compositions are useful as catalysts for the stereoselective epoxidation of olefins.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: March 25, 2003
    Assignee: Degussa AG
    Inventors: Karlheinz Drauz, Stan M. Roberts, Thomas Geller, Anupma Dhanda
  • Hydantoinase variants with improved properties and their use for the production of amino acids
    Patent number: 6524837
    Abstract: Hydantoinase enzymes which are mutants of a previously isolated hydantoinase having the amino acid SEQ. ID. NO. 2. The mutants include amino acid substitutions at positions 95, 154, 180, 251 and/or 255 of the wild type hydantoinase (SEQ. ID. NO. 2). The mutant hydantoinases, like the parent hydantoinase, are used in the production of optically pure amino acids.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: February 25, 2003
    Assignee: California Institute of Technology
    Inventors: Frances H. Arnold, Oliver May, Karlheinz Drauz, Andreas Bommarius
  • Process for synthesis of enantiomerically enriched &bgr;-amino acids
    Patent number: 6492544
    Abstract: Enantiomerically enriched N-acylated &bgr;-amino acids are synthesized by catalytic enantioselective hydrogenation of E-isomers and Z-isomers of 3-amino acrylic acid derivatives in the presence of a catalysts of formula (I)
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: December 10, 2002
    Assignee: Degussa AG
    Inventors: Hans-Peter Krimmer, Karlheinz Drauz, Jutta Lang, Armin Boerner, Detlef Heller, Jens Holz
  • Process for the preparation of 3-amino-2-oxo-pyrrolidines, novel intermediates and their use
    Patent number: 6492541
    Abstract: The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II which can be prepared from the intermediate compounds V.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: December 10, 2002
    Assignee: Degussa-Huls Aktiengesellschaft
    Inventors: Karlheinz Drauz, Günter Knaup, Michael Schwarm
  • Process for the production of organic compounds in a membrane reactor
    Patent number: 6472571
    Abstract: Process for the production of organic compounds in a membrane reactor. Inorganic membranes composed of an inorganic backing layer and an inorganic interlayer are used in the membrane reactor. The inorganic interlayer may be modified with organic groups.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: October 29, 2002
    Assignee: Degussa-Huls AG
    Inventors: Andreas Karau, Jens Wöltinger, Olaf Burkhardt, Andreas Bommarius, Kai Boldt, Jean-Louis Philippe, Hans Henniges, Karlheinz Drauz
  • Amino acid composition for hemodialysis
    Publication number: 20020144946
    Abstract: An amino acid composition suitable for hemodialysis and a dialysis solution that can be prepared from the amino acid mixture. When the inventive amino acid composition is used for this purpose, the “shrinking men” phenomenon can be prevented. Also provides are a hemodialysis process and apparatus.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 10, 2002
    Inventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
  • N-arylsulfonamide and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives
    Publication number: 20020137946
    Abstract: This invention is directed to compounds and intermediates of Formulae (6 and 3), useful in preparing herbicidal sulfonamides of Formula (1), including all geometric and stereoisomers thereof, and agricultural salts thereof, wherein X is H, F or Cl; Y is F or Cl; R1 is C1-C3 haloalkyl, C2-C4 alkoxyalkyl; C2-C6 haloalkoxyalkyl or C2-C6 cyanoalkyl; R2 is H, C1-C4 alkyl, C1-C4 haloalkyl; C3-C4 alkenyl, C3-C4 alkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl; R3 is H or OH; R4 is H, F or Cl; and R5 is F or Cl; provided that when R3 is H then R4 is F or Cl and when R3 is OH then R4 is H.
    Type: Application
    Filed: January 4, 2002
    Publication date: September 26, 2002
    Applicant: DEGUSSA AG
    Inventors: Eric Deguyon Taylor, Viacheslav Alexandrovich Petrov, Matthias Schaeffer, Karlheinz Drauz, Anne Vogt, Christoph Weckbecker, Steven H. Swearingen, Balreddy Kamireddy
  • 1-[N2-((S)-ethoxycarbonyl)-3-phenylproply)-N6-trifluoroacetyl]-L-ysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
    Patent number: 6455705
    Abstract: A method of isolating 1-[N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE). The solvent or solvent mixture used for the extraction is also a main constituent of the solvent or solvent mixture from which the crystallization takes place. High yield as well as good purity of the end product are obtained, without distillation. 1-[N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE) is described as a precursor for producing an ACE inhibitor.
    Type: Grant
    Filed: December 24, 1998
    Date of Patent: September 24, 2002
    Assignee: Degussa Aktiengesellschaft
    Inventors: Matthias Kottenhahn, Roland Möller, Michael Kraft, Karlheinz Drauz, Klaus Stingl